ID E3GP35_9FIRM Unreviewed; 877 AA.
AC E3GP35;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 24-JAN-2024, entry version 79.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:NZA38821.1};
GN OrderedLocusNames=ELI_2658 {ECO:0000313|EMBL:ADO37639.1};
GN ORFNames=H0N91_11950 {ECO:0000313|EMBL:NZA38821.1};
OS Eubacterium callanderi.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Eubacterium.
OX NCBI_TaxID=53442 {ECO:0000313|EMBL:ADO37639.1, ECO:0000313|Proteomes:UP000006873};
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=KIST612;
RA Roh H., Ko H.-J., Kim D., Choi D.G., Park S., Kim S., Kim K.H., Chang I.S.,
RA Choi I.-G.;
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADO37639.1, ECO:0000313|Proteomes:UP000006873}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIST612 {ECO:0000313|EMBL:ADO37639.1,
RC ECO:0000313|Proteomes:UP000006873};
RX PubMed=21036996; DOI=10.1128/JB.01217-10;
RA Roh H., Ko H.J., Kim D., Choi D.G., Park S., Kim S., Chang I.S., Choi I.G.;
RT "Complete genome sequence of a carbon monoxide-utilizing acetogen,
RT Eubacterium limosum KIST612.";
RL J. Bacteriol. 193:307-308(2011).
RN [3] {ECO:0000313|EMBL:NZA38821.1, ECO:0000313|Proteomes:UP000586254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AMC0717 {ECO:0000313|EMBL:NZA38821.1,
RC ECO:0000313|Proteomes:UP000586254};
RA Marsh A.J., Azcarate-Peril M.A.;
RT "Organ Donor 1.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP002273; ADO37639.1; -; Genomic_DNA.
DR EMBL; JACCKS010000013; NZA38821.1; -; Genomic_DNA.
DR RefSeq; WP_013380960.1; NZ_JANGDA010000006.1.
DR AlphaFoldDB; E3GP35; -.
DR GeneID; 68363703; -.
DR KEGG; elm:ELI_2658; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_1_3_9; -.
DR Proteomes; UP000006873; Chromosome.
DR Proteomes; UP000586254; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 696..712
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 622..629
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 877 AA; 99082 MW; 4BF0B0EA1F33B325 CRC64;
MGLTPMMQQY LETHEKVKDA ILFFRLGDFY EMFFDDALKA SKELEIALTG RDCGLDERAP
MCGVPYHAAE SYITKLVEKG YKVAICEQME DPSVAKGIVK REIIRVISPG TIAEGKLLES
KKNNYLMSLY QEKNTIGLAY LDISTGDFFV TEISGKNTLA LLMDEVGKIG PSEILVNPTL
FKDTGTIKTL EEKFGIMTNL YPARYFEFKA SESRLKEQFD VYSLTALDLE RREHSVRAAG
ALLRYIDETQ KRVLTHINHV SYYKNDEYMI LDLSTRRNLE LTETIRSGEK KGSLLWVLDK
TVTAMGGRML RRWLEAPLLE KKAIEARQDM VEELYRHPGA LKDLKGVLGK VYDLERICGK
ISFGTCNPKD MLSLKQSVSA LPLLQAFFAG IDAPVFRKRY GEADLLTDIY ELIDASIDDN
APFALKDGKV IKRGYNEEID GYREASEKGK DWIRDLELKE RERTGIKSLK VKYNRVFGYF
IEITKTNLDQ TPEDYIRKQT LANAERFFTP ELKEMETRIL GSEERLAQLE YELFQDVREK
IIAQIARIQK RARDVAEIDA LYSLAQVAIA GNYVKPEITN GPELEIENGR HPVVEEIIGI
NHFVTNGCHF DGKDLRMMLI TGPNMAGKST YIRQVAVIAL MAQIGSFIPA DSGRIGIVDR
IFTRVGASDD LATGQSTFMV EMTEVSNILK NATQDSLVIL DEIGRGTSTF DGISIAWAVV
EYLWDEQIIG AKTLFATHYH ELTELEHLKP GIKNFSIGVR ETPEGVVFLR KIKPGSADQS
YGIEVARLAG FPPAVTNRAR EILNILDQGE DTYREGMIAA EKPSFESAQI NFFDRIPAMS
EEEKAVLNSI KDLSINEMTP MEAMNQLYGL QSKLKDN
//