UniProt: E3LSL8

Database: UniProt
Entry: E3LSL8_CAERE

LinkDB:  E3LSL8_CAERE 
Original site:  E3LSL8_CAERE

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Ontology (8)   
   GO (8)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (4)   
   EMBL (4)   
Protein domain (26)   
   InterPro (12)   
   Pfam (5)   
   PROSITE (5)   
   SMART (4)   
Literature (2)   
   PubMed (2)   
All databases (44)   

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ID   E3LSL8_CAERE            Unreviewed;       794 AA.
AC   E3LSL8;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   27-MAR-2024, entry version 77.
DE   RecName: Full=Diacylglycerol kinase {ECO:0000256|RuleBase:RU361128};
DE            Short=DAG kinase {ECO:0000256|RuleBase:RU361128};
DE            EC=2.7.1.107 {ECO:0000256|RuleBase:RU361128};
GN   Name=Cre-dgk-3 {ECO:0000313|EMBL:EFP09339.1};
GN   ORFNames=CRE_25613 {ECO:0000313|EMBL:EFP09339.1}, FL81_13374
GN   {ECO:0000313|EMBL:POM40656.1}, FL82_20456
GN   {ECO:0000313|EMBL:OZF75302.1}, GCK72_009370
GN   {ECO:0000313|EMBL:KAF1761116.1};
OS   Caenorhabditis remanei (Caenorhabditis vulgaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN   [1] {ECO:0000313|Proteomes:UP000008281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG   Caenorhabditis remanei Sequencing Consortium;
RA   Wilson R.K.;
RT   "PCAP assembly of the Caenorhabditis remanei genome.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EFP09339.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB4641 {ECO:0000313|EMBL:EFP09339.1};
RG   The Caenorhabditis remanei Sequencing Consortium;
RA   Wilson R.K.;
RT   "PCAP assembly of the Caenorhabditis remanei genome.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:POM40656.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PX356 {ECO:0000313|EMBL:POM40656.1};
RX   PubMed=26114425; DOI=10.1371/journal.pgen.1005323;
RA   Fierst J.L., Willis J.H., Thomas C.G., Wang W., Reynolds R.M.,
RA   Ahearne T.E., Cutter A.D., Phillips P.C.;
RT   "Reproductive Mode and the Evolution of Genome Size and Structure in
RT   Caenorhabditis Nematodes.";
RL   PLoS Genet. 11:e1005323-e1005323(2015).
RN   [4] {ECO:0000313|EMBL:POM40656.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PX356 {ECO:0000313|EMBL:POM40656.1};
RX   PubMed=26394399; DOI=10.1371/journal.pgen.1005497;
RA   Fierst J.L., Willis J.H., Thomas C.G., Wang W., Reynolds R.M.,
RA   Ahearne T.E., Cutter A.D., Phillips P.C.;
RT   "Correction: Reproductive Mode and the Evolution of Genome Size and
RT   Structure in Caenorhabditis Nematodes.";
RL   PLoS Genet. 11:e1005497-e1005497(2015).
RN   [5] {ECO:0000313|EMBL:OZF75302.1, ECO:0000313|Proteomes:UP000216624}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PX439 {ECO:0000313|EMBL:OZF75302.1,
RC   ECO:0000313|Proteomes:UP000216624};
RA   de Groot N.N.;
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:POM40656.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PX356 {ECO:0000313|EMBL:POM40656.1};
RA   Banno H., Chua N.-H.;
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:KAF1761116.1, ECO:0000313|Proteomes:UP000483820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PX506 {ECO:0000313|EMBL:KAF1761116.1,
RC   ECO:0000313|Proteomes:UP000483820};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:KAF1761116.1};
RA   Teterina A.A., Willis J.H., Phillips P.C.;
RT   "Chromosome-level assembly of the Caenorhabditis remanei genome.";
RL   Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-
CC         phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608,
CC         ChEBI:CHEBI:456216; EC=2.7.1.107;
CC         Evidence={ECO:0000256|ARBA:ARBA00001383,
CC         ECO:0000256|RuleBase:RU361128};
CC   -!- SIMILARITY: Belongs to the eukaryotic diacylglycerol kinase family.
CC       {ECO:0000256|ARBA:ARBA00009280, ECO:0000256|RuleBase:RU361128}.
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DR   EMBL; DS268414; EFP09339.1; -; Genomic_DNA.
DR   EMBL; WUAV01000003; KAF1761116.1; -; Genomic_DNA.
