ID E3FE21_STIAD Unreviewed; 3228 AA.
AC E3FE21;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=GrsB-like Gramicidin S synthetase 2 {ECO:0000313|EMBL:ADO72624.1};
GN OrderedLocusNames=STAUR_4846 {ECO:0000313|EMBL:ADO72624.1};
OS Stigmatella aurantiaca (strain DW4/3-1).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Archangiaceae; Stigmatella.
OX NCBI_TaxID=378806 {ECO:0000313|EMBL:ADO72624.1, ECO:0000313|Proteomes:UP000001351};
RN [1] {ECO:0000313|EMBL:ADO72624.1, ECO:0000313|Proteomes:UP000001351}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DW4/3-1 {ECO:0000313|EMBL:ADO72624.1,
RC ECO:0000313|Proteomes:UP000001351};
RX PubMed=21037205; DOI=10.1093/molbev/msq292;
RA Huntley S., Hamann N., Wegener-Feldbrugge S., Treuner-Lange A., Kube M.,
RA Reinhardt R., Klages S., Muller R., Ronning C.M., Nierman W.C.,
RA Sogaard-Andersen L.;
RT "Comparative genomic analysis of fruiting body formation in Myxococcales.";
RL Mol. Biol. Evol. 28:1083-1097(2011).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP002271; ADO72624.1; -; Genomic_DNA.
DR RefSeq; WP_013376474.1; NC_014623.1.
DR STRING; 378806.STAUR_4846; -.
DR KEGG; sur:STAUR_4846; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_0_0_7; -.
DR OrthoDB; 5349841at2; -.
DR Proteomes; UP000001351; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd12117; A_NRPS_Srf_like; 1.
DR CDD; cd19531; LCL_NRPS-like; 3.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 3.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 992..1067
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2059..2134
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3125..3200
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 3228 AA; 354901 MW; 947845C5E120FB4D CRC64;
MTTESARNLS VQSPELPSVV SDEVHVFPMS IGQRQIWLSE QLVPGTALYS VPAAIRLSGH
LKVTALEQAL QQIVARHESL RTTFTEAGSE LLQVIHPERA HRLERHELGA LAPSEQEETL
ARLSQEEGRQ PFDLVQGPLL RTKLVRLAET EHVLLLTLHH IIADGWSAGV LIHELRALYG
ALVREQPPVL PELSIQYVDY AAWQQEHLTG DQKDALVSFW KQRLEGSPAV IALPTDRPRP
KVRGYQGASQ PIEFSRSLVE GLRTLAREEN ATLYMALLAA FQVLLSRSTG QADIVVGGSV
ANRNMPGTEG LIGYLANIVP LRVDLSGEPS FREVLRRVRE TALEAYAHQE LPLGMLIEEL
MPERSLGHTP IFQVIFTLTE SFDDQFGMTG LATQVSEIDT GTAKYDLSLL LAEGRDGGVR
GRLEYSTELY DRPKVEGLVR QLKEVLEQGV ARPGERVGKL ALVRGEERQR LLAQGQGQEG
GYPREASIGQ VFEQVVARAP QAVAVTGGGK ELSYAALNHR AEQVARRLKA KGVGPEQVVA
LVMERSVELV EAMVGVVKAG GAYLPLDPKL PGERLEYMLK DAGARVVVTQ AEWQERVRGE
GWDVVVLEEE EPAEEGSWAP VAVDANSLAY VMYTSGSTGQ PKGVAVTQRG VVRLVCGTDF
LQVSAEDRFL HLATPSFDAS TLEIWGALLN GAQLVVAPAQ QLTLEELRLL LEVERISVLW
LTAGLFHQMA DEYPDVLGGV RQVLAGGDVL SPVHVKRVLE EGMGGRLING YGPTENTTFT
CCHVMETPEQ AGPPVPIGRP IAQTGVYVLD EEMQPVPEGV VGELYTGGDG LARGYVGRPE
