ID E3LQH7_CAERE Unreviewed; 1259 AA.
AC E3LQH7;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN Name=Cre-clh-3 {ECO:0000313|EMBL:EFP07819.1};
GN ORFNames=CRE_26157 {ECO:0000313|EMBL:EFP07819.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
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DR EMBL; DS268413; EFP07819.1; -; Genomic_DNA.
DR RefSeq; XP_003113907.1; XM_003113859.1.
DR AlphaFoldDB; E3LQH7; -.
DR STRING; 31234.E3LQH7; -.
DR EnsemblMetazoa; CRE26157.1; CRE26157.1; WBGene00054297.
DR eggNOG; KOG0476; Eukaryota.
DR HOGENOM; CLU_006904_1_1_1; -.
DR InParanoid; E3LQH7; -.
DR OMA; IFRILRM; -.
DR OrthoDB; 1194at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd03683; ClC_1_like; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 2.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45720; CHLORIDE CHANNEL PROTEIN 2; 1.
DR PANTHER; PTHR45720:SF10; CHLORIDE CHANNEL PROTEIN 2; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 29..51
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 57..79
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 91..109
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 277..299
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 319..342
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 428..451
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 510..530
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 551..568
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 640..659
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 666..686
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 706..729
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 736..756
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 792..851
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 860..894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 860..885
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1259 AA; 139707 MW; E50E5665E560A9FA CRC64;
MGSVVRFMDN LKQIEGYVKY VKMNQNVNML MIIFFTLAVK VSGLLTIFVP SNITTRMAVI
VSSTLITMFL LGSLLLYEYW IGGRHNRKSR YVVVLICNII ALWIFRFVTN GMPPNLSTMI
ALSAPSMVVF YYFSWNLIEW SVYINEIAMI LPRPLMPSRT PLAKIEWQSL LPLPPEKCAK
PSEENNEEIE IVRLAAGKEY DLQPGSHLGV YKTVRGVPID EDCKSMGIGT NILSKIEKNK
TSDGLTIPLT HNDQTKSSRW CSSESFKTFF RTVIRDWIFL ALLGFIMAAL SFGMDYAILN
LQNGQMRLYD IVKLFHWSLG YLVWVGYVVG LILLSAVCAH YIAPQAIGSG IPEMKTILRG
VILKEYLSIR TLVSKMIGLT LSLGSGLPMG KEGPFVHVAS VVASQLTRLV HGSNVGIYEN
ESRSGEMLAA GCAVGVACTF SAPIGGVLFS IEVTSVYFAV RNYWRGFFAA TCSATIFRIL
RMFSASAAVT VEAHYQTNFP PQNVFLPQEL PVFALVGLIC GLAGSLFVYL HRRTVLFLRR
NSLAKMIFQK YWLLYPIFIA FFISSLSWPS GLGKLMGGQE RFSHTMKEFF VNCAWTASPN
NSYACAPPVN MTPVSGDNFD IRHWTGQGED TTIPAPYSPF VTLSIFQFVY FFLAILASTL
PVPSGIFMPV FVLGAAFGRL VGEGVFTLYP DGYESGDVMF FIRPGVYAVV GAAAFCGAVT
HTVSVAVIVF EITGQLCHLL PVMIAVLIAN AVASWLQPSI YDSIIRIKNL PYLPDIPHTT
SLYHQMLIEQ FMISPVVFIA KDSTVGDVRR ALQTKTRIRA FPLVENLDSL ALVGSISRGQ
LQRYVDSHIG TKARFAEATR RVKQRLEDEE SERRRKEESK SDETADSLAS KGAGERRASR
FLVVPVAKNG SQVTKNENLS GLSDENARKI LTVEEKKALF DAVSLKVPKG EMNGRTVTTG
HIESHHTIGG EKKMNSKYAF HFSDIFRSIT HLSFGRQNIP KKNNQNEFDL YGGERAEWEE
SVLETKLDLS QLDIDSTPFQ LSEYTSLFKA HSLFSLLGLN RAYVTKKGQL IGVVALKELR
FAMEYLQAGK EPTPGISIFT DASADQTTFE KSGRIESGMD SQNPTFLTDN GEEDASDDYI
QVIQLVDLKK TFNFQPPLEV VRRGALTPNQ LSELNRVENV RLVPDSPNFE VSSPSTSSSC
VSIDLSPLDT TYSDNGSVGG LVLNVPSLPS RARSAAELNG QNSHVQINLP DNAVHDEKF
//
