ID   E3DA26_GARV3            Unreviewed;       319 AA.
AC   E3DA26;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   RecName: Full=Probable hydrogen peroxide-inducible genes activator {ECO:0000256|ARBA:ARBA00040885};
GN   OrderedLocusNames=HMPREF0421_20838 {ECO:0000313|EMBL:ADP38920.1};
OS   Gardnerella vaginalis (strain ATCC 14019 / 317).
OC   Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC   Bifidobacteriaceae; Gardnerella.
OX   NCBI_TaxID=525284 {ECO:0000313|EMBL:ADP38920.1, ECO:0000313|Proteomes:UP000001453};
RN   [1] {ECO:0000313|EMBL:ADP38920.1, ECO:0000313|Proteomes:UP000001453}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14019 / 317 {ECO:0000313|Proteomes:UP000001453};
RX   PubMed=20865041; DOI=10.1371/journal.pone.0012411;
RA   Yeoman C.J., Yildirim S., Thomas S.M., Durkin A.S., Torralba M., Sutton G.,
RA   Buhay C.J., Ding Y., Dugan-Rocha S.P., Muzny D.M., Qin X., Gibbs R.A.,
RA   Leigh S.R., Stumpf R., White B.A., Highlander S.K., Nelson K.E.,
RA   Wilson B.A.;
RT   "Comparative genomics of Gardnerella vaginalis strains reveals substantial
RT   differences in metabolic and virulence potential.";
RL   PLoS ONE 5:E12411-E12411(2010).
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000256|ARBA:ARBA00009437}.
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DR   EMBL; CP002104; ADP38920.1; -; Genomic_DNA.
DR   RefSeq; YP_003985943.1; NC_014644.1.
DR   AlphaFoldDB; E3DA26; -.
DR   KEGG; gvg:HMPREF0421_20838; -.
DR   PATRIC; fig|525284.18.peg.827; -.
DR   HOGENOM; CLU_039613_6_4_11; -.
DR   OrthoDB; 3181812at2; -.
DR   Proteomes; UP000001453; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd08411; PBP2_OxyR; 1.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR30346:SF26; HYDROGEN PEROXIDE-INDUCIBLE GENES ACTIVATOR; 1.
DR   PANTHER; PTHR30346; TRANSCRIPTIONAL DUAL REGULATOR HCAR-RELATED; 1.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
FT   DOMAIN          21..78
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50931"
SQ   SEQUENCE   319 AA;  36096 MW;  05F14731D18BEBA9 CRC64;
     MILKIYIYYI LTTFNKKDDY VNIKSLEYLI AFAKEESFTK AAERMHVSQP TLSTQIKKLE
     DLLGVCLIER TPGKQILTPA GREVVYYAKR IHADVSSIYQ AARRLEDPWS STIVLGVFPT
     LCPYLLPRIM PVLRKVKPNF NIRFVEEKSA SLVEMLHSGQ IDGAILSEQL NESSLKVKHI
     FDEDFLLAAS TNSQFGHEKT PIDVSQLSSQ KVLLLEDGHC MRRSMIDVCQ KVGAKQSEFY
     ATSLETLRYM VVGSKDVTLL PRLSILPPIV QPSGLTIREF KDPKPYRSLY LNWRAASPVD
     QIMDGLAKII SGACVNLHK
//