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Database: UniProt
Entry: E3M7H8_CAERE
LinkDB: E3M7H8_CAERE
Original site: E3M7H8_CAERE 
ID   E3M7H8_CAERE            Unreviewed;      2951 AA.
AC   E3M7H8;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   16-JAN-2019, entry version 42.
DE   SubName: Full=CRE-ITR-1 protein {ECO:0000313|EMBL:EFO93941.1};
GN   Name=Cre-itr-1 {ECO:0000313|EMBL:EFO93941.1};
GN   ORFNames=CRE_12532 {ECO:0000313|EMBL:EFO93941.1};
OS   Caenorhabditis remanei (Caenorhabditis vulgaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN   [1] {ECO:0000313|Proteomes:UP000008281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG   Caenorhabditis remanei Sequencing Consortium;
RA   Wilson R.K.;
RT   "PCAP assembly of the Caenorhabditis remanei genome.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DS268427; EFO93941.1; -; Genomic_DNA.
DR   RefSeq; XP_003108042.1; XM_003107994.1.
DR   STRING; 31234.CRE12532; -.
DR   EnsemblMetazoa; CRE12532; CRE12532; WBGene00074864.
DR   GeneID; 9828368; -.
DR   CTD; 9828368; -.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   InParanoid; E3M7H8; -.
DR   OMA; PRHAPYK; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000008281; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblMetazoa.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0017022; F:myosin binding; IEA:EnsemblMetazoa.
DR   GO; GO:0030421; P:defecation; IEA:EnsemblMetazoa.
DR   GO; GO:0048598; P:embryonic morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0048815; P:hermaphrodite genitalia morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0060179; P:male mating behavior; IEA:EnsemblMetazoa.
DR   GO; GO:0006936; P:muscle contraction; IEA:EnsemblMetazoa.
DR   GO; GO:0001556; P:oocyte maturation; IEA:EnsemblMetazoa.
DR   GO; GO:0012501; P:programmed cell death; IEA:EnsemblMetazoa.
DR   GO; GO:0030334; P:regulation of cell migration; IEA:EnsemblMetazoa.
DR   GO; GO:0051489; P:regulation of filopodium assembly; IEA:EnsemblMetazoa.
DR   GO; GO:0043051; P:regulation of pharyngeal pumping; IEA:EnsemblMetazoa.
DR   GO; GO:0007622; P:rhythmic behavior; IEA:EnsemblMetazoa.
DR   GO; GO:0042713; P:sperm ejaculation; IEA:EnsemblMetazoa.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008281};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2508   2526       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2538   2555       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2561   2578       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2627   2653       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2674   2696       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2793   2815       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      196    250       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      323    383       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      390    448       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      507    568       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1933   1953       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2951 AA;  337016 MW;  8608DAA7CE840EC5 CRC64;
     MNSTFGRVRK KVSIISVPEF APDSYENENV ATSGGIVGIG STSRGSTRIE FDFDDFEEQI
     MRKSSMALPS RKLTIASSID HGNNGNLHIG DIISLYTESS TNQEQRGFLS TLGLVDDRCI
     VELKDGRPES PPKKFRDCLF KVCPVNRYAA QKHLWTEQKR FQTGDSMFDD DLMNKLRVAA
