ID E3MIU6_CAERE Unreviewed; 377 AA.
AC E3MIU6;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
GN ORFNames=CRE_02372 {ECO:0000313|EMBL:EFP02535.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DS268448; EFP02535.1; -; Genomic_DNA.
DR RefSeq; XP_003103925.1; XM_003103877.1.
DR AlphaFoldDB; E3MIU6; -.
DR STRING; 31234.E3MIU6; -.
DR EnsemblMetazoa; CRE02372.1; CRE02372.1; WBGene00061941.
DR GeneID; 9802589; -.
DR KEGG; crq:GCK72_011561; -.
DR CTD; 9802589; -.
DR eggNOG; KOG3773; Eukaryota.
DR HOGENOM; CLU_018371_4_0_1; -.
DR InParanoid; E3MIU6; -.
DR OMA; LMASCYH; -.
DR OrthoDB; 5395310at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR033562; PLPL.
DR InterPro; IPR002641; PNPLA_dom.
DR PANTHER; PTHR12406; CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED; 1.
DR PANTHER; PTHR12406:SF21; PNPLA DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 4: Predicted;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281}.
FT DOMAIN 125..297
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 46..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 377 AA; 42003 MW; A4C649B6D45693C0 CRC64;
MTDTNKTDKD DGSRKRYPSL NPQVPFDAEI SNNYLIAFGD FSHFFDEEDN SSRKSAGSNE
ETSEKSPTSP DSDSESNSES NKENEEGKGK EAIEVELETK KAMPLRRARD PANRTPLQDA
PQICLSFGGC GFLGSYQFGA AKTIYDHGKE LLKRVVRYSG CSSGSLVATM LIFNPEKIPE
AVEEIYKMAD EVNETSLGAM SPGFVIGERL RRVVERFVPD DVSKANDLLY VSVTRLKTWK
NELISQFYSK SDLIDCLMAS CYHPMYSSGL SGKAPVLRGE AYIDGGYSNI LPEFLDKRTV
SVTAFAGDAD VCPVEKSALF NDWMFAFFNQ NMKMTFSNVK RVSNALFPPP RGMLQKYYEA
GAQDAEKLLK EAGMWND
//
