ID E3GYW1_METFV Unreviewed; 685 AA.
AC E3GYW1;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Formate dehydrogenase, alpha subunit (F420) {ECO:0000313|EMBL:ADP77493.1};
DE EC=1.2.99.- {ECO:0000313|EMBL:ADP77493.1};
GN OrderedLocusNames=Mfer_0694 {ECO:0000313|EMBL:ADP77493.1};
OS Methanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanothermaceae; Methanothermus.
OX NCBI_TaxID=523846 {ECO:0000313|EMBL:ADP77493.1, ECO:0000313|Proteomes:UP000002315};
RN [1] {ECO:0000313|EMBL:ADP77493.1, ECO:0000313|Proteomes:UP000002315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43054 / DSM 2088 / JCM 10308 / V24 S
RC {ECO:0000313|Proteomes:UP000002315};
RX PubMed=21304736;
RA Anderson I., Djao O.D., Misra M., Chertkov O., Nolan M., Lucas S.,
RA Lapidus A., Del Rio T.G., Tice H., Cheng J.F., Tapia R., Han C.,
RA Goodwin L., Pitluck S., Liolios K., Ivanova N., Mavromatis K.,
RA Mikhailova N., Pati A., Brambilla E., Chen A., Palaniappan K., Land M.,
RA Hauser L., Chang Y.J., Jeffries C.D., Sikorski J., Spring S., Rohde M.,
RA Eichinger K., Huber H., Wirth R., Goker M., Detter J.C., Woyke T.,
RA Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P.,
RA Kyrpides N.C.;
RT "Complete genome sequence of Methanothermus fervidus type strain (V24S).";
RL Stand. Genomic Sci. 3:315-324(2010).
CC -!- COFACTOR:
CC Name=Mo-bis(molybdopterin guanine dinucleotide);
CC Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP002278; ADP77493.1; -; Genomic_DNA.
DR RefSeq; WP_013413771.1; NC_014658.1.
DR AlphaFoldDB; E3GYW1; -.
DR SMR; E3GYW1; -.
DR STRING; 523846.Mfer_0694; -.
DR GeneID; 9962424; -.
DR KEGG; mfv:Mfer_0694; -.
DR HOGENOM; CLU_000422_4_0_2; -.
DR OrthoDB; 23466at2157; -.
DR Proteomes; UP000002315; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0008863; F:formate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0015942; P:formate metabolic process; IEA:InterPro.
DR CDD; cd02790; MopB_CT_Formate-Dh_H; 1.
DR CDD; cd02753; MopB_Formate-Dh-H; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR041925; CT_Formate-Dh_H.
DR InterPro; IPR041924; Formate_Dh-H_N.
DR InterPro; IPR006478; Formate_DH_asu.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR InterPro; IPR006655; Mopterin_OxRdtase_prok_CS.
DR NCBIfam; TIGR01591; Fdh-alpha; 1.
DR PANTHER; PTHR43105:SF15; FORMATE DEHYDROGENASE H; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF04879; Molybdop_Fe4S4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR PROSITE; PS00490; MOLYBDOPTERIN_PROK_2; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:ADP77493.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002315}.
FT DOMAIN 5..61
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
SQ SEQUENCE 685 AA; 76208 MW; 101CF786DEFE94B1 CRC64;
MSFELKYTPN ICPYCGCGCG LNIVTLNGKI KGVEGWKRHP VNEGKLCPKG NFSYQFVQSK
DRLKHPLIKK NGKFIEISWD KAVDIIVSKL NEYRKENPNS IAFLASARCT NEENYILQKF
ARVAIGTNNI DHCARLCHAP SVAGLAQTFG SGAMTNSILD IEEAESIFII GSNTAEQHPI
IWRRVLKAKN KGAKLIVADP RKTPTASLAD IHLPIKPGSN IALINAMMNV IIEEGLEDTD
FIKKRTKGFE KLKEVIEKYK PEKVEKIVGV PAKKIREAAI TYAKADRATI LYAMGITQHT
TGTHNVISTA NLAMLTGNIG KKGTGVNPLR GQNNVQGACD MGALPQFYPG YQKVTDKNAT
EKMQKIWKCD DLSSEPGLTV VEMMDAAIDG KVKCMYIMGE NPVLSDPDIK HVKKALKNLE
FLIVQDIFLT ETAEFADIVL PTTAWGEKNG TYTSTERRVQ CIRKAADGPG EAKDDWRIIC
EIAKRMNVNG FEFNSTKEIF NEIRKVTPQY AGMNFKRLQK PGGLQWPCPD ESHPGTPILH
TEKFATPDGL GKFIPVEHEE PAELPDDRYP FILTTGRILF HYHTGTMTRR SETLDNEVST
GFVEINDKDA SKLGIKDGEI VKVMTRRGEI KIPAKVTSKV REGVLFIPFH FVECAANMLT
STNYDPISKI PEFKVSAANI EKLED
//
