ID E3LZ55_CAERE Unreviewed; 3848 AA.
AC E3LZ55;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=GATOR2 complex protein WDR24 {ECO:0000256|ARBA:ARBA00040269};
GN ORFNames=CRE_04572 {ECO:0000313|EMBL:EFO86612.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the WD repeat WDR24 family.
CC {ECO:0000256|ARBA:ARBA00008134}.
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DR EMBL; DS268419; EFO86612.1; -; Genomic_DNA.
DR RefSeq; XP_003110780.1; XM_003110732.1.
DR STRING; 31234.E3LZ55; -.
DR EnsemblMetazoa; CRE04572.1; CRE04572.1; WBGene00055696.
DR eggNOG; KOG0269; Eukaryota.
DR HOGENOM; CLU_224396_0_0_1; -.
DR InParanoid; E3LZ55; -.
DR OMA; CLDWHAT; -.
DR OrthoDB; 119005at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0032008; P:positive regulation of TOR signaling; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR037590; WDR24.
DR InterPro; IPR049566; WDR59_RTC1-like_RING_Znf.
DR PANTHER; PTHR46200; GATOR COMPLEX PROTEIN WDR24; 1.
DR PANTHER; PTHR46200:SF1; GATOR COMPLEX PROTEIN WDR24; 1.
DR Pfam; PF00400; WD40; 2.
DR Pfam; PF17120; zf-RING_16; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 785..834
FT /note="WDR59/RTC1-like RING zinc finger"
FT /evidence="ECO:0000259|Pfam:PF17120"
FT REGION 556..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 936..963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1031..1079
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1265..1284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1312..1346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1399..1478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1583..1610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1640..1726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2396..2416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2861..2926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3669..3708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 481..520
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2941..2968
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 567..584
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1076
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1321..1336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1399..1421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1439..1464
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1642..1657
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2870..2891
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2910..2926
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3681..3699
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3848 AA; 447906 MW; EB719B18EDD6D6B5 CRC64;
MQEPSPGNVQ KKASSEILFA DYGKNSTDGE DPTPENKRVI DLYDPVDAMS LNREKDRVVV
SGIRGVLQII KVQRNKDSDE IETPSIVKDL DMRVYRKGKI NILYSAQNVK WNQLYDQYIA
TTSSNGSIVC WNVSRKNKSV FKAHERSATC LDWHATAPYI LVSGSRDCTV KSYDMRVKDN
HQLTFSDRNC ESIRDVAMCK APGFDDYFFT GDDGGVLRLW DLRQTRRWIF QKVAHRSFVS
TLSLNPHNRQ LLATGGGRDK MVKIWEWSGA ELNRVSVVET TAPLGRVAWR PDKPYHLATC
ASVNETTVHV WDVRRPYLPY VTYDEHRDSV TDACWPTNDF DVFLTCGKDG LVVLHNIDSG
HAPISYACDV AFDVTPDGTM GVAVNSEIHA KNDAELELNA IPLKGKKIIR QIPYESFNKP
IKSLVCFGVP ESLTHSLPPT IFYKIAEKYI IGGVEIIQLC ETNSKTARKN GLEHVAQTWR
LVEALCEQAK IQEEYDRLSV EEKERIIRAW AVRKKELAEE GRRWLANLND HYRDDVKKQV
TQRLENTQHV TAFLKFSSSS GSEASDNEKV GDTDNKRNEV DRMAPNFDRL LSKQKKRKKK
NAAPIDFYFG AGEANFKGGK REHLHYNEFM GLRAEAYELR DEEKERRFFC KARKQPTNAQ
EYEEFLMQDS EADYQAWSPM LEIYRLLLYH AEQGDMQTCA TVSMVCGKKL LDAVDPYTVN
