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Database: UniProt
Entry: E3LF96_CAERE
LinkDB: E3LF96_CAERE
Original site: E3LF96_CAERE 
ID   E3LF96_CAERE            Unreviewed;       881 AA.
AC   E3LF96;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   25-APR-2018, entry version 30.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=Cre-vha-6 {ECO:0000313|EMBL:EFO85999.1};
GN   ORFNames=CRE_01751 {ECO:0000313|EMBL:EFO85999.1};
OS   Caenorhabditis remanei (Caenorhabditis vulgaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN   [1] {ECO:0000313|Proteomes:UP000008281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG   Caenorhabditis remanei Sequencing Consortium;
RA   Wilson R.K.;
RT   "PCAP assembly of the Caenorhabditis remanei genome.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; DS268408; EFO85999.1; -; Genomic_DNA.
DR   RefSeq; XP_003117133.1; XM_003117085.1.
DR   STRING; 31234.CRE01751; -.
DR   EnsemblMetazoa; CRE01751; CRE01751; WBGene00053565.
DR   GeneID; 9822184; -.
DR   CTD; 9822184; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; E3LF96; -.
DR   OMA; MFLQPEA; -.
DR   OrthoDB; EOG091G01BI; -.
DR   Proteomes; UP000008281; Unassembled WGS sequence.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:EnsemblMetazoa.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IEA:EnsemblMetazoa.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0002119; P:nematode larval development; IEA:EnsemblMetazoa.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008281};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    412    437       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    457    475       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    557    584       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    596    627       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    639    659       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    709    730       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    810    834       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    121       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   881 AA;  100750 MW;  41FF185AD56E894C CRC64;
     MGSIYRSEHM KLCQIFFQSE SAYQCVAELG ELGLAQFIDL NEEQNSYQRK FVNEVRRCEE
     MDRKITFVEE EIKKDEVAIP DYDDHIPAPQ PKHMGEMEAN LEKLEEELVQ INKNTKVLKT
     NHIQLLEMKA VLEHVTSLLD HQSKREAAMS ISEAARGEAG PLSFGLKQEF DKPVRDENEL
     KFVTGVIKRN KSIAFERFLW RLSRAKVFAK FVEIKEKTDV FSHDYEDKCV FILFFSGEQL
     RSKVKKICDG FQAKCYTVPE NPAERTKLLN NIKLQANDMK AVIEKTLEYR TKCISAAAGN
     LRKWGIMLLK LKSIFHTLNM FSVDVTQKCL IAECWVPEAD IVQVKNSLHM GTIHSGSTVP
     AILNEMETEK YPPTYFKLNK FTQGFQNIVD AYGIASYREV NPAPWTIISF PFLFAVMFGD
     AGHGIIMLIA ASAFVIFEKK LISMKIKDEI FNTFFGGRYV VLLMGMFAIY TGFIYNDFYS
     KSINMFGSSW QNPYPKSLLE QMDAQGVESG NELSLTFAPE DAFNHAYGPY PFGVDPVWNL
     AINRLNFLNP MKMKTSILLG ISQMAFGIML SLMNHMLVFS FFLYDLINNF SGNRSVVDIV
     FVFIPQCLFL GCIFVYLCLQ VIMKWIFFYV KPAMVFGKFY PGPNCAPSLL IGLINMFMVK
     SRDVRFGKNP NIRKITAMNF TLNGKPVTYT DYDQCYLQQW YPNQSLVEVI LLLIAVISVP
     VMLLVKPFYI RWRHGRGLPV DLGHGPDDHG EFNFGDIMVH QAIHTIEFVL GCVSHTASYL
     RLWALSLAHA QLSDVLWTMV LRMSLTMGGW GGSAAVTIIF YFIFSILSVC ILILMEGLSA
     FLHAIRLHWV EFQSKFYGGT GIQFEPFSFT KIIRVYEGLD Q
//
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