ID   E3LP94_CAERE            Unreviewed;       686 AA.
AC   E3LP94;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE            EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN   Name=Cre-gcy-34 {ECO:0000313|EMBL:EFP05430.1};
GN   ORFNames=CRE_27550 {ECO:0000313|EMBL:EFP05430.1};
OS   Caenorhabditis remanei (Caenorhabditis vulgaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN   [1] {ECO:0000313|Proteomes:UP000008281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG   Caenorhabditis remanei Sequencing Consortium;
RA   Wilson R.K.;
RT   "PCAP assembly of the Caenorhabditis remanei genome.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001436};
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC         Evidence={ECO:0000256|ARBA:ARBA00001971};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS268412; EFP05430.1; -; Genomic_DNA.
DR   RefSeq; XP_003114092.1; XM_003114044.1.
DR   AlphaFoldDB; E3LP94; -.
DR   STRING; 31234.E3LP94; -.
DR   EnsemblMetazoa; CRE27550.1; CRE27550.1; WBGene00052783.
DR   eggNOG; KOG4171; Eukaryota.
DR   HOGENOM; CLU_011614_4_0_1; -.
DR   InParanoid; E3LP94; -.
DR   OMA; YEATVMF; -.
DR   OrthoDB; 2898719at2759; -.
DR   Proteomes; UP000008281; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007635; P:chemosensory behavior; IEA:EnsemblMetazoa.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0050913; P:sensory perception of bitter taste; IEA:EnsemblMetazoa.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 6.10.250.780; -; 1.
DR   Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR   Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR038158; H-NOX_domain_sf.
DR   InterPro; IPR011644; Heme_NO-bd.
DR   InterPro; IPR011645; HNOB_dom_associated.
DR   InterPro; IPR042463; HNOB_dom_associated_sf.
DR   InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR   PANTHER; PTHR45655:SF12; SOLUBLE GUANYLATE CYCLASE GCY-34; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF07700; HNOB; 1.
DR   Pfam; PF07701; HNOBA; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008281}.
FT   DOMAIN          455..583
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   686 AA;  78216 MW;  AA8B721B354B3EEF CRC64;
     MFGFIHESIR QLVIRKYGED TWLQVLERSG FENGKENIVN HYYSDTDTYV LVDSVSIVIK
     VTKDQVWEMY GGFLITYSME IGWDELVRSM SPNLKGFLDN LDSLHYFIDH VVYKANLRGP
     SFRCEENPDG TLMLHYFTGR PGLYHIVKGV VKEVAKLVFN LDITLSVQGR TQRSVHMNNG
     ERVEEHVIFL IKNVGENRRD SEASTVSLMT SAAPDFGEIV DDNLRMSLQD FSKALPYHFV
     LDESCKLVQC GDELYNHIPN ELLKPGTPIL RIFEINRPQI PLDFENICNF INAVFVLQVK
     TSPLKKKHMD ALTKEEQEQE VEAMEAENTS NELTQGCHLK LKGQMMMLAT KKHIIYLCSP
     YVTSINELMQ FGMRLTAMPL HDATRDLILL NQQRLTDVEV NLQLEANNEQ LETMTRELEL
     ERKKTDSILK DMLPRKIAKQ LLSGEHIEPC EYETTVMFCD LPAFQQIIPV CQPKNIVKLL
     NEVFFKLDRI VVLRGVYKVE TVSDSYMTVS GIPDYTNEHA ETMCHVALGM MWEARSVMDP
     VNNTPFLLRI GLHSGTIIAG VVGTKMPRYC LFGETVTLAS QMESLGLAGK IQCSKWTYTQ
     AMETGRFEFA PRGRITVKGR GDVETYFLTR SLKKSIWEIT DHERDVNVNS IEGYEELETS
     IESAQAARND NTTKANQNNS AACTIA
//