ID E3HE28_ILYPC Unreviewed; 688 AA.
AC E3HE28;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN OrderedLocusNames=Ilyop_2896 {ECO:0000313|EMBL:ADO84640.1};
OS Ilyobacter polytropus (strain ATCC 51220 / DSM 2926 / LMG 16218 / CuHBu1).
OG Plasmid pILYOP02 {ECO:0000313|EMBL:ADO84640.1,
OG ECO:0000313|Proteomes:UP000006875}.
OC Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Fusobacteriaceae;
OC Ilyobacter.
OX NCBI_TaxID=572544 {ECO:0000313|EMBL:ADO84640.1, ECO:0000313|Proteomes:UP000006875};
RN [1] {ECO:0000313|EMBL:ADO84640.1, ECO:0000313|Proteomes:UP000006875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51220 / DSM 2926 / LMG 16218 / CuHBu1
RC {ECO:0000313|Proteomes:UP000006875};
RC PLASMID=pILYOP02 {ECO:0000313|Proteomes:UP000006875};
RX PubMed=21304735; DOI=10.4056/sigs.1273360;
RA Sikorski J., Chertkov O., Lapidus A., Nolan M., Lucas S., Del Rio T.G.,
RA Tice H., Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S., Liolios K.,
RA Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A., Palaniappan K.,
RA Land M., Hauser L., Chang Y.J., Jeffries C.D., Brambilla E., Yasawong M.,
RA Rohde M., Pukall R., Spring S., Goker M., Woyke T., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Ilyobacter polytropus type strain (CuHbu1).";
RL Stand. Genomic Sci. 3:304-314(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
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DR EMBL; CP002283; ADO84640.1; -; Genomic_DNA.
DR RefSeq; WP_013389292.1; NC_014634.1.
DR AlphaFoldDB; E3HE28; -.
DR KEGG; ipo:Ilyop_2896; -.
DR eggNOG; COG0550; Bacteria.
DR HOGENOM; CLU_002929_5_2_0; -.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000006875; Plasmid pILYOP02.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:ADO84640.1};
KW Plasmid {ECO:0000313|EMBL:ADO84640.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006875};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 1..135
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
SQ SEQUENCE 688 AA; 79747 MW; 5E23D3715714BEF5 CRC64;
MKLIICEKPS LALNVARALG QFQKREGYFF TNKYIVSFAF GHLFELKSVN DYFGENKRWQ
DVSLPFIPEK FEFKLKNNEG IQKQFKILQK IIKENPITEI VNCGDADREG QIIVDIIIDT
LKTNLKVTRL WLPEQTEDTI RKELKNLSPN EKYTNLAAEG YARTYLDWIL GINITRHISL
KKGTLLRAGR VMIPVVKFIY DRDLEIKNFK PEKYLQLVSE TEGIKLEVKE KFKLKDAAKA
EEKGHLLNNS QALVSDLKKE KVKKYPKKLF SLSQLQSELS KSHKINFQAS MKSIQSLYEK
GYITYPRTNT EYLSINEIPK IESIIKNYPE VNLKVKKLKS IFDDNKLESH SAIIITTKRP
KKDELKALEK TIYKTVFNRF VSNFLDEETI ISKTTLKIRV NEEIFTLKGE TIENEGFLKY
EPQKITNNLP KLNVGDIFKV DFKIVSKETQ APSKITESSL SSFLKNPFKT EKTTENEEYK
AILEGVEIGT EATRTGIVEK CIKEKYLSQK GQNFSIEPLG EDLIKTLDIL QINLYKNRTI
EFSKLLKKIS RGETSLESLI SLTKEELDIT ISKKVEIDKI NTKSYDKEII GICPKCGKNI
YQGKTKTKKI TYYCEAYKEG CKFVLWEDSK HYDNKIKITK TKAKLLLNKS RKALFKLKNK
SGKEYEAYLK LKLNGDYINF ELDSFPKK
//
