ID E3MBQ5_CAERE Unreviewed; 531 AA.
AC E3MBQ5;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=Neurotransmitter-gated ion-channel ligand-binding domain-containing protein {ECO:0000259|Pfam:PF02931};
GN ORFNames=CRE_15945 {ECO:0000313|EMBL:EFO97848.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DS268433; EFO97848.1; -; Genomic_DNA.
DR RefSeq; XP_003106546.1; XM_003106498.1.
DR AlphaFoldDB; E3MBQ5; -.
DR STRING; 31234.E3MBQ5; -.
DR EnsemblMetazoa; CRE15945.1; CRE15945.1; WBGene00061060.
DR eggNOG; KOG3645; Eukaryota.
DR HOGENOM; CLU_018074_2_6_1; -.
DR InParanoid; E3MBQ5; -.
DR OMA; WHIQNIE; -.
DR OrthoDB; 2881414at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18989; LGIC_ECD_cation; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR PANTHER; PTHR18945:SF475; NEUR_CHAN_LBD DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 292..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 512..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 47..217
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
SQ SEQUENCE 531 AA; 60749 MW; 752A6D6E0FDBCF93 CRC64;
MLLLRIFPIS ELNFQFFFHF EKNKVVSSVL LLSWHIQNIE SAPEDDRQLQ KDILKSYNPK
IRPVKVETTV TQVSVFLNIA HVEKVDEEEQ TALVHGHLWA SWIDEYLVWD RKKTNITKLT
VPSSRIWQPA LALYNSARGN TWHLYMNGLP ATVYYTGKVW SSGTFSFFVT CQFDFTNWPF
DQQSCPIVIA DWVYGLAQVN LSDPNTVAEY AKPSIRLSYD PIEKKNKRHV GGWEVKDAWK
KHCYWGPKGC KEDPPEGEPD WYWSLLEFGI ILKRHLPYFQ LTVMLPLVGK KIYLIILTSL
LVLLGFWIET FSTNVIMIVF NVVLQATYGW NMIRQLPPGS GGTPKVVQLY TMNIFISSFQ
ILLISISKFL EESLPEKFAF NFGIDITEIP KKMGIDALFA KKGLSFDPNT LFTDQDDPES
LESVLEKGGG SPSTSIGIGN PLNDEEFDNF QNSTASSTTS ETELLINLPT NSEPALAESV
EHIGVEDAKK PVIKQPEPER KLSVQLHHIK RFLFFLNVLV YIIAFLLVLY Y
//
