ID   E3MF08_CAERE            Unreviewed;       732 AA.
AC   E3MF08;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   SubName: Full=CRE-HIF-1 protein {ECO:0000313|EMBL:EFP00809.1};
GN   Name=Cre-hif-1 {ECO:0000313|EMBL:EFP00809.1};
GN   ORFNames=CRE_21153 {ECO:0000313|EMBL:EFP00809.1};
OS   Caenorhabditis remanei (Caenorhabditis vulgaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN   [1] {ECO:0000313|Proteomes:UP000008281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG   Caenorhabditis remanei Sequencing Consortium;
RA   Wilson R.K.;
RT   "PCAP assembly of the Caenorhabditis remanei genome.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DS268440; EFP00809.1; -; Genomic_DNA.
DR   RefSeq; XP_003105348.1; XM_003105300.1.
DR   AlphaFoldDB; E3MF08; -.
DR   STRING; 31234.E3MF08; -.
DR   EnsemblMetazoa; CRE21153.1; CRE21153.1; WBGene00063549.
DR   eggNOG; KOG3558; Eukaryota.
DR   HOGENOM; CLU_023954_0_0_1; -.
DR   InParanoid; E3MF08; -.
DR   OMA; WLFRDQP; -.
DR   OrthoDB; 5396877at2759; -.
DR   Proteomes; UP000008281; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:EnsemblMetazoa.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:EnsemblMetazoa.
DR   GO; GO:0061433; P:cellular response to caloric restriction; IEA:EnsemblMetazoa.
DR   GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
DR   GO; GO:0010286; P:heat acclimation; IEA:EnsemblMetazoa.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IEA:EnsemblMetazoa.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
DR   GO; GO:0048678; P:response to axon injury; IEA:EnsemblMetazoa.
DR   GO; GO:0001666; P:response to hypoxia; IEA:EnsemblMetazoa.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   NCBIfam; TIGR00229; sensory_box; 1.
DR   PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR   PANTHER; PTHR23043:SF17; PROTEIN SIMILAR; 1.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF14598; PAS_11; 1.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008281}.
FT   DOMAIN          11..65
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          86..156
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   REGION          406..425
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          437..556
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        456..541
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   732 AA;  81530 MW;  21E1371856ABC29B CRC64;
     MEDNRKRNME RRRETSRYAA RDRRCKEGEI FDELKQVVPI VEEGTVTHLD RIALLRVAAT
     ICRLRKTAGN VLENDLDTEF NNEVWNEETI AECLDGFVMI VDSDSSILYV TESVALYLGL
     TQTDLTGRAL RDFLHPADYD EFDKQTKLIH KPKDEEYDST GINMVLRMKT VISPRGRCLN
     LKSALYKSVS FLVHSKVSTG GHVSFMQGIT IPAGQGTTNA NASAMTKYTE SPMGAFTTRH
     TCDMRITFVS DKFNYILKSE LKTLMGTSFY DLVHPADMTI VGKSMKELFT KGHIRTPYYR
     LIAANDTLAW IQTEATTITH TTKGQKGQYV ICVHYVLGIQ GAEESLVVCT DAMPAGMQVD
     IKKEIDDTRD YIGRQPEIIE CVDFTPLIEP EDPFDLIEPA AVMVRQREPE QQEPVVSKPA
     DMGTRKDSYD DVLQWLFRDQ PSSPPPTRYR SADRFRPSPE TSNFDTAMAS PQFMDSSSRA
     SRPKTSYGRR AQSQGSRTTT SSSSGSANAT QPHSANYSPL AEGISQCGLN SPPSLKSSQI
     MYGDSRPMVG RCGPSDSSRR FSAIPVSDTL DVPSAGLAGC HDEVITDVFA TMPFTDSLIA
     QEQCEDGNGL NNSSPTLANG CEPIICDNLE WEEPDLSCLA PFVDSGDMLQ IGDGYSPEFQ
     ALYDLPDFTP AVPSAPAARP VHIDRSPPAK RMAPSEMDFM YTNNQYQPAF QESQYWQPTR
     DNSHQQGNYP SY
//