ID E3M593_CAERE Unreviewed; 847 AA.
AC E3M593;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=CRE-NCX-3 protein {ECO:0000313|EMBL:EFO92387.1};
GN Name=Cre-ncx-3 {ECO:0000313|EMBL:EFO92387.1};
GN ORFNames=CRE_11054 {ECO:0000313|EMBL:EFO92387.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in);
CC Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033667};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC8 subfamily. {ECO:0000256|ARBA:ARBA00007489}.
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DR EMBL; DS268425; EFO92387.1; -; Genomic_DNA.
DR RefSeq; XP_003108695.1; XM_003108647.1.
DR AlphaFoldDB; E3M593; -.
DR STRING; 31234.E3M593; -.
DR eggNOG; KOG1306; Eukaryota.
DR HOGENOM; CLU_012872_1_0_1; -.
DR InParanoid; E3M593; -.
DR OMA; CMVGLKD; -.
DR OrthoDB; 462435at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 2.60.40.2030; -; 2.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR PANTHER; PTHR11878:SF76; NA_CA EXCHANGERS; 1.
DR PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR Pfam; PF03160; Calx-beta; 2.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR PRINTS; PR01259; NACAEXCHNGR.
DR SMART; SM00237; Calx_beta; 2.
DR SUPFAM; SSF141072; CalX-like; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|ARBA:ARBA00022568};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT TRANSMEM 26..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 669..691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 749..768
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 780..800
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 820..842
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 352..453
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 471..576
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
SQ SEQUENCE 847 AA; 94391 MW; 2C931BFEE9198B70 CRC64;
MSYAANLTCK SGILISALET TPRNALLYLA ALFYCFLGIA IAADIFMCSI EQITSATRKV
KRQKKVGRLV SKEEEDGDEE QFEYIRIWNP TVANLTLMAL GSSAPEILLS IIEIVGNGFK
AGDLGPGTIV GSAAFNLFCI SAICVFAVGQ TTKRIELYRV FVVTAFFGTF AYIWVFLFKV
KSVLDLDACF QVLIVITPNV VDVWEAVLTL LFFIILVVLS YSVDVEIWKK KRASDLQEEL
ELAQQDGGKV DDDKPEKLSN EIKKWASTFS LTHEDTNAVV VDSTPSVDTV RRWTRTISAT
YPSLSEEDQA KLLAYRVSRT MSHDRLYYRI RAIRQLSSSW RKSEEEEVQM IEKQESTDSG
NRKKTFVEFS ARVYRVDSTD ETVSLKIVRK GNMDSKFTVH YSTVNGLAKK DLNFLFKAET
LQFNPGELHK TITVKLINAS NWRPNDVFYV HLKIQDEDED AKIRLGACNI ARVKMPDESA
MMLGGPLVEF VKPNYVVKEN AGYARSFISR KGGKLKDPLR IRYETEDVTA KQGEDYTSVK
DGIIVFEGQE YEKYIDIDII DDKMDEKDEA FIIELLKVEE GDVSIGTRRK ATITIISDDN
VLKNITNVHK LMGHYMRQLR PGKATWKEQI LNAVSVNAGD LANATVSDCI LHALAFPWKF
AFAFLPPPTI FYGYPCFIVA LVAIGLVTAV VGDVASIFGC MVGLKDAVTA ITLVALGTSL
PDTFASKIAA ESDDTADNAV GNVTGSNSVN VFLGLGLPWV IASLYWASKG ESFRVDAGDL
GFSVTVFMIC SVLFLVVLVL RRKLELFGKG ELGGPFGPKT LSTLFFVSLW IVYVSLSIWN
MYRTDNK
//
