ID E3MFB2_CAERE Unreviewed; 770 AA.
AC E3MFB2;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Proton-coupled zinc antiporter SLC30A5 {ECO:0000256|ARBA:ARBA00040846};
DE AltName: Full=Solute carrier family 30 member 5 {ECO:0000256|ARBA:ARBA00042217};
DE AltName: Full=Zinc transporter 5 {ECO:0000256|ARBA:ARBA00042038};
GN ORFNames=CRE_20737 {ECO:0000313|EMBL:EFP01058.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+)(out) + Zn(2+)(in) = 2 H(+)(in) + Zn(2+)(out);
CC Xref=Rhea:RHEA:72627, ChEBI:CHEBI:15378, ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00034428};
CC -!- SUBUNIT: Heterodimer with SLC30A6/ZNT6; form a functional zinc ion
CC transmembrane transporter. {ECO:0000256|ARBA:ARBA00038531}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004557}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004557}. Cytoplasmic vesicle, secretory vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004638}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004638}. Golgi apparatus, Golgi stack membrane
CC {ECO:0000256|ARBA:ARBA00004205}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004205}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS268441; EFP01058.1; -; Genomic_DNA.
DR RefSeq; XP_003105160.1; XM_003105112.1.
DR AlphaFoldDB; E3MFB2; -.
DR STRING; 31234.E3MFB2; -.
DR EnsemblMetazoa; CRE20737.1; CRE20737.1; WBGene00060873.
DR eggNOG; KOG1484; Eukaryota.
DR HOGENOM; CLU_013430_11_0_1; -.
DR InParanoid; E3MFB2; -.
DR OMA; NINTDRL; -.
DR OrthoDB; 1218545at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006882; P:intracellular zinc ion homeostasis; IEA:InterPro.
DR Gene3D; 1.20.1510.10; Cation efflux protein transmembrane domain; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR InterPro; IPR045316; Msc2-like.
DR NCBIfam; TIGR01297; CDF; 1.
DR PANTHER; PTHR45755; -; 1.
DR PANTHER; PTHR45755:SF1; ZINC TRANSPORTER 5; 1.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF161111; Cation efflux protein transmembrane domain-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 25..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 52..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 492..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 529..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 584..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..633
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 554..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 746..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..762
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 770 AA; 84858 MW; 20AC89E818385FD7 CRC64;
MLAQDFVKKD DRNFTPTQSS RSASYFVVLV LTKILRCIGI FFVDILAKSS HIVNLLWLCK
IICTCILFPL QKPLSAGKSL KRGLLPMILK LSLLNGVIEI LWFYGITLCG PLRSVLVFEL
SSTVLLSAIV SFFKGGAVST TSKTRGFFLL IVGFVALFLM DKDGTIEDPH HTTHAHHSGL
NHLFYHLIGL FGMADHKGGL CILILSLCLR TGYETTFRHL AVEVGGAKRL YTLVTAGSAV
ILTPVAVLSW ALSSSSIASM GFFEYSILLI IVAVFVFVLD FYAESICFQH VADPIMAAAR
WSSVTMFACA FGLAYLWYGH QNLGDHALTG GVSITVVCFI LGEFLKNFNQ IVVNGIEKLN
SFFSASISLT HSNAPKHRGG QFVGISNTGL PLFTYGEAFL QKTSKSLMRF MKDTLNEILA
NNDSRRIFWF LCVNLGFCGI EFLYGFWTNS LGLISDGFHM LFDCSALVMG LVASVMARWP
PSKHFTFGFG RVEILSGFIN ALFLCVIALF ILIEALERLF DPPNINTDRL LFVAVSGLLV
NLFGMYSLGE HGHSHGGSSH GHSHGGGGSH SHGHSHGNAN MQGVFLHVLA DTLGSVFVII
STLLIQWFGW VWVDPLCSLI LSLLIIGSVY PLLVSSVNTL LQDIPEEDEF EYHVNEILEI
EHVESYSNAH MWQHNDINVA SVHVQVKDEA NAQMVRHRVA NILKSTGAGH STVQVEKKAF
AHRIQQLCPN YKIGYTVVRG SVIRDKTQHG HSHDDGHGHS HDHSGGGHHH
//