     DKEREENEAE FQKTLGNVVQ YGSMVQLLHV KSNKYITVQK NSPAKRERNA MKVYLDRAGN
     EGSWFIIEPA YKHYAIGDNV SAGNKISLIP NAVSTTQTGH VKSQLHLSGF NLLDHQTAAE
     VNCLNEPTEW QVFMFLLFDE NQQNSVKSGD VVRLFHADQQ TFLTLDTIPK INPAKDVVFL
     RMTNRPSAAD ATSSRALWEV QVVQTNAYRG GTAKWNKTYR FKHLASDMYL TVEASQIQVK
     PAVNGRRASL IYSKTNNPMA SMYSDGPNGI TNGTDKMKLH RQINIPDSSD ASNGPNVYFL
     SPTKSDFPES NENLLFQLDP STFMKSNKDV PRRSYVRLLH QSTDTWVHAT NATEKQNLHF
     SNKNEKGWVK VICETNRVDK ETFALLPVNP DEVRDLDFAN DACKALRNFI NLIKIGSVIS
     KEALNSTTQL LIDCILFVTN SSDHLADPLK ITDFSPSRDR QKLLREQEVL HQVFLLLKAP
     FQPRQGSTEL GPLLSSPAEL SDSRNEIFKT MFQLCYCLLK YSQVSYRKNQ EFLAEKFGEI
     QEQIGFDLMA EDTMTAVLHN NPKLLEKYVK APHVERFVEL VRNNRQGKFL DYLADLCVCR
     GEANKKIQEL ICTSVLSNTH RDIFMDTKVI EGEIEVGWAP NFRKLVDIAE GAKSNHDDVE
     HLDYYRFVGD LMIVNDTFFT FSHQLDLLSQ MCQEQQYLAI DPPLERGLMN ISQQLPAELV
     LQCMSDTRLP YDLRGSFTRL MLHLHVVRGS PMSAIRHARL WWSIPENVNV STYESVSVEA
     YSDGSRMRIG ASIAHKVLAT VETYLMALRN QSTDERHSVN SSKLTYEVSV TRGETYPKYF
     CFQIVNLAKA LAQFNFYSFN ELLQLTQNLL AIINEGPSVE QVPSHRAMVN AIRNMSKSMM
     RGGSNKESSK DLAKTSSMST DDAGRSKEGR ALIVKTKLIV AEILQFVMDV RRDYRITMAL
     SWFKNVFPCD EDGSLMHSAS INERMASELY DAIYHSSGHE LHLDGKDGQL LLAILLQMTM
     SDYPPLTSIA LKVLFRHFTQ YQELLEDLKQ VQLLVSNDDV ENYRQIDRDL FILKNLTEKS
     ELWVHGDRNH SVETKEVDDK ERTTEYDLQR HELNTPRAFG SRDSMDAVIA VINEHYSNFK
     TESLQLLNRL LIKDDRNDAA VALQELSDKA PLIAYPLIRQ MLVRLTRMCY RDGKPDTMNQ
     QLLKNMRVYE VVLEFISVPH DKKHDHEMMK LITLSHEFLR SFCKTNKENQ SRLYKFISYE
     KDAKEGMLRV ETVEEVGTLV AIFRNNRELA SNVPEELIAH IVGLIEHNSR NPIFLELLQA
     LVCVYDKEIE SGQEKVANEI CAASDEVRQL YVDNASFEEL EALMKQEKES RGRETDSRKP
     LKYHIELVRL LAMCTRGKNG NTELKCASQI PMDHIVRVVT SKHCLVEVKT VYLQLLLHCY
     IDTDAEMKDA YKTEYVDNIL NNLLEDIRSL RIEKLTDAET VTLEHYICHT VTEVLIKFFE
     APYSALQQAK VDVHHHKKTF SEVLLELTSL ERGKLKSTRS SRNWYRVAEC IKRLTKWAEE
     HSITLPATLA GPQMAGTASV RQKWQNAATS AKLIGLNKRL NRQNTLNPGH RLYGTSNSMT
     EHTSANVVTC YHVSYSRGEC IQMMIGEFKF YLHPLHAAEG SVLVEVLHTP ELLFPEGSSL
     RDQCARGGVV AKLIQHCKTL MQNKQDNLCA RVLQTLCKMC DCTKQQLTQQ GQQLRQLLLQ
     RYFGQHNHHH PPLDRQQSKI GEVIEAVKEK KEETWSQERD LYAIQCKLND AGASDLVTDI
     IIMEPSREIF LKAIHLARAL LHEGNDKVQH SFYMRMKQKD IHEPFFKVIL TRIQTAQNRL
     KSDMMSCSDS KPKASLSATV SRRSSTVLTP LIDAGDSGFN GTLFEVPQQV RHPSISEMSQ
     LSNDLTHSIP DLTPYQDEDK STDALPPEVA LVEPILRVLQ LLCENHNSLL QNFLRKQSDR
     TNHNLVSETL SFLDTVCGST KGSLGVFGEI GEHNFSLITQ TLATLTEFCQ GPCHENQNTM
     AMQENGLNII ISLVLNEIKP LADDHMELAL EIKSQASKLL LAIMESRHDG ENANRVLRNM
     ANMSGGPKQL VHAIKQAYEM TNSNHHMLKS VSRDLFRRAE DDSKNKPGPQ ITVNTISLPE
     INVDASGIVS IHTEKNNSSS LDDKFHEEDC PSVDPREVGH NIYILAHQLA IHDGELEIWL
     DGSDEKKDDL TREALNYYKE RTAQIEIVRR DRTLERVVFP INDICSYLTK ETKDYVYNNT
     ERDNQGSKVT EFFDQWETMY HEMIWQRKLQ DRKWLSWCAF RLPLWTRLSF HFAFIVNALV
     ACYYPFPEHS TTPISFGNSY SWLAVITSFL LAHYLRHDKS YLPKTFLLIL ASLCFLFVSS
     IGVNITLYFF GILQLVNKVV HVLAFVSNKG LEDRPLSEIL ACRNLHYLLV YLAVCIAGFV
     IHPMIYCALL FDIIATEETL QNVIASVTRN YQSIVWTGLL ALILLYGFSI LGFLFFRHDF
     YLDVDPVEAD SSATISSGLP SETCPSEGCP GLKPTGKDGD DDDDKKIKSC ETLWMCILQT
     MYLGLRNGGG IGDVLRNPAP WEDMFVWRVA YDMTFFVVLI VIVLNLIFGV IIDTFGDLRA
     EKNEKEQILK NNCFICGLDR SRFDNRSVTF ETHRETEHNI WHYLYYIVML QIKDETEFTG
     PESYVAQCVK DRNLDWFPRM QALSLQDSEL DTDQSEMKQM KDQMMQMIAM MRENQSQWDE
     VRAFMEQLQS R
//
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