ID   E3MFJ9_CAERE            Unreviewed;      1321 AA.
AC   E3MFJ9;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   24-JAN-2024, entry version 58.
DE   RecName: Full=Rap-GAP domain-containing protein {ECO:0000259|PROSITE:PS50085};
GN   ORFNames=CRE_20789 {ECO:0000313|EMBL:EFP01014.1};
OS   Caenorhabditis remanei (Caenorhabditis vulgaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN   [1] {ECO:0000313|Proteomes:UP000008281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG   Caenorhabditis remanei Sequencing Consortium;
RA   Wilson R.K.;
RT   "PCAP assembly of the Caenorhabditis remanei genome.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DS268441; EFP01014.1; -; Genomic_DNA.
DR   RefSeq; XP_003105116.1; XM_003105068.1.
DR   STRING; 31234.E3MFJ9; -.
DR   EnsemblMetazoa; CRE20789.1; CRE20789.1; WBGene00060954.
DR   GeneID; 9802925; -.
DR   KEGG; crq:GCK72_001390; -.
DR   CTD; 9802925; -.
DR   eggNOG; KOG3686; Eukaryota.
DR   HOGENOM; CLU_006276_0_0_1; -.
DR   InParanoid; E3MFJ9; -.
DR   OMA; GSGWQRH; -.
DR   OrthoDB; 21929at2759; -.
DR   Proteomes; UP000008281; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   InterPro; IPR046859; RGPA/RALGAPB_N.
DR   InterPro; IPR027107; Tuberin/Ral-act_asu.
DR   PANTHER; PTHR10063:SF11; RHO GTPASE-ACTIVATING PROTEIN CG5521-RELATED; 1.
DR   PANTHER; PTHR10063; TUBERIN; 1.
DR   Pfam; PF20412; RALGAPB_N; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008281}.
FT   DOMAIN          1098..1299
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   REGION          542..580
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          977..1023
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1039..1064
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1321 AA;  146704 MW;  039F9B4A4C8167CC CRC64;
     MFARKGKSSD VQASISRFTD LNRDCVSRVK HLKILLDTLT TNEKRQLLDE HSFETFHLVD
     ELLLVNDVSS QIDSAIEAES GLWTLEQVLC LAPELVGSGW QRHAIESLLK KAVYPKNLMA
     VRKIAIRLFL VFYQCLGVYG KATPDLDRVF QCLLPFFPLK SGENAEDVLN EYCQSSGTGD
     WCERLRNGPI KSTASAAQTS KERAQMLQVY LDKFLEYCTR ETVRIEWNDE GKRQECANFI
     IDKVIKLYMG ECFTELETNG VDVFGGWEGA DEQGEPLDTA DPVVIARYWL IRWINNIASA
     THQPTNGPPQ SAHSSLILYR NALFSSHKAT NVALTLMREA MKLPLACSNV THKVVNVLSS
     WLLQYEIPPF VASGEVSIER CSLLLANILL SFFHSPYLAQ SGERHSSAIS IAFAILTSCK
     QLVSHRIQLP KPLPQKFWSE LMSGLCAVAS KICHQSDIFS QHVSAAFTST LISNVVIIKA
     VRRIEIDDDV WDEVHEVMKR GVWIPMAEQW AAIVNSVTRA LILHLAHIDI FSREEALRKA
     TEVSQTSRRQ AIESANAMEE PRKESSEAGD SMSSTNTISE DNVFHDTDDI TNAVTSWSGD
     KLAWLQTWRR VISLVDPYTN SSAHVAIDCM SLTIKNLLSV NLHPLAHWLA CRLVTVPPIL
     LPRCVPALSA ILNESSVRRP PPLLSANILL CFIRLMQSKE QSVVPAICGL SANELSIVAP
     RALEHLPKML QAARTSKDSK MSSNSLKLFA MLCSSYPGAE QILLDHLVHT DVSENAVVIV
     NTLAILIVQK AQIDLVLSAL KVIETHQFAM RLIPLFCSAI ATLAQFSSTT LLQALLRAAS
     LLRDERQRTE IEWQMVKLCV QWPQPQMPLV IRGILADRHM VLHGELVGLG GQYPIRGFDV
     SRWNSSGSQA PGSQATSQED KTVYINRQTA IISLSRPTPS KFEITSRTVV ARHIWDLDTL
     ETPRASTRHV TNWLRKEALK GKKPGRESQG ILGAMDDPFD DLPRAPSSAS TGTGSLGSGA
     LGSPVEGSAQ FASMIETSRR QPQPLGSGSG TMGSGPVGSG PTPAFTPNSK LLEWRSLSAS
     LGFVPLVSQV HTNFLRDLKH LDQTSSREVH KVAVIFVGDT QDDRASILSN TSASPQFDDF
     VSELGWEIKV GRGHEGYSGG LPVETRAPYY ADAESECIFH VSTWLNGDVQ QKWKHIGNDE
     VHVVWTENYR KVYTRETIAT KFCDVLIVLE HVGDKMVRVR VDTASALEFG PLFDGALVTM
     SELSQLVRLT VINASRAYRL ARVEHSRPLR HREEVFCNEA LGHMRPMALA QSINHLYVPT
     I
//