ID E3C8E8_9LACO Unreviewed; 430 AA.
AC E3C8E8;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Putative Na+/H+ antiporter NhaC {ECO:0000313|EMBL:EFQ52996.1};
GN ORFNames=HMPREF9265_2104 {ECO:0000313|EMBL:EFQ52996.1};
OS Limosilactobacillus oris PB013-T2-3.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Limosilactobacillus.
OX NCBI_TaxID=908339 {ECO:0000313|EMBL:EFQ52996.1, ECO:0000313|Proteomes:UP000003070};
RN [1] {ECO:0000313|EMBL:EFQ52996.1, ECO:0000313|Proteomes:UP000003070}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB013-T2-3 {ECO:0000313|EMBL:EFQ52996.1,
RC ECO:0000313|Proteomes:UP000003070};
RA Durkin A.S., Madupu R., Torralba M., Gillis M., Methe B., Sutton G.,
RA Nelson K.E.;
RL Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NhaC Na(+)/H(+) (TC 2.A.35) antiporter
CC family. {ECO:0000256|ARBA:ARBA00038435}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFQ52996.1}.
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DR EMBL; AEKL01000056; EFQ52996.1; -; Genomic_DNA.
DR AlphaFoldDB; E3C8E8; -.
DR eggNOG; COG1757; Bacteria.
DR Proteomes; UP000003070; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR PANTHER; PTHR33451; MALATE-2H(+)/NA(+)-LACTATE ANTIPORTER; 1.
DR PANTHER; PTHR33451:SF6; NA(+)_H(+) ANTIPORTER NHAC; 1.
DR Pfam; PF03553; Na_H_antiporter; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 20..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 44..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 82..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 174..430
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
SQ SEQUENCE 430 AA; 45316 MW; D25D677C8AE88515 CRC64;
MPIFKKSSQD AEPSFGFSES LAVLIVILCI LGYLIIFKQQ EPQAPLFIAF ILLAVYGKLR
GFKWDTVMEG MRSGLRAGVD PLVIFLSIGV LIATWIFSGT IPTIMYFGFK IISVQFFLPT
VFIVCTLVGV ACGSSFTTVS TMGIAFIGIG ATLKINPGLT AGVIVSGAFC GSNISPLSGT
TNLAASVGQI SIYEHIRSLL ITDIPAWAIC VVLYTVLGLN SKQVSLNAVH QMMNGLADGF
WISGWALLPV ALLIILAILQ VPAIPSLGLG SLFAAALGWI HAPSTSITAI TKTIMMGYVS
HTGNKPIDAL LSKGGISSML TSLALIVFAL ALGGLLIKFN IINAIIDHLS GIVKTAGRLT
LATAITCIGV NLMVGEHYLA IILPGQSFLP AFDKLGLKRK YLTRILNDAG AAVNAIVPWS
VSGVFIAGAL
//
