ID E3LGD4_CAERE Unreviewed; 786 AA.
AC E3LGD4;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=GPI ethanolamine phosphate transferase 2 {ECO:0000256|ARBA:ARBA00020830};
GN ORFNames=CRE_01547 {ECO:0000313|EMBL:EFO86364.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
CC {ECO:0000256|ARBA:ARBA00005315}.
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DR EMBL; DS268408; EFO86364.1; -; Genomic_DNA.
DR RefSeq; XP_003117498.1; XM_003117450.1.
DR AlphaFoldDB; E3LGD4; -.
DR STRING; 31234.E3LGD4; -.
DR EnsemblMetazoa; CRE01547.1; CRE01547.1; WBGene00053941.
DR eggNOG; KOG2125; Eukaryota.
DR HOGENOM; CLU_004770_2_0_1; -.
DR InParanoid; E3LGD4; -.
DR OMA; NWVYQFK; -.
DR OrthoDB; 5479199at2759; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051377; F:mannose-ethanolamine phosphotransferase activity; IEA:InterPro.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd16024; GPI_EPT_2; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 2.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR037674; PIG-G_N.
DR InterPro; IPR039527; PIGG/GPI7.
DR InterPro; IPR045687; PIGG/GPI7_C.
DR PANTHER; PTHR23072:SF0; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2; 1.
DR PANTHER; PTHR23072; PHOSPHATIDYLINOSITOL GLYCAN-RELATED; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR Pfam; PF19316; PIGO_PIGG; 2.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 417..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 469..487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 585..610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 616..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..667
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 739..756
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 421..514
FT /note="GPI ethanolamine phosphate transferase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19316"
FT DOMAIN 671..779
FT /note="GPI ethanolamine phosphate transferase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19316"
FT REGION 35..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 786 AA; 90242 MW; 32F99297E921F3DC CRC64;
MKNLIKFLFQ TSRLLVVVAC ILLVYSFVAL EGRGKEDGET DGDDRKTNRR TTENEKEKKD
RIPLQDLNFQ FPETPRLVFM VIDAFRLSFL TSPESPMTFT KSSIANNSAL LFDAYARMPT
VTLPRITAYI TGTLPSFGTI LTNLATDEIK IDNWISRIHA LKKRIHFFGD DTWIRLLPGK
FKKYDGVTSF YVNDYTEVDQ NVTRHLRKEF SGFRKWDVLI LHYLGLDHIG HSLGGNSPKI
PEKLKEMDEV IVRIHEFLRN SSSDSRENYL IVCGDHGMTA AGSHGGASPE ETRVPVVMWK
IGRQTNEKMV KNTEKPPKIE QIDVSATIFD LFGLEMPSES YGISLASWFR DENFEEENLK
KQHEHFKNII EEKHLSISDI CDENCDYTDK FLQKSLKKWF KTVQEELIGT STEMPNISMF
ISFALLLQVS ATVLSANAWF FRTPQLNLSI FLVNIMCFAS SLIEEEHEIW FYLGSTVVAI
RAIRWLRNRE QKELKPIIAL AVLHRIAYGY MQSTRRRWSM DQSLLPESLF SEVFDRNVTD
FNTFLKFDAI LVMIGSFIYW WIYIKKNHSL IFLPMLSQYL RYMEFAPIGI FNISAQIHIL
IQLCVVPIGI ITGTMLFGFL PLILAIVPVS QVLLALFTYR IGHLSAKLQF GDVENLIFCM
ASFFYFFCND NFQFQGNSNS LSTLSLTSAY VGLLDYYPIL VGAQLIVYTF AGPVLYMAGR
TSFVSTKSPA TSHWLQLHFS FRISALATSL ICLYIFQNHL FVWSVYSPKV VYDIAHVIVF
GVISAF
//
