ID E3FDL4_STIAD Unreviewed; 781 AA.
AC E3FDL4;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN OrderedLocusNames=STAUR_2289 {ECO:0000313|EMBL:ADO70093.1};
OS Stigmatella aurantiaca (strain DW4/3-1).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Archangiaceae; Stigmatella.
OX NCBI_TaxID=378806 {ECO:0000313|EMBL:ADO70093.1, ECO:0000313|Proteomes:UP000001351};
RN [1] {ECO:0000313|EMBL:ADO70093.1, ECO:0000313|Proteomes:UP000001351}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DW4/3-1 {ECO:0000313|EMBL:ADO70093.1,
RC ECO:0000313|Proteomes:UP000001351};
RX PubMed=21037205; DOI=10.1093/molbev/msq292;
RA Huntley S., Hamann N., Wegener-Feldbrugge S., Treuner-Lange A., Kube M.,
RA Reinhardt R., Klages S., Muller R., Ronning C.M., Nierman W.C.,
RA Sogaard-Andersen L.;
RT "Comparative genomic analysis of fruiting body formation in Myxococcales.";
RL Mol. Biol. Evol. 28:1083-1097(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP002271; ADO70093.1; -; Genomic_DNA.
DR AlphaFoldDB; E3FDL4; -.
DR STRING; 378806.STAUR_2289; -.
DR KEGG; sur:STAUR_2289; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_004585_5_2_7; -.
DR Proteomes; UP000001351; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 17..296
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 297..602
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 687..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..718
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 38..45
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 781 AA; 86590 MW; 571AB9E41772A05A CRC64;
MPSPGPALNT HEQALLEDLN PPQKEAVLHG EGPLLVLSGA GSGKTRVITR RVAHLVKVRR
VFPWRILAVT FTNKAAREMR ERLVQLLGAQ AHELVVSTFH SSAAMILRRE AEAVGLTRSF
VIYDDGDQLN IVKRAMREAR VEPSMQPREI LHRIDQEKNA ARLPDAMQVD ADDLRGMVVK
RTYQTYQRLL RAANAVDFGD LLLLLVSLFR DHPEVLEKYR RRFSHVLVDE FQDTNPVQYE
LLRLLAPPPG ANLVVVGDDD QSIYRWRGAS VDNILGFPNT YPGAKVVKLE QNYRSDQAIL
EAAHAVISKN RRRMAKKLWS ERQRGEHLQL LILRDERAEA QEVARQIHAL QREGFIKYSG
MAVFYRVNAQ SRVLEEALRL ARVPYTLVSG RSFYDRAEVR DAAAYLRLMV NPRSDADLLR
IINTPARGIG DTTVERLTTH ADHQGISLYE AIAQPEQIPA LNSAAVRRLA GVHTLLASLN
SFAQGAKDAA SAVDEMLRET RLVESLTAEG SDESLTRAEN LREFLGAAQE FDLNRAAASV
AAAAAVPAEP EEPLPADLDA APLSADVPPL QSFLEQISLV GDADAEVGEG KVALMTLHAA
KGLEFDAVFL TGMEDNVFPH SRALVGEDPD EGEEMAEERR LCYVGFTRAR RRLFVSLAQC
RSLFGELRYN PPSRFLRDVP PTLFGIDPSV QEAPRPVAAP VAPRRRSYED DDSPRIDRSY
SQAPDMEGAS GDVRGMRVRH EQFGVGRIVS TDGSGPNAKV TVEFGGGVGL KRVIARFLLP
G
//
