ID E3D752_GARV3 Unreviewed; 356 AA.
AC E3D752;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Endonuclease/exonuclease/phosphatase family protein {ECO:0000313|EMBL:ADP39222.1};
GN OrderedLocusNames=HMPREF0421_21140 {ECO:0000313|EMBL:ADP39222.1};
OS Gardnerella vaginalis (strain ATCC 14019 / 317).
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Gardnerella.
OX NCBI_TaxID=525284 {ECO:0000313|EMBL:ADP39222.1, ECO:0000313|Proteomes:UP000001453};
RN [1] {ECO:0000313|EMBL:ADP39222.1, ECO:0000313|Proteomes:UP000001453}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14019 / 317 {ECO:0000313|Proteomes:UP000001453};
RX PubMed=20865041; DOI=10.1371/journal.pone.0012411;
RA Yeoman C.J., Yildirim S., Thomas S.M., Durkin A.S., Torralba M., Sutton G.,
RA Buhay C.J., Ding Y., Dugan-Rocha S.P., Muzny D.M., Qin X., Gibbs R.A.,
RA Leigh S.R., Stumpf R., White B.A., Highlander S.K., Nelson K.E.,
RA Wilson B.A.;
RT "Comparative genomics of Gardnerella vaginalis strains reveals substantial
RT differences in metabolic and virulence potential.";
RL PLoS ONE 5:E12411-E12411(2010).
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DR EMBL; CP002104; ADP39222.1; -; Genomic_DNA.
DR RefSeq; WP_009994865.1; NC_014644.1.
DR RefSeq; YP_003986245.1; NC_014644.1.
DR AlphaFoldDB; E3D752; -.
DR KEGG; gvg:HMPREF0421_21140; -.
DR PATRIC; fig|525284.18.peg.1120; -.
DR HOGENOM; CLU_052333_1_1_11; -.
DR OrthoDB; 2340043at2; -.
DR Proteomes; UP000001453; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000313|EMBL:ADP39222.1};
KW Exonuclease {ECO:0000313|EMBL:ADP39222.1};
KW Hydrolase {ECO:0000313|EMBL:ADP39222.1};
KW Membrane {ECO:0000256|SAM:Phobius}; Nuclease {ECO:0000313|EMBL:ADP39222.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 40..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 122..345
FT /note="Endonuclease/exonuclease/phosphatase"
FT /evidence="ECO:0000259|Pfam:PF03372"
SQ SEQUENCE 356 AA; 39289 MW; 164DE478EE1A83DF CRC64;
MIYAILLAIL LVALVLLLAW QLLRWLPAGA DRLKPLPYVI ALLPIAPFCA ALGLVVSAVA
AVATRSQNEF YKSYLFLCVA YALLFVISLK SYTPYWAVRL RRIKQEKSPE LSLEKSREIR
VMTLNCRYGR ANASQIIKLA KTHKIDTILL QEVSKKLVKN LEKLGIKRDF AHVQLGSANG
HENGGFNAIY TRLSNVKSFG KSIKIDAANV PIVTAVTRDS SAENLLITFA SAHPKSPMRG
CAAWSSGIMA LAKIGENHNE NNVKDVKKVK IIGGDLNSTP DHPSFRALLK SGFLDASMQI
GKRLKTWPTW QKWPNLALDH VLVKSTGCNA IATEQRAIRV DGSDHFALIV CVSIHI
//
