ID E3DPB1_HALPG Unreviewed; 424 AA.
AC E3DPB1;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Radical SAM domain protein {ECO:0000313|EMBL:ADO76662.1};
GN OrderedLocusNames=Hprae_0508 {ECO:0000313|EMBL:ADO76662.1};
OS Halanaerobium praevalens (strain ATCC 33744 / DSM 2228 / GSL).
OC Bacteria; Bacillota; Clostridia; Halanaerobiales; Halanaerobiaceae;
OC Halanaerobium.
OX NCBI_TaxID=572479 {ECO:0000313|EMBL:ADO76662.1, ECO:0000313|Proteomes:UP000006866};
RN [1] {ECO:0000313|Proteomes:UP000006866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33744 / DSM 2228 / GSL
RC {ECO:0000313|Proteomes:UP000006866};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA Ovchinnikova G., Chertkov O., Detter J.C., Han C., Larimer F., Land M.,
RA Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA Tindall B., Pomrenke H.G., Brambilla E., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Halanaerobium praevalens DSM 2228.";
RL Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADO76662.1, ECO:0000313|Proteomes:UP000006866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33744 / DSM 2228 / GSL
RC {ECO:0000313|Proteomes:UP000006866};
RX PubMed=21886858;
RA Ivanova N., Sikorski J., Chertkov O., Nolan M., Lucas S., Hammon N.,
RA Deshpande S., Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S.,
RA Huntemann M., Liolios K., Pagani I., Mavromatis K., Ovchinikova G.,
RA Pati A., Chen A., Palaniappan K., Land M., Hauser L., Brambilla E.M.,
RA Kannan K.P., Rohde M., Tindall B.J., Goker M., Detter J.C., Woyke T.,
RA Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA Klenk H.P., Lapidus A.;
RT "Complete genome sequence of the extremely halophilic Halanaerobium
RT praevalens type strain (GSL).";
RL Stand. Genomic Sci. 4:312-321(2011).
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DR EMBL; CP002175; ADO76662.1; -; Genomic_DNA.
DR RefSeq; WP_014552695.1; NC_017455.1.
DR AlphaFoldDB; E3DPB1; -.
DR STRING; 572479.Hprae_0508; -.
DR KEGG; hpk:Hprae_0508; -.
DR PATRIC; fig|572479.3.peg.512; -.
DR eggNOG; COG4277; Bacteria.
DR HOGENOM; CLU_033784_0_0_9; -.
DR OrthoDB; 9801154at2; -.
DR Proteomes; UP000006866; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 1.10.150.320; Photosystem II 12 kDa extrinsic protein; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR023874; DNA_rSAM_put.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR010994; RuvA_2-like.
DR NCBIfam; TIGR03916; rSAM_link_UDG; 1.
DR PANTHER; PTHR21180; ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR21180:SF9; RADICAL SAM DOMAIN PROTEIN; 1.
DR Pfam; PF12836; HHH_3; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SFLD; SFLDG01102; Uncharacterised_Radical_SAM_Su; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000006866};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 185..204
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT DOMAIN 331..350
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
SQ SEQUENCE 424 AA; 47711 MW; 34C2F50E9B63B607 CRC64;
MELQKKLEIL SDAAKYDVSC SASGSSGRGN SSSLGNTSVG GICHSWTADG RCVSLLKILF
TNHCIYDCQY CINRASNDRP RASFTPVEVA KLTIDFYKRN YIEGLFLSSA VNKNPDWTME
QLLKTVQLLR NKHNYQGYIH LKAIPGADFK LIYQAGLLAD RMSVNIELPS ETSLAKLAPQ
KKKAGILAPM KGIGEKIANN IIERKKYKLK DKFVPAGQST QLIVGASPES DKQIISLSEG
LYNNFNLKRV YYSAYLPVNK SSLLPTLTGP PLKREHRLYQ ADWLLRFYGF KAGELLTPDR
ENFDLKIDPK ADWAINNLDQ FPIEVNQASY QMLLRVPGIG PRSAAKIVKA RKEKKLNHYN
LKKLRIVLKR ANFFITCNGK YAAAVPFKKS VIYNRLAEKE SQQLSLFGAE DSNRSEKAWD
LEQA
//
