ID E3M2W7_CAERE Unreviewed; 173 AA.
AC E3M2W7;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=CRE-VHL-1 protein {ECO:0000313|EMBL:EFO89894.1};
GN Name=Cre-vhl-1 {ECO:0000313|EMBL:EFO89894.1};
GN ORFNames=CRE_07297 {ECO:0000313|EMBL:EFO89894.1}, FL81_01747
GN {ECO:0000313|EMBL:POM52296.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EFO89894.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|EMBL:EFO89894.1};
RG The Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:POM52296.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PX356 {ECO:0000313|EMBL:POM52296.1};
RX PubMed=26114425; DOI=10.1371/journal.pgen.1005323;
RA Fierst J.L., Willis J.H., Thomas C.G., Wang W., Reynolds R.M.,
RA Ahearne T.E., Cutter A.D., Phillips P.C.;
RT "Reproductive Mode and the Evolution of Genome Size and Structure in
RT Caenorhabditis Nematodes.";
RL PLoS Genet. 11:e1005323-e1005323(2015).
RN [4] {ECO:0000313|EMBL:POM52296.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PX356 {ECO:0000313|EMBL:POM52296.1};
RX PubMed=26394399; DOI=10.1371/journal.pgen.1005497;
RA Fierst J.L., Willis J.H., Thomas C.G., Wang W., Reynolds R.M.,
RA Ahearne T.E., Cutter A.D., Phillips P.C.;
RT "Correction: Reproductive Mode and the Evolution of Genome Size and
RT Structure in Caenorhabditis Nematodes.";
RL PLoS Genet. 11:e1005497-e1005497(2015).
RN [5] {ECO:0000313|EMBL:POM52296.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PX356 {ECO:0000313|EMBL:POM52296.1};
RA Banno H., Chua N.-H.;
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the VHL family. {ECO:0000256|ARBA:ARBA00010057}.
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DR EMBL; DS268422; EFO89894.1; -; Genomic_DNA.
DR EMBL; LFJK02000005; POM52296.1; -; Genomic_DNA.
DR RefSeq; XP_003109752.1; XM_003109704.1.
DR AlphaFoldDB; E3M2W7; -.
DR STRING; 31234.E3M2W7; -.
DR EnsemblMetazoa; CRE07297.1; CRE07297.1; WBGene00058310.
DR GeneID; 9803685; -.
DR KEGG; crq:GCK72_023767; -.
DR CTD; 9803685; -.
DR eggNOG; KOG4710; Eukaryota.
DR HOGENOM; CLU_116090_1_0_1; -.
DR OMA; NHPWVAR; -.
DR OrthoDB; 2951928at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; IEA:EnsemblMetazoa.
DR GO; GO:0001666; P:response to hypoxia; IEA:EnsemblMetazoa.
DR CDD; cd05468; pVHL; 1.
DR Gene3D; 2.60.40.780; von Hippel-Lindau disease tumour suppressor, beta domain; 1.
DR InterPro; IPR024053; VHL_beta_dom.
DR InterPro; IPR037140; VHL_beta_dom_sf.
DR InterPro; IPR036208; VHL_sf.
DR InterPro; IPR022772; VHL_tumour_suppress_b/a_dom.
DR Pfam; PF01847; VHL; 1.
DR SUPFAM; SSF49468; VHL; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008281}.
FT DOMAIN 22..91
FT /note="von Hippel-Lindau disease tumour suppressor beta"
FT /evidence="ECO:0000259|Pfam:PF01847"
SQ SEQUENCE 173 AA; 20113 MW; DDDACBCA4B31409B CRC64;
MDGNDSTRLF PDLGASPLVS QEIRVRFVNR CCFPIDVFWL SQEKEPTKYA TLKEKQYLDV
RTYKNHPWVA RRAVDGCKLQ MNTNPIYWPE PTAHANLIVR SYCNITLKIQ SLREIACHTL
LHETPSEIKE QLVNLPRELQ DEVNKAIDTK KEYCEVVCRF PTVRAAPPRE EPV
//