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Database: UniProt
Entry: E3H6T4_ILYPC
LinkDB: E3H6T4_ILYPC
Original site: E3H6T4_ILYPC 
ID   E3H6T4_ILYPC            Unreviewed;       317 AA.
AC   E3H6T4;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   16-JAN-2019, entry version 49.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   OrderedLocusNames=Ilyop_0666 {ECO:0000313|EMBL:ADO82453.1};
OS   Ilyobacter polytropus (strain DSM 2926 / CuHBu1).
OC   Bacteria; Fusobacteria; Fusobacteriales; Fusobacteriaceae; Ilyobacter.
OX   NCBI_TaxID=572544 {ECO:0000313|EMBL:ADO82453.1, ECO:0000313|Proteomes:UP000006875};
RN   [1] {ECO:0000313|EMBL:ADO82453.1, ECO:0000313|Proteomes:UP000006875}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 2926 / CuHBu1 {ECO:0000313|Proteomes:UP000006875};
RX   PubMed=21304735;
RA   Sikorski J., Chertkov O., Lapidus A., Nolan M., Lucas S.,
RA   Del Rio T.G., Tice H., Cheng J.F., Tapia R., Han C., Goodwin L.,
RA   Pitluck S., Liolios K., Ivanova N., Mavromatis K., Mikhailova N.,
RA   Pati A., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Brambilla E., Yasawong M., Rohde M., Pukall R.,
RA   Spring S., Goker M., Woyke T., Bristow J., Eisen J.A., Markowitz V.,
RA   Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Ilyobacter polytropus type strain
RT   (CuHbu1).";
RL   Stand. Genomic Sci. 3:304-314(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
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DR   EMBL; CP002281; ADO82453.1; -; Genomic_DNA.
DR   RefSeq; WP_013387123.1; NC_014632.1.
DR   STRING; 572544.Ilyop_0666; -.
DR   EnsemblBacteria; ADO82453; ADO82453; Ilyop_0666.
DR   KEGG; ipo:Ilyop_0666; -.
DR   eggNOG; ENOG4105D6E; Bacteria.
DR   eggNOG; COG0460; LUCA.
DR   HOGENOM; HOG000076616; -.
DR   KO; K00003; -.
DR   OMA; FEASVCG; -.
DR   OrthoDB; 1464088at2; -.
DR   BioCyc; IPOL572544:G1GOH-687-MONOMER; -.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000006875; Chromosome.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR022697; HDH_short.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF036497; HDH_short; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006875};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR036497-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579,
KW   ECO:0000313|EMBL:ADO82453.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006875};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN        7    123       NAD_binding_3. {ECO:0000259|Pfam:
FT                                PF03447}.
FT   DOMAIN      131    307       Homoserine_dh. {ECO:0000259|Pfam:
FT                                PF00742}.
FT   NP_BIND       7     12       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   ACT_SITE    198    198       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR036497-1}.
FT   BINDING      99     99       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   BINDING     183    183       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR036497-2}.
SQ   SEQUENCE   317 AA;  34592 MW;  26D4925E535BC5E4 CRC64;
     MKLGVIGLGT VGEGVLKILT LEKDRLEAMF GEKINVTKVC DLEERNFPFG KFNFTNNYKE
     ILADEEINTV VELIGGVGIA FEIAKEILGS GRNLVCANKH LIATHGKELF ALAEKNNVKF
     FFEAAVAGGI PVVTPLKEGL FPNRFERIRG ILNGTCNYML SKMEEGMSYD EALADAQEKG
     YAEADPTFDV AGIDTGHKIS VLAYLAWGEL KEFSSIPITG IDKLTKEDIE KAKAEGKRYK
     LLGEAFKEEG KLTVRVSPQL IESSELLYDV GGVYNAVEID GSYTGKTIFF GEGAGMDATA
     SAVVSDIYKV LASRSWN
//
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