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Database: UniProt
Entry: E3LDD3_CAERE
LinkDB: E3LDD3_CAERE
Original site: E3LDD3_CAERE 
ID   E3LDD3_CAERE            Unreviewed;       590 AA.
AC   E3LDD3;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   08-MAY-2019, entry version 50.
DE   SubName: Full=CRE-ACR-2 protein {ECO:0000313|EMBL:EFO82406.1};
GN   Name=Cre-acr-2 {ECO:0000313|EMBL:EFO82406.1};
GN   ORFNames=CRE_00600 {ECO:0000313|EMBL:EFO82406.1};
OS   Caenorhabditis remanei (Caenorhabditis vulgaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN   [1] {ECO:0000313|Proteomes:UP000008281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG   Caenorhabditis remanei Sequencing Consortium;
RA   Wilson R.K.;
RT   "PCAP assembly of the Caenorhabditis remanei genome.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
CC       membrane {ECO:0000256|SAAS:SAAS00569352}; Multi-pass membrane
CC       protein {ECO:0000256|SAAS:SAAS00569352}. Cell membrane
CC       {ECO:0000256|SAAS:SAAS00569391}; Multi-pass membrane protein
CC       {ECO:0000256|SAAS:SAAS00569391}.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00978283}.
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DR   EMBL; DS268407; EFO82406.1; -; Genomic_DNA.
DR   RefSeq; XP_003117808.1; XM_003117760.1.
DR   STRING; 31234.CRE00600; -.
DR   EnsemblMetazoa; CRE00600; CRE00600; WBGene00051450.
DR   GeneID; 9823876; -.
DR   CTD; 9823876; -.
DR   eggNOG; KOG3645; Eukaryota.
DR   eggNOG; ENOG410XQGR; LUCA.
DR   InParanoid; E3LDD3; -.
DR   OMA; PHVFDFV; -.
DR   OrthoDB; 381858at2759; -.
DR   Proteomes; UP000008281; Unassembled WGS sequence.
DR   GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043005; C:neuron projection; IEA:EnsemblMetazoa.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IEA:EnsemblMetazoa.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0098703; P:calcium ion import across plasma membrane; IEA:EnsemblMetazoa.
DR   GO; GO:0007274; P:neuromuscular synaptic transmission; IEA:EnsemblMetazoa.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:EnsemblMetazoa.
DR   GO; GO:0040012; P:regulation of locomotion; IEA:EnsemblMetazoa.
DR   GO; GO:0006937; P:regulation of muscle contraction; IEA:EnsemblMetazoa.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00254; NICOTINICR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   TIGRFAMs; TIGR00860; LIC; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|SAAS:SAAS00458005};
KW   Cell membrane {ECO:0000256|SAAS:SAAS00458000};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008281};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00081591};
KW   Ion channel {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00458066};
KW   Ion transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457919};
KW   Ligand-gated ion channel {ECO:0000256|SAAS:SAAS00172123};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Postsynaptic cell membrane {ECO:0000256|SAAS:SAAS00081626};
KW   Receptor {ECO:0000256|SAAS:SAAS00172128};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Synapse {ECO:0000256|SAAS:SAAS00103537};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00081549}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    590       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003173391.
FT   TRANSMEM    281    304       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    316    333       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    345    368       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    535    560       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       61    252       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   DOMAIN      287    559       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
SQ   SEQUENCE   590 AA;  67434 MW;  F590C16D32204521 CRC64;
     MNKTVRILLI LVTVFLKVQC NSAHDDEAAD VLSHANIDDF NNSSDPNRNA GEQGDTMGED
     EDRLVIDLFR EYNFLIRPVR NVSSPPVVVD FGVAMILLIN VDEKNQILQT NVWLTMKWND
     FQLAWNPAEY GNISNLHVPS DRVWLPDIVL FNNADGNYEV SFKSNVFVDH HGDVTWVPPA
     MFKSSCRIDV EWFPFDEQCC TLVFGSWTYN SEEVRLHWYN NIQAVQLHDY SYSGIWDVIG
     MRFLESEKQK VTSDVPGQLV HKPDLKENKM VFNVVIRRKT LFYTVILIIP TVLMAFLSVM
     AFYLPVDSGE KVSLTISLLL ALVVFLLLVS KILPPTSNIP LMGKYLLLAF VLNIVAVVGT
     VVIVNIYFRS ALSHKMPTWV RKVFLEFLPH LLVMKRPERI PIFNGYFVEE YCASEIFDAS
     LVMPSMTATM LPFLQVTANM KEVSSTSSGQ SSEHHENCSK WKKRLSIRMS RRRAPRARLD
     DDSEDIVDDS NGNHVDSLQE KISKEMKTTV EAIAYIAEHM KREMSLKKMR DDWKYVAMVL
     DRLILLIFFG VTLGGTLGII CSAPHVFDFV DQEAIINKLN AKYLPSDMYS
//
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