DR   EMBL; NMWX01000910; OZF75302.1; -; Genomic_DNA.
DR   EMBL; LFJK02000063; POM40656.1; -; Genomic_DNA.
DR   RefSeq; XP_003113085.1; XM_003113037.1.
DR   AlphaFoldDB; E3LSL8; -.
DR   STRING; 31234.E3LSL8; -.
DR   EnsemblMetazoa; CRE25613.1; CRE25613.1; WBGene00055153.
DR   GeneID; 9818528; -.
DR   KEGG; crq:GCK72_009370; -.
DR   CTD; 9818528; -.
DR   eggNOG; KOG1169; Eukaryota.
DR   HOGENOM; CLU_003770_1_0_1; -.
DR   OMA; QTHKSFP; -.
DR   OrthoDB; 4642163at2759; -.
DR   Proteomes; UP000008281; Unassembled WGS sequence.
DR   Proteomes; UP000216624; Unassembled WGS sequence.
DR   Proteomes; UP000483820; Chromosome iii.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004143; F:ATP-dependent diacylglycerol kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0042048; P:olfactory behavior; IEA:EnsemblMetazoa.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:EnsemblMetazoa.
DR   GO; GO:0043052; P:thermotaxis; IEA:EnsemblMetazoa.
DR   CDD; cd20851; C1_DGK_typeI_like_rpt2; 1.
DR   CDD; cd20799; C1_DGK_typeI_rpt1; 1.
DR   CDD; cd00051; EFh; 1.
DR   Gene3D; 2.60.200.40; -; 1.
DR   Gene3D; 3.30.60.20; -; 2.
DR   Gene3D; 1.10.238.110; Diacylglycerol kinase alpha; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   InterPro; IPR017438; ATP-NAD_kinase_N.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR029477; DAG_kinase_typeI_N.
DR   InterPro; IPR037607; DGK.
DR   InterPro; IPR038199; DGK_typeI_N_sf.
DR   InterPro; IPR000756; Diacylglycerol_kin_accessory.
DR   InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   PANTHER; PTHR11255; DIACYLGLYCEROL KINASE; 1.
DR   PANTHER; PTHR11255:SF48; DIACYLGLYCEROL KINASE 1; 1.
DR   Pfam; PF00130; C1_1; 2.
DR   Pfam; PF14513; DAG_kinase_N; 1.
DR   Pfam; PF00609; DAGK_acc; 1.
DR   Pfam; PF00781; DAGK_cat; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   SMART; SM00109; C1; 2.
DR   SMART; SM00045; DAGKa; 1.
DR   SMART; SM00046; DAGKc; 1.
DR   SMART; SM00054; EFh; 2.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 2.
DR   SUPFAM; SSF47473; EF-hand; 2.
DR   SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR   PROSITE; PS50146; DAGK; 1.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 2.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361128};
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU361128};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU361128};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361128};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          170..205
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          215..250
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          265..316
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   DOMAIN          329..375
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   DOMAIN          423..558
FT                   /note="DAGKc"
FT                   /evidence="ECO:0000259|PROSITE:PS50146"
SQ   SEQUENCE   794 AA;  89221 MW;  70AA178A4BF40FE6 CRC64;
     MLLSPEQFSR LSEYAAYSRR KLKDMLSDFQ QDGKFYSYLS VDGQTINIDG FRAFLIDYFG
     ADLPSDLVDQ LFLSFSKPPI KERRTSLFED AISTVRAKFT DTLSGRMTGL NIAGGSGQQT
     DRSTGSEPQA LVCIPEDDVM GPKAATNESQ EPRIPLKPLI CTLSLLEADT PENKLDVVFH
     VYDSDGNGFL DKSEIDGIIE QMMNVARYQQ WDTIELEQII RQMMVDIDYD NDGIVSFDEW
     RRGGLTNIPL LVLLGFDTEM KEDGSHVWRL RHFTKPTYCN ACCSILVGWG GKQGLSCSLC
     KYTVHERCVR SAATNCIRTY SSRQQDKLYH HWQDANATAK CVKCKATVGV FQGKGCRWCH
     NYVHHRCMSA LAQECDLGAL VHHILPPTHI FPAFLERKTS TSLKNHNFGS HSASLLQAIS
     PSNDCRPLLV LVNPKSGGKQ GVKILQKFEY LLNPRQVYDL SKTGPEPGLQ LFSTLKNCNI
     LVCGGDGTIG WVLESMDKMT FPHGRPPVAV LPLGTGNDLA RCLRWGGGYE NENLHKILEQ
     IEKSSLIDMD RWQIKIEITE NKNTRRASEK GDSPPYSIIN NYFSIGVDAS IAHRFHVMRE
     KFPEKFNSRM RNKLWYFELG TSETLSSSCK NLHEQIDILC DGESIDLGQD ASLEGIALLN
     IPSIYGGSNL WGRSRKSKSR MGLFPMKNAE KMQLQTRVQD IGDGLIELVG LESAMQMGQI
     KAGVRGARRL SQCSTVVIQT HKSFPMQIDG EPWMQPPCII QITHKNQAKM LVAAAPRKRS
     SWMLLKRQST NDDN
//

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