ID   E3H0C0_ROTDC            Unreviewed;       305 AA.
AC   E3H0C0;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   RecName: Full=adenosylhomocysteine nucleosidase {ECO:0000256|ARBA:ARBA00011974};
DE            EC=3.2.2.9 {ECO:0000256|ARBA:ARBA00011974};
GN   Name=mtnN {ECO:0000313|EMBL:ADP41014.1};
GN   OrderedLocusNames=HMPREF0733_11557 {ECO:0000313|EMBL:ADP41014.1};
OS   Rothia dentocariosa (strain ATCC 17931 / CDC X599 / XDIA).
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC   Rothia.
OX   NCBI_TaxID=762948 {ECO:0000313|EMBL:ADP41014.1, ECO:0000313|Proteomes:UP000000387};
RN   [1] {ECO:0000313|Proteomes:UP000000387}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17931 / CDC X599 / XDIA
RC   {ECO:0000313|Proteomes:UP000000387};
RA   Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A.,
RA   Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X.,
RA   Perez L., Shen H., Wang Q., Watt J., Xi L., Xin Y., Zhou J., Deng J.,
RA   Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A.,
RA   Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B.,
RA   Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M.,
RA   Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N.,
RA   Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W.,
RA   Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J.,
RA   Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L.,
RA   Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M.,
RA   Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G.,
RA   Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M.,
RA   Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L.,
RA   Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.;
RT   "The complete genome of Rothia dentocariosa ATCC 17931.";
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage
CC       pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-
CC       thioadenosine (hydrolase route): step 1/2.
CC       {ECO:0000256|ARBA:ARBA00004945}.
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DR   EMBL; CP002280; ADP41014.1; -; Genomic_DNA.
DR   RefSeq; WP_013398740.1; NC_014643.1.
DR   AlphaFoldDB; E3H0C0; -.
DR   GeneID; 29743643; -.
DR   KEGG; rdn:HMPREF0733_11557; -.
DR   eggNOG; COG0775; Bacteria.
DR   HOGENOM; CLU_031248_2_2_11; -.
DR   UniPathway; UPA00904; UER00871.
DR   Proteomes; UP000000387; Chromosome.
DR   GO; GO:0008782; F:adenosylhomocysteine nucleosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008930; F:methylthioadenosine nucleosidase activity; IEA:InterPro.
DR   GO; GO:0019509; P:L-methionine salvage from methylthioadenosine; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009164; P:nucleoside catabolic process; IEA:InterPro.
DR   CDD; cd09008; MTAN; 1.
DR   Gene3D; 3.40.50.1580; Nucleoside phosphorylase domain; 1.
DR   InterPro; IPR010049; MTA_SAH_Nsdase.
DR   InterPro; IPR000845; Nucleoside_phosphorylase_d.
DR   InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR   NCBIfam; TIGR01704; MTA_SAH-Nsdase; 1.
DR   PANTHER; PTHR46832; 5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE; 1.
DR   PANTHER; PTHR46832:SF1; 5'-METHYLTHIOADENOSINE_S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE; 1.
DR   Pfam; PF01048; PNP_UDP_1; 1.
DR   SUPFAM; SSF53167; Purine and uridine phosphorylases; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW   Glycosidase {ECO:0000313|EMBL:ADP41014.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ADP41014.1};
KW   Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167}.
FT   DOMAIN          51..287
FT                   /note="Nucleoside phosphorylase"
FT                   /evidence="ECO:0000259|Pfam:PF01048"
SQ   SEQUENCE   305 AA;  33205 MW;  40460555CD4DAA8C CRC64;
     MSEQHHSGEQ GHSEEAAQMF PTDFTPADIF NEMYADLENL NDLMMSFSNA IVIQVAMDEE
     LAPFLAATEQ AQPSFTEGVA KFYPRYLMLE EDQVPLLLVR SKIGLVNAAS AVTEAINYAT
     NCLGVISAGT AGGLAQHINV GDIVLGSNYL YTDADATIFG YERGQIPGMP VSYGDRDSDW
     EEAIEAALSA LKSAQEEGSW AVHQGRMLAG NSFVTEYNVK DTREAFDAAL STDMETTAIA
     QICSNYDVSF MAVRCISDLC GPAADQEFHL SVDVVAPRSA RYALQIAAEL WTQQELPALE
     LNLED
//