ID   E3MK54_CAERE            Unreviewed;       474 AA.
AC   E3MK54;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=Apple domain-containing protein {ECO:0000259|PROSITE:PS50948};
GN   ORFNames=CRE_28713 {ECO:0000313|EMBL:EFP03825.1};
OS   Caenorhabditis remanei (Caenorhabditis vulgaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN   [1] {ECO:0000313|Proteomes:UP000008281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG   Caenorhabditis remanei Sequencing Consortium;
RA   Wilson R.K.;
RT   "PCAP assembly of the Caenorhabditis remanei genome.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DS268451; EFP03825.1; -; Genomic_DNA.
DR   RefSeq; XP_003103451.1; XM_003103403.1.
DR   AlphaFoldDB; E3MK54; -.
DR   STRING; 31234.E3MK54; -.
DR   EnsemblMetazoa; CRE28713.1; CRE28713.1; WBGene00067782.
DR   GeneID; 9819147; -.
DR   KEGG; crq:GCK72_012002; -.
DR   CTD; 9819147; -.
DR   eggNOG; ENOG502TFXF; Eukaryota.
DR   HOGENOM; CLU_514127_0_0_1; -.
DR   InParanoid; E3MK54; -.
DR   OMA; CASINYS; -.
DR   OrthoDB; 2878725at2759; -.
DR   Proteomes; UP000008281; Unassembled WGS sequence.
DR   CDD; cd01099; PAN_AP_HGF; 2.
DR   Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 2.
DR   InterPro; IPR003609; Pan_app.
DR   PANTHER; PTHR47327; FI18240P1-RELATED; 1.
DR   PANTHER; PTHR47327:SF15; PROTEIN CBG00402; 1.
DR   Pfam; PF00024; PAN_1; 3.
DR   SMART; SM00473; PAN_AP; 3.
DR   SUPFAM; SSF57414; Hairpin loop containing domain-like; 2.
DR   PROSITE; PS50948; PAN; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..474
FT                   /note="Apple domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003175105"
FT   DOMAIN          31..111
FT                   /note="Apple"
FT                   /evidence="ECO:0000259|PROSITE:PS50948"
FT   DOMAIN          268..346
FT                   /note="Apple"
FT                   /evidence="ECO:0000259|PROSITE:PS50948"
FT   REGION          449..474
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        449..468
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   474 AA;  53390 MW;  BF37F8A0D5ABC89A CRC64;
     MLLQRLLIIA VLVALYGSSS ALYRSKDVFS CFILHSNEFL EKSGNVLIEN IDDVNECLRK
     CIQAPMNHKI KCKTVMYNVN TQNCVLSKYA RHERNIKKSK GLQIDLYENR CATTENETVR
     LAVFTEQTRT TAAPVKTVAV IGNVILTPMN VTTTNAPIIT TQQAVPTTNE LRRVHAVKQF
     PLDQKNGNVI FSKTVