ID E3LE44_CAERE Unreviewed; 1774 AA.
AC E3LE44;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=CRE-MTM-5 protein {ECO:0000313|EMBL:EFO82341.1};
GN Name=Cre-mtm-5 {ECO:0000313|EMBL:EFO82341.1};
GN ORFNames=CRE_00256 {ECO:0000313|EMBL:EFO82341.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR EMBL; DS268407; EFO82341.1; -; Genomic_DNA.
DR RefSeq; XP_003117743.1; XM_003117695.1.
DR STRING; 31234.E3LE44; -.
DR EnsemblMetazoa; CRE00256.1; CRE00256.1; WBGene00051714.
DR eggNOG; KOG1090; Eukaryota.
DR HOGENOM; CLU_002298_1_1_1; -.
DR InParanoid; E3LE44; -.
DR OMA; KITESLW; -.
DR OrthoDB; 3195274at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR022096; SBF1/SBF2.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF109; SET DOMAIN BINDING FACTOR, ISOFORM A; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF12335; SBF2; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 14..412
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 998..1479
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT DOMAIN 1570..1620
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 1673..1773
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 1774 AA; 203093 MW; CBF072B9F66F64FC CRC64;
MRDPDKVKSG PICDTVAVIV LEESEDENAL PDVLHEVQSP HTSDTIPTSS IKKFVRPRGW
YNQSETSPSE FFYQILTTEK GARRIAYVLS TWEEDETTKN FKAVSIVLIS QNFHPKAFKE
ILLEISNDLR TPEFSSSSEL IRFLTDELVE EGSTIEIRTK TLHVELGFEL SPVSPVTGKD
VAMLFKMLGF RNVVKVIHAL LSDCRIVLAS SSLMRLSRCQ NAILSLLYPF VYVHSCVTIL
PDSLAEVLES PTPFLIGVLT EFVTSFGDEN IVVYLDNGEV HIPDHTEIFK ADDYYYESLH
QRLRDVLFTT TSQEDLAVPS EERLDVDEFI LDKKLRACFI LYFAELLYGY QYYILYTRIK
GNFEKKLTTS LTFHVGAFRG FRKLTDMMSS SLLKSVYFQT FILSRALPRR KHDLFDEISC
LKELDQLIYK QKSNSYESRK IIEQISCELI QKERYMEKCS VRKQEVFTKI YWTTGKELAP
NNNSIIHTVK PKMRSNVILQ AMLPVVNTHV EYHANQFEAY AHRIEALRNC LGDIFESKVS
FASKSLDAVK SSMRFAPLRI ELCRLLNQKS SALAVLSDKQ FDDIALLMNA ALQAECEEDK
DGVVRSLMYL SSVYSRKLTQ GVQQYMYTAL QEHKVWKNQR FWTSCFYYEV HEMLFSEMLK
QDRKITESLW CHTLRPCAME MIDTDDTDQE ELVRQENEMI QAQAKHFANL IICLLIPLTD
EFFDNEENHT AVQTEKSKWI AYTLDSILGV TGRINGLPLS RIQNYVEAHV ESLRDVYLEL
SHGDHLKKDN FDPILVCPSE FLLSDPIDCY LLTNTEESTM SLNRLENLLP ASGSLFLTNY
RVIFKGKSVD INVTNGTIVQ TLPLYSVESF KKLTSKKMIP SQLIEKGVKI EHIIAIRSSC
AATIIVAFDE DEINNLAIEK FLEVIESSSR NSFAFYNIRK DKTITDTSSH KFSTLNSAIR
GFTKKKTDPR RIRSHSSHRG SVHIQFDKIE DFDHLKKNAY IRYAVIDYPR LGLNSKNVKL
RMSAANLDYN ICPSYPGNFI VPSETNESEI AKVAKVFYSI MFNIVKILFK GFVDHRLPVV
VWMHGNGSLL IRASAFTSTD MVKKLKKVVN YRRNAPKLTG TMTGSQQTLH SKASSNEESC
SNVVAGAEIK SAEVQLNYFA KLANSSQKVV SFALPTQYAE KNSVFNDGCT LTHHNGYSSR
TANTETVTIT ANGFPVSRFH RKALYVLLEK GHAVKIPTDS NAEAIMVRSV KESELRRSLQ
KARQIYSKEF PKDAKISNLE AWNLSNWPQS VSRMIELSNA IVALMSLYNS SVAICLEAGR
SITTILSSLA QLLSDPYYRT FAGFRVLIEK EWLSFGHYFH KDAEMCSPSF LCFLDCVHQV
MQQYPSAFEF SDFYLNFMAF HSAAGYFRTF VDDCEEKRLQ SDANEFYLPD DLTTISIWEY
IKLRIRVSTS FLNEMYEPFG DVLVPSSSLS QIRMWSFLTE THLRFGSPYD IESSYHERKL
VDAECEEEDW SNLDTTEDLD KSVSFTKPPE TDSTKMNAIK ALQKSFLVEL FDASEKKTTS
NGEANGKETV HELAPFAVGA RPVQCCYCAN ILTRWSKAVH CKKCRIHIHE GCVNRNITIG
NIVHTWEAKP LENIKMPSAA IQISTPTAEK VAYSPSNTLT RESMSPPISN NIPPLCTGYL
SKRGAKLKLW VPRFFVLYRD TPKVYYYEDL DNWKNSEKPS GLIDLVEYKN CHLEQNGRRA
FMELHMKNRT YRLLSENMNE AVRWKECIEQ VIRD
//
