ID   E2ZK04_9FIRM            Unreviewed;       287 AA.
AC   E2ZK04;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:EFQ06487.1};
DE            EC=1.3.1.12 {ECO:0000313|EMBL:EFQ06487.1};
GN   ORFNames=HMPREF9436_02006 {ECO:0000313|EMBL:EFQ06487.1};
OS   Faecalibacterium cf. prausnitzii KLE1255.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Faecalibacterium.
OX   NCBI_TaxID=748224 {ECO:0000313|EMBL:EFQ06487.1, ECO:0000313|Proteomes:UP000006028};
RN   [1] {ECO:0000313|EMBL:EFQ06487.1, ECO:0000313|Proteomes:UP000006028}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KLE1255 {ECO:0000313|EMBL:EFQ06487.1,
RC   ECO:0000313|Proteomes:UP000006028};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA   Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA   Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA   Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA   Chinwalla A., Mardis E.R., Wilson R.K.;
RL   Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFQ06487.1}.
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DR   EMBL; AECU01000165; EFQ06487.1; -; Genomic_DNA.
DR   RefSeq; WP_005943522.1; NZ_GL538340.1.
DR   AlphaFoldDB; E2ZK04; -.
DR   STRING; 748224.HMPREF9436_02006; -.
DR   eggNOG; COG0287; Bacteria.
DR   HOGENOM; CLU_055968_2_0_9; -.
DR   OrthoDB; 9802008at2; -.
DR   BioCyc; FCF748224-HMP:GTSS-1112-MONOMER; -.
DR   Proteomes; UP000006028; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR046825; PDH_C.
DR   InterPro; IPR046826; PDH_N.
DR   InterPro; IPR003099; Prephen_DH.
DR   PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF20463; PDH_C; 1.
DR   Pfam; PF02153; PDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:EFQ06487.1}.
FT   DOMAIN          6..287
FT                   /note="Prephenate/arogenate dehydrogenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51176"
SQ   SEQUENCE   287 AA;  32051 MW;  AB60ED3A01772343 CRC64;
     MLDKTKRYLV VGLGLLGGKY ALELTKAGFH VDGINRSEGH LQYALEHGYI ASGKTHDFED
     LVSSADHIIF GLYPTALIEW FRTYGHLLKP GCIFTDVSGV KTGLVEPVQA MCPAGVEFIA
     SHPMAGRETS SVEHAAEVNF APANFIITPT EKNTPEAIQW AKDLAEVLGF HHICTLTVQE
     HDKMIGYVSQ LCHAIAVSLM CANDNSSLCE YTGDSFRDLT RIARINDKMW AELFLWNKEN
     LISEIDQFDA ALQEMRAALV ADDRDKLEQM FRLSTQRRAA FDKKLPE
//