ID E3CUP5_9BACT Unreviewed; 507 AA.
AC E3CUP5;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=Apau_0697 {ECO:0000313|EMBL:EFQ23125.1};
OS Aminomonas paucivorans DSM 12260.
OC Bacteria; Synergistota; Synergistia; Synergistales; Synergistaceae;
OC Aminomonas.
OX NCBI_TaxID=584708 {ECO:0000313|EMBL:EFQ23125.1, ECO:0000313|Proteomes:UP000005096};
RN [1] {ECO:0000313|EMBL:EFQ23125.1, ECO:0000313|Proteomes:UP000005096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12260 {ECO:0000313|EMBL:EFQ23125.1,
RC ECO:0000313|Proteomes:UP000005096};
RX PubMed=21304733;
RA Pitluck S., Yasawong M., Held B., Lapidus A., Nolan M., Copeland A.,
RA Lucas S., Del Rio T.G., Tice H., Cheng J.F., Chertkov O., Goodwin L.,
RA Tapia R., Han C., Liolios K., Ivanova N., Mavromatis K., Ovchinnikova G.,
RA Pati A., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J.,
RA Jeffries C.D., Pukall R., Spring S., Rohde M., Sikorski J., Goker M.,
RA Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P.;
RT "Non-contiguous finished genome sequence of Aminomonas paucivorans type
RT strain (GLU-3).";
RL Stand. Genomic Sci. 3:285-293(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CM001022; EFQ23125.1; -; Genomic_DNA.
DR RefSeq; WP_006300289.1; NZ_CM001022.1.
DR AlphaFoldDB; E3CUP5; -.
DR STRING; 584708.Apau_0697; -.
DR REBASE; 29865; M2.Apa12260I.
DR PaxDb; 584708-Apau_0697; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_013049_4_2_0; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000005096; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42933:SF3; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:EFQ23125.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005096};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW Transferase {ECO:0000313|EMBL:EFQ23125.1}.
FT DOMAIN 7..134
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 146..451
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 507 AA; 57403 MW; ABCF06DA8DDA4D8A CRC64;
MISQSQLEAY LWGAATLLRG TIDAGDYKQF IFPLLFYKRL CDVYDEELAD ALEESGGDRE
YAALPEQHRF QIPEDAHWKA TRTQVKNVGK AIQDALRAIE TANPDTLYGV FGDAQWTNKD
RLPDRMLREL IEHFSSQTLS LAHCPEDELG VGYEFLIKQF ADDSGHTAAE FYTNRTVVHL
MTEMLEPKPG ESIYDPTCGS AGMLLSAVAH LKRQNKEWRN LRLYGQERNL LTSAIGRMNL
FLHGIEDFRL VRGDTLAGPA FVEGDRLMQF DVVLANPPYS IKQWDRDAWS ADPWGRNIYG
TPPQGRADYA FWQHIIKSMK EDTGRCAILF PHGVLFRNEE LAMREKLVGH DVVECVLGLG
PNLFYNSPME ACVVICRMNK PKERRGKVLF LNAVNEVTRE RAQSFLTEEH ILRIVAAYRS
FTDEDSFARV VSTEEIAAKG SNLSIPLYVR VDHGHGNGNG AAETISLKET IVHWQESSMV
LRESMDGLFS VLENDYPQSP QDSTDAK
//