ID E3H821_ILYPC Unreviewed; 1138 AA.
AC E3H821;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN OrderedLocusNames=Ilyop_1472 {ECO:0000313|EMBL:ADO83252.1};
OS Ilyobacter polytropus (strain ATCC 51220 / DSM 2926 / LMG 16218 / CuHBu1).
OC Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Fusobacteriaceae;
OC Ilyobacter.
OX NCBI_TaxID=572544 {ECO:0000313|EMBL:ADO83252.1, ECO:0000313|Proteomes:UP000006875};
RN [1] {ECO:0000313|EMBL:ADO83252.1, ECO:0000313|Proteomes:UP000006875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51220 / DSM 2926 / LMG 16218 / CuHBu1
RC {ECO:0000313|Proteomes:UP000006875};
RX PubMed=21304735; DOI=10.4056/sigs.1273360;
RA Sikorski J., Chertkov O., Lapidus A., Nolan M., Lucas S., Del Rio T.G.,
RA Tice H., Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S., Liolios K.,
RA Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A., Palaniappan K.,
RA Land M., Hauser L., Chang Y.J., Jeffries C.D., Brambilla E., Yasawong M.,
RA Rohde M., Pukall R., Spring S., Goker M., Woyke T., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Ilyobacter polytropus type strain (CuHbu1).";
RL Stand. Genomic Sci. 3:304-314(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CP002281; ADO83252.1; -; Genomic_DNA.
DR RefSeq; WP_013387919.1; NC_014632.1.
DR AlphaFoldDB; E3H821; -.
DR STRING; 572544.Ilyop_1472; -.
DR KEGG; ipo:Ilyop_1472; -.
DR eggNOG; COG0587; Bacteria.
DR HOGENOM; CLU_001600_0_0_0; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000006875; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000006875};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..73
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1138 AA; 130907 MW; DBCA1FE4D610AB2E CRC64;
MKNNFVHLHL HTEYSLLDGV GKIDEYLDRA KKLGMRSMAI TDHGNMFGAV EFYKKALSKG
IKPIVGMEAY LSEFSMEEKS GRNFHLVLLA KNETGYKNLM KLSSEAYLKG FYYRPRIDKE
ILAQHSKGII ALSACMQGEL SKRILDEESE EDLDKAVNEY VEIFGKEDFY VELQSNGIKK
QEKLNDALYT LAKKHDLKVV ATNDTHYVYY GDHTLQDILI CVQTGSKISD EKRMKIETDQ
LFLKSREQML EELGKYDRAV DNTVEIADKC NLELEFGVFK FPEYKIPTCV DSIREFLRKL
VYQGLKRRYK NDLEKDVIER VEYELDVINK MDYAGYFVVV WDFIDYAKKN RIPVGPGRGS
AAGSMVAYSL GITELDPMKY NLIFERFLNP ERISMPDIDI DICQERRQEV IDYVGEKYGK
DRVAQIITFG TMKARAAIRD VGRVMNVPLF KVDKIAKLIP PFFSLDRALK EVEELREVYE
TDSESQELIE YSKRLENTVR HASIHAAGVV ITKDPLTDDV PLYSDTKTKV VSTQYQMKEL
EELGLLKMDF LGLRNLTILQ RTVDYIREDT NEEIDLNKIP LDSLEVYRLL QKGDTLGVFQ
LESHGIRKLL MKLKPDRFED IIAVLALYRP GPLGSGMVDD FIEVKNGRAA IKYPHQSLED
VLKETYGVIL YQEQVMKIAN IMADYTLGEA DLLRRAMGKK NMAIMEENRN KFVKRAVKKG
YSEEKATEIF NLIDKFAGYG FNKSHSAAYA LVAYWTAYFK GCYPKHYYAA LMTSERNNIE
KLAVYVEDAK EHGIGVALPN INKISTRFIV DGDLVRFGMS AIKNVGETLI ERIKAEHARN
GDYTTFENFV TRGKKEGVNK KALEALILSG ALDSIPGNRR QKYESMEKAL NYATKVMKED
DIQQMNLFGE ARATIEKFQM PSVEEYKMEN LLTGEKEFLG FYFTGHPLDK YRQMLKVYRL
TEIKDIVSDM PVHIKTYGMV RNLKKVITKK SGQVMGVFDL EDYYGRIGAV VFPRDYQKMG
HYLLDGAPLY VEGVVQTDHF GGHEEKKIII RELRPLDEIG EILKFKVYIL IEEEDKPKLP
ALKKIISRHQ GDHRIYLALR EKGEKKTVEL ANKYRVTPSK YFISEVVGLL GIENIVIK
//
