ID E3LF96_CAERE Unreviewed; 881 AA.
AC E3LF96;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN Name=Cre-vha-6 {ECO:0000313|EMBL:EFO85999.1};
GN ORFNames=CRE_01751 {ECO:0000313|EMBL:EFO85999.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR EMBL; DS268408; EFO85999.1; -; Genomic_DNA.
DR RefSeq; XP_003117133.1; XM_003117085.1.
DR AlphaFoldDB; E3LF96; -.
DR STRING; 31234.E3LF96; -.
DR EnsemblMetazoa; CRE01751.1; CRE01751.1; WBGene00053565.
DR eggNOG; KOG2189; Eukaryota.
DR HOGENOM; CLU_005230_0_0_1; -.
DR InParanoid; E3LF96; -.
DR OMA; AIHTVEY; -.
DR OrthoDB; 1967517at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; IEA:EnsemblMetazoa.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR GO; GO:0002119; P:nematode larval development; IEA:EnsemblMetazoa.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF58; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 3; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 2.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 412..437
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 457..475
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 557..584
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 596..627
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 639..659
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 709..730
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 810..834
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 94..121
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 881 AA; 100750 MW; 41FF185AD56E894C CRC64;
MGSIYRSEHM KLCQIFFQSE SAYQCVAELG ELGLAQFIDL NEEQNSYQRK FVNEVRRCEE
MDRKITFVEE EIKKDEVAIP DYDDHIPAPQ PKHMGEMEAN LEKLEEELVQ INKNTKVLKT
NHIQLLEMKA VLEHVTSLLD HQSKREAAMS ISEAARGEAG PLSFGLKQEF DKPVRDENEL
KFVTGVIKRN KSIAFERFLW RLSRAKVFAK FVEIKEKTDV FSHDYEDKCV FILFFSGEQL
RSKVKKICDG FQAKCYTVPE NPAERTKLLN NIKLQANDMK AVIEKTLEYR TKCISAAAGN
LRKWGIMLLK LKSIFHTLNM FSVDVTQKCL IAECWVPEAD IVQVKNSLHM GTIHSGSTVP
AILNEMETEK YPPTYFKLNK FTQGFQNIVD AYGIASYREV NPAPWTIISF PFLFAVMFGD
AGHGIIMLIA ASAFVIFEKK LISMKIKDEI FNTFFGGRYV VLLMGMFAIY TGFIYNDFYS
KSINMFGSSW QNPYPKSLLE QMDAQGVESG NELSLTFAPE DAFNHAYGPY PFGVDPVWNL
AINRLNFLNP MKMKTSILLG ISQMAFGIML SLMNHMLVFS FFLYDLINNF SGNRSVVDIV
FVFIPQCLFL GCIFVYLCLQ VIMKWIFFYV KPAMVFGKFY PGPNCAPSLL IGLINMFMVK
SRDVRFGKNP NIRKITAMNF TLNGKPVTYT DYDQCYLQQW YPNQSLVEVI LLLIAVISVP
VMLLVKPFYI RWRHGRGLPV DLGHGPDDHG EFNFGDIMVH QAIHTIEFVL GCVSHTASYL
RLWALSLAHA QLSDVLWTMV LRMSLTMGGW GGSAAVTIIF YFIFSILSVC ILILMEGLSA
FLHAIRLHWV EFQSKFYGGT GIQFEPFSFT KIIRVYEGLD Q
//
