ID E3HX99_ACHXA Unreviewed; 331 AA.
AC E3HX99;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=3-hydroxybutyryl-CoA dehydrogenase 2 {ECO:0000313|EMBL:ADP17621.1};
DE EC=1.1.1.157 {ECO:0000313|EMBL:ADP17621.1};
GN Name=paaH2 {ECO:0000313|EMBL:ADP17621.1};
GN OrderedLocusNames=AXYL_04302 {ECO:0000313|EMBL:ADP17621.1};
OS Achromobacter xylosoxidans (strain A8).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Achromobacter.
OX NCBI_TaxID=762376 {ECO:0000313|EMBL:ADP17621.1, ECO:0000313|Proteomes:UP000006876};
RN [1] {ECO:0000313|EMBL:ADP17621.1, ECO:0000313|Proteomes:UP000006876}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A8 {ECO:0000313|EMBL:ADP17621.1,
RC ECO:0000313|Proteomes:UP000006876};
RX PubMed=21097610; DOI=10.1128/JB.01299-10;
RA Strnad H., Ridl J., Paces J., Kolar M., Vlcek C., Paces V.;
RT "Complete genome sequence of the haloaromatic acids-degrading bacterium
RT Achromobacter xylosoxidans A8.";
RL J. Bacteriol. 193:791-792(2011).
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
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DR EMBL; CP002287; ADP17621.1; -; Genomic_DNA.
DR AlphaFoldDB; E3HX99; -.
DR STRING; 762376.AXYL_04302; -.
DR KEGG; axy:AXYL_04302; -.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_009834_2_0_4; -.
DR Proteomes; UP000006876; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008691; F:3-hydroxybutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR PIRSF; PIRSF000105; HCDH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ADP17621.1}.
FT DOMAIN 5..190
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 195..293
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT SITE 149
FT /note="Important for catalytic activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR000105-1"
SQ SEQUENCE 331 AA; 36394 MW; 07776E1A404415D1 CRC64;
MNEKLCVIGA GRMGVGITLS YIHAGLDVTL IDIKPRTPAE QSAYFSRVRD ELRRELGILA
RLGLLDASQA DIALARVRLR TRQDAAADLR QARVVFEAVP ERLDAKRDAF LWLGAACAPD
SIIASTTSTF LVTELAELVE SPQRFLNAHW LNPAYLIPLV EVSRGPQTSE AATQGLLQVL
RLAGKKPVQC APAAGYIVPR IQALAMNEAA RMVEEGVASA EDIDTAVRLG FGLRFSVLGL
LEFIDWGGGD ILYYASRYLS DAIDPRFASP AVIARNMEQG RNGLRDGQGF YDYAGMDVNA
YKMERLAQLC KRLEVMDMLP RFDAARQPPV R
//