LTAEKFVPNP YGKQAGQRLY RTGDLARWRG DGSLEFVGRA DTQVKVRGFR IEIGEVEGAL
ESHPEVKAAA VVVQGEGAEG KRLVGFVVGG GRKVEVGEVR GYLEKRLPEY MVPSLLVEVE
KLPLTGNGKV DRKALLAQVS EQGAGASSNY VAPRDETEQK LAELWEELLG LNRVGIHDDF
FEAGGHSLLA TQLGSRIREQ FGVELALRQL FENSTIAELA GLIAKSAPAP STGAEAPIRA
VPRGEELPLS HTQRRLWVLD QIEPGSPLYN VAGTVSMSGE LDVEALTLSL SEVVARHEAL
RTSFVEKAGQ PFQRIHPPAP FSLVTKDLSG LEPAARQAEA RRLSAEWAQR PFDLTQAPLL
RAMLLRLEET EHQLLLSNHH IISDGWSVGV LIREMAACYS AFMEGRRPEL PELPIQYADY
AAWQTEWLRG ERLEAQLSFW KKHLAGASLA LDLPTDRPRP AVQSFRGDQL SITLPAALAE
QLRAFSREHG VTLFMTLFAG FNALLSRYSR QEDVVVGTTI ANRTRRELEG LIGFFVNTLA
IRTDLSGAPR FTELLERVRQ TMLAAYGHQD APFELVVDAV QPKRDLSRTP VFQVLFDLLN
SPKPRLTLPG LELSVREAET GASKFDLSVQ MEDTEAGLTA VIEYNTELYE RKTVERLMSH
YQVLLKGAVE QPEKRLWQLP VLGEGERRTV LEKWNQTGRE EGSELFCELF EKQVEKTPEA
VAVVCGEQAL SYRQLNAQAN RVAHALKARG AGLEKVVGVV QERGVGYLVS LLGVLKADAV
YLPLDPALPA SRLAGLVKQS GCQWVLSEEK TRGLAQEIAQ GQPVLEREGV LAEGRGEHNP
KHEVEPKSLA YVLYTSGSTG VPKGAMIEHR GMKNHLMAKV RDLGMGLEEV VAQVAVQSFD
VSVWQFLSAL LSGGRTAVFP DESAWEPQKL LKEMGRQGVT LLETVPAHMK LILEELEARP
NEYDVSALKW FFLNGEALPA ELCQRWFERY PGIPMVNAYG PTECSDDVTH YKMMKAPQQK
QGWMPIHGTL PNLQLYVVDE WIQPVPLGVP GELCVGGVGV GRGYLGDAVK TAGSYVPNPF
ASQAGERLYR TGDLVRCLED GTLEFLGRND HQVKIRGIRI ELGEIEAALR KHPRVGMCVV
VARAEGQGKR LVGYVSAKEA GAQPTGKELT EYLKGQLTAA MVPSAMVVME ALPLTHNGKV
DRKALPAPEY GTERAEYVAP RTEMEKKLAG IWQEVLGVPR VGVTDNFFDL GGHSLIAIQV
ISRVREAARV ELPVRALFEE PTVSGLAARL ETLAVAGGTS SLPPVVPMPR GEVAPLSYAQ
QRLWVLGQLE PHSPLYNVPG ALRLTGQLNV DALERSLSEI VTRHDALRTT FELEGSQPAQ
RIGKAGSIPL EVVDLSHLEP GARAVELQRM GGEEARKPFD LGRGPLMRAR LLKLEPSEHV
LLLTMHHIVS DGWSVGVFFR ELGALYGAFS AGQPSPLSAL KVQYADYAQW QRQWLKGETL
DKHLGYWKKQ LAGVEPLDLK TDRPRGPMQG ARGDRYLFRL PKELEEGLKA LSRKQGTTLF
MTLLAGFNAL LARYTRQQDI VVGTSVANRG QAEIEELIGF FVNTLALRTQ VDGNPRFTEL
LERVRKVTLE AYTHQEAPFD RVVEAVQPER DLTRTPLFQV AFELQKAPTA SLKLEGLTLG
LEELTTETSK FDLLLTMIEG PEGLHGGVEY NTELYERKTV ERLMSHYQVL LKGAVEQPEK
RLWQLPVLGE GERQTVLEKW NQTGREEGPE LFCELFEKQV EKTPEAVAVV CGEQALSYRQ
LNAQANRVAH ALKARGAGLE KVVGVVQERG VGYLVSLLGV LKADAVYLPL DPALPASRLA
GLVKQSGCQW VLSEEKTRGL AQEIAQGQPV LEREGVLAEG RGEHNPKHEV EPKSLAYVLY
TSGSTGVPKG AMIEHRGMKN HLMAKVRDLG MGPEEVVAQV AVQSFDVSVW QFLSALLSGG
RTAVFPDESA WEPQKLLKEM GRQGVTLLET VPAHMKLILE ELEARPNEYD VSALKWFFLN
GEALPAELCQ RWFERYPGIP MVNAYGPTEC SDDVTHYKMM KAPQQKQGWM PIHGTLPNLQ
LYVVDEWIQP VPLGVPGELC VGGVGVGRGY LGDAVKTAGS YVPNPFASQA GERLYRTGDL
VRCLEDGTLE FLGRNDHQVK IRGIRIELGE IEAALRKHPR VGMCVVVARA EGQGKRLVGY
VSAKEAGAQP TGKELTEYLK GQLTAAMVPS AMVVMEALPL THNGKVDRKA LPAPEYGTER
AEYVAPRTEM EKKLAGIWQE VLGVPRVGVT DNFFDLGGHS LMAIQIISKV RQELQAELPV
VTLFENATVA GIAARLEALP KGAPELEAPP LIAVSRYEDD DEEEEEEE
//
