ID E3LM22_CAERE Unreviewed; 1181 AA.
AC E3LM22;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN Name=Cre-msh-6 {ECO:0000313|EMBL:EFP03292.1};
GN ORFNames=CRE_28049 {ECO:0000313|EMBL:EFP03292.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; DS268411; EFP03292.1; -; Genomic_DNA.
DR RefSeq; XP_003115157.1; XM_003115109.1.
DR AlphaFoldDB; E3LM22; -.
DR STRING; 31234.E3LM22; -.
DR EnsemblMetazoa; CRE28049.1; CRE28049.1; WBGene00056429.
DR eggNOG; KOG0217; Eukaryota.
DR HOGENOM; CLU_002472_1_3_1; -.
DR InParanoid; E3LM22; -.
DR OMA; TPMMAQY; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03286; ABC_MSH6_euk; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281}.
FT DOMAIN 1031..1047
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..105
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1181 AA; 133291 MW; BD96FDAE15B29C75 CRC64;
MSKRQSSLMS FFTKTPKSDK PDEKGETKES KKDEDKKVLK RTNSQTVSSP VKIIKNTPKR
ARVVVSSSSE GEDDDKDEDF EMNEDEAANE STDGSEVDEN ASDDCEVTYE STPQTTPKNT
PKRAKKMTKR LVDTPKSVKS SGLSNVRKVI PDIDEVSMVA VKEKMNKIME GGGEKRKNVE
KGGSKKKQEE EPAERFDHES LDWLKPDKIR DGCKRPMSDP EYDPKTLWVP PEFHQKQTPG
HRQWWTIKSQ HFDTIILFKV GKFYETYHMD AVEVVRALNI AFMRGSYAHA GFPEHAASKF
ADQLMNHGYK VARVEQTETP QMLEERNQKT KAKDKVVRRE VCRVTSNGTR TYGVLDGVDL
GSAASTLDPT AKHLLAIKEF HNAETGKSSY GICMIDTTTA HIRIGQFDDD DYRSKLRTLL
ANVIVVQTLV ERNTISASTK SIINGILFSV PIEHLLAKKQ FMTSDDVVRL VSNDDYFGSD
VSGWPDVLKS MLDESSVLPK PSSDWNLALS AFGAIVWYLR DSLIDVDMLS MRNVTFYDSK
TSKTEKQSSK DKKIDWTGKN LILDGTALEN LNIVPNGRDS HLTSLYYVIN KCSTPFGRRL
LRSWLLQPTC DPKKLRLRQE AVKWMTSSDA TSFVNVATAT LKKIPDLDRL LQKIHTIGLK
YRAEKHPDSR AIFFDTIKTN QKKIGELLSA IDGFKLCNQL RKEYLKVQKD GEGCELLDEL
LGNEQQMEEV DENIYFFEKM FDRTTAQKDG KIVPNEGCDE EYDQATARVK EALGELNAYK
DTIAKKYSCA IKFVDSGKVK YLLEMPENAK VSSSFELKSR RKGFIRYSTP DSEELVAALD
TAEKEKSKLG DDATRRVFEQ FGHKNPVWLE TVRLVSNFDV LTSLATFSNS CPFDMCMPEF
DFDSTKPYLV VEKGVHPCLA LQSRNEVTQT TSFIANSTMM GEKEAAVMLL TGPNMGGKST
LMRQTAVLAI LAHIVIVFQG CKVPAFSMRL TPIDRIFTRI GANDRIMCGE STFFIELKET
DIMLKNATKH SLLLVDELGR GTSTFDGTAI ASAVLQKIAD DIICRTFFST HYHSICDSFT
NHENVRLAHM KCVVDKENNE DPTMEDVTFL YELESGICPK SYGFYAAKLA GIDHQVVRNA
YAESNKFASN LIIDPKIRHL VECARNESFD VSKLREMIEA I
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