ID   E3GPC8_9FIRM            Unreviewed;       624 AA.
AC   E3GPC8; A0A1M7A509;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   SubName: Full=NDP-sugar epimerase, includes UDP-GlcNAc-inverting 4,6-dehydratase FlaA1 and capsular polysaccharide biosynthesis protein EpsC {ECO:0000313|EMBL:SFP03638.1};
GN   OrderedLocusNames=ELI_3080 {ECO:0000313|EMBL:ADO38049.1};
GN   ORFNames=SAMN04487888_106304 {ECO:0000313|EMBL:SFP03638.1};
OS   Eubacterium callanderi.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC   Eubacterium.
OX   NCBI_TaxID=53442 {ECO:0000313|EMBL:ADO38049.1, ECO:0000313|Proteomes:UP000006873};
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KIST612;
RA   Roh H., Ko H.-J., Kim D., Choi D.G., Park S., Kim S., Kim K.H., Chang I.S.,
RA   Choi I.-G.;
RL   Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADO38049.1, ECO:0000313|Proteomes:UP000006873}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIST612 {ECO:0000313|EMBL:ADO38049.1,
RC   ECO:0000313|Proteomes:UP000006873};
RX   PubMed=21036996; DOI=10.1128/JB.01217-10;
RA   Roh H., Ko H.J., Kim D., Choi D.G., Park S., Kim S., Chang I.S., Choi I.G.;
RT   "Complete genome sequence of a carbon monoxide-utilizing acetogen,
RT   Eubacterium limosum KIST612.";
RL   J. Bacteriol. 193:307-308(2011).
RN   [3] {ECO:0000313|EMBL:SFP03638.1, ECO:0000313|Proteomes:UP000199443}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NLAE-zl-G225 {ECO:0000313|EMBL:SFP03638.1,
RC   ECO:0000313|Proteomes:UP000199443};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC       {ECO:0000256|ARBA:ARBA00007430}.
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DR   EMBL; CP002273; ADO38049.1; -; Genomic_DNA.
DR   EMBL; FOWI01000006; SFP03638.1; -; Genomic_DNA.
DR   RefSeq; WP_013381367.1; NZ_QYRZ01000020.1.
DR   AlphaFoldDB; E3GPC8; -.
DR   GeneID; 68364057; -.
DR   KEGG; elm:ELI_3080; -.
DR   eggNOG; COG1086; Bacteria.
DR   HOGENOM; CLU_013560_5_2_9; -.
DR   Proteomes; UP000006873; Chromosome.
DR   Proteomes; UP000199443; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003869; Polysac_CapD-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR43318:SF1; POLYSACCHARIDE BIOSYNTHESIS PROTEIN EPSC-RELATED; 1.
DR   PANTHER; PTHR43318; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE; 1.
DR   Pfam; PF13727; CoA_binding_3; 1.
DR   Pfam; PF02719; Polysacc_synt_2; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        49..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        80..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        107..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          286..576
FT                   /note="Polysaccharide biosynthesis protein CapD-like"
FT                   /evidence="ECO:0000259|Pfam:PF02719"
SQ   SEQUENCE   624 AA;  70636 MW;  08A82A1E53FEC764 CRC64;
     MKKDSKDMAV RVAFLIFLDA VVLFLSYLFA FLLTYNFKIP FNFVSGARWF LAMGIGIKVV
     VFFITGMYNT LWRYASIEEL WQITFSVILA NILTFVLYFA IGAGVPTTVQ ILSFVFDLIM
     VGAIRIFYRT GRRIKQGVGG KGNSRNVLIV GAGEAGIKIL RELAAGEMKS YVVGFVDDNV
     YKQKKKINGL TVLGGREDIP DIVEDEQVNE IIIALPSVPK KEMNEIAEIC HKTGRPVRVL
     PSFDDILNYD VSLSKLRDLQ IEDLLDRDEI HLDKSVISEF IRGKVVLVTG GAGSIGSELC
     RQIIKYQPKQ LVILDIYENT LYYLELELRR YIHELEIESG YGIRLDLEIT SIRDKASVNS
     LFERYRPQVV FHAAAHKHVP LMEKTPKEAV KNNIFGTRNV LDACVEYQVE KFVQISTDKA
     VKPTNVMGTT KRICEMLIQL YDQHNQTEFV AVRFGNVLGS NGSVIPIFKE QIANGGPLTV
     THPDIERFFM TIPEATQLVL QAGSIAHGGE IFVLDMGEPV KIKDLAERMV RLSGYEPYTE
     MPIVFSGLRP GEKLYEELSY DMAEFDKTRY KDIFVEKPEV FDEIVICDEL EKLKQIVDGG
     TMSEVIDQLK VIVPDYHPNR ETAI
//