GWIKCYMEML DRLELFLVTA KIRKYCTLDS ISSVSRENTT IQLAHADCDA LIVNGRCTKC
EVLAQADCTV CRFAIVGMTY QCNLCGHCMH ADHAYEWFQK SNSCAFRGCP CPCGGNTWPD
GIRTFIGNDE VKKGHRKFNH LEQQVEPISN RVDVSRLDTD SEESPDEDLE WSPANNILKN
KYGEVPCKDW NTEWAQQLLQ MCSLRNMKPH EIAALEEEKE REREKSETED ENPHIWSPKT
QKELDESDIR RTLMYRLEDD DREKKEVIES TPTEEETYDV DREDFVWDFL ASSSSEDEIV
ETESVVDQWP RLEQIPEEDE DFIEDEDGNE IRKVLPKEKE KKKPKLKPKP KKKGNEVARK
RFVEKISNRS RGPEERPLVL FDEEMASMKE DKWDMLECDD YIHSIGHIGV PPQQFSAIYE
RKRRDNERVT SPTLTFAIRN HVKTKSGLYC STSASETDVD EELGFEKRCC ESRQNGTDGI
VTEREGTVKP TLSYGERALK ILSMNKKELK KLKAKKEKRR IDIIYGNIFG KSNQQTAELS
PDEFIVSSSS DDSDSTNSSK STTSVFSESS ASELFIPVPE ATPLNVNEGY KAESEDGFSS
ESTSHEQLSA EPTLRLPTPQ ATGDLYLKPE SPKRVVVQKM KKYKKVRSAL SYSVEDVGRY
PDEHADNYFI CINGAVPSPT QSRLSSPQVS PMQSIPSSRF SSELDPPPAP LTSIMAPSKK
DSEVEKESEK HSESSEEHFD SGVQEHIHST PPSRKTSSII TSDAPIIEPP AITSYANPIF
SRITGRPRSR PVTICGSGYE NVTSVNGSGM HSAPATNAVN QLFPPSSSLP THSIFADSKN
GDANVVETGN RHKLSVPSMP FAPQKKLSNG NQNNLLVTDC PPSSPNSRRE NIYVGSESKM
TGSHSSLSIH SKINGTENKI MQKQPEKGKK TAEASDSDLF STDEDLFGSE GPSDEDNGEP
FFPASEDIPV IRSTKHPWEN EQQYQQRLLS EKEEEEEERR EEEEKEREIE AQLAVLNRHT
PMMRELAKRK RRLLKPKIPP DRKPFTKAMT SLKRVKFTEE DYDVAMTVAL GNLESDHPLK
SDNSDFEEFV REQERCLPCQ HEVKENKREK EYVNWLKNIS EENQMFFAKS LSDPCAVFQL
SHLDSYMTDA EKARKTASHL IEFIKMFYFI KWEELLKIDN DFMLKEVYEL WQDYRNKRPR
VCRTHFRDYQ FRFFASSIAT KMKQYLITDE SPTVKQGLLN YDWLHLKPCV NTLNDDLATI
DDMMDTVVQR NPNWTTEEKA VANRYWDLFG DVPLHIETTD RVAVPPLSED QLEIIDESNC
WTKKMIKKAL YNARKYDIKL TYTKQKKQKD MFYVQERSEK VLNREWQMRL EKMVNETRHV
DLAMSTFRIN PNDKLIYTTD EHHPWPICQF DTGNHYVTVQ PMVSRRYHQM KSRVRRKFTF
RRTHKAVKNA KHIAITTDEL RKLPSFKRFE PKLQKATEFK NMMSKHYKVV DRAIVENRHH
LNTIVEEDDE VALIVQMLEN RPFKSGKRRL DSEDVFAERR EQIDYRDRDV LTRMIAEKYR
KQLEDYEKHE AAKMKIMKKH WMPELRRKIH VARRVIEIGR LMVEEDVRKW MEYQYELMFA
KKTFRKNSYI TKKLMSNNVP VEWLDSVDDI DFEEPFSPPV YAKPLTPVAR YKWNPGPSAY
NSSSDEEDYD PDDEKPEDDV FVTFETQPDL PVIAGKLQNI IKEKLELADD LVDDEWEYSD
DSSVSTWFDN DTDDIVNRLI NKDYVDEHIV LKERLKGPLG RKLWEVMAER QSPEPLSDEE
ENTSFDLMLR KDEEEKEKKQ AEWMEENADL DDIGVSDGKT RKEVTKMETE RDSLKYFKRE
DRKKEMDQIR WFFKKFALDH SYTSEPYVWN DELHEAIATM HRSELRRVGN RIHQNMKNDY
ELRMMQDDMV TEIIPADETS LQYKLINFLS FRNDGESFEK SSMRAADCSK MLKPIQQYEM
FFGREGAYKL KSIGDDMLAY QDIRNSFKYL SRHWGDNRCI SAEAVRRFVK VWWYNSKVTL
QRFLSSCKVR METMETGGQI FDSMVHWYYN CQNRKIAQET FDQLEIGCLM NDILHTVDEY
VEETEMLCRM TTSLEEKKAY STMDYFDWYY FKHGYPDWYE SEEDTESDSS ASSVSEIIPI
TEDSKPNSLK ANGLLSEDHA SPIKIMPDQP RRASEIEEEE DHQSVNPFTR RRKSVLTGNP
NKEMMDHYSK VYNKLKELEI EKRRKQEEEA AKLTVARWEQ AEREKLWDIE DMEKKVHDFL
MMNLSIKEKE GREDPDKIPY KDWRDVMENS EEDGYKDVPS CAMYGKSDMS TIKVLEMCGL
PLSLDNQLFV MEMDECQSAA TSVSDAEEIA SVIEKDFVDD KFGTSPDIDD DAKSYSSTRH
VLKHELHFQR DLECRRLPSC VLLFKPEEFF ENPTDTTREF TKWKRIIEAS ECPFSFNKLV
MRERLIQKCR EECQYGLMER YFATNERNHK SVIEVFKNCF ILVVVDTELK PWDCRVVSLD
DVSKPAKDKI SYLRKLMVED SQEQLVKWLE INKIDMEVYS RCPVLIVTDE NLTLSHATQM
SEFLIDDRVK DEWLIIKREE GVRALDAIIR MPPPPSHKLE AYKVIFKPIY DAWYKVWSFE
NAQSNARTPV VRKFDPVKEY LHKARMIVNY AHQHYRMKRF DSLMSKDPTE FQLVDRSDVP
SASLFDSLDA AVSKFCNEDS THLDEPSKQV VKDTLIQLAT GKIPYFTTNY FGGYDYTENV
CGLFTRIKNF MSFFQLGLTT QEDEENDDDR LPILRNTDFV QPDTPNAKYL DMEDCEEEIE
WLRNMYEESD FHRRRFMAVL MFELAQKAMF KFAPNMGDFE KAKNRFEHLL TMHAKQRPLL
DMMITKVRGT YFMPLETNLF LYNSKLITFG ELVDSEIHPE DWKNKKISFE DYRRQFPKEP
HAMSDFLEMN ENDSDTDSGS EVRSDTSSSL GSSTESLNSS KKARRTRKTI NKAQRELMLM
KLRSKPVNPD EVFALEKRAL GPKKWKLRRR LNEYLESIAD LDRNKLEAKL PAKKQDLLKY
ITDLIVNNSD TAHWSWGDLK MKTKVGLIPP VNRMRPKHFN RIMKGKKMYK PPKKYDLNDA
QSNGRKWF
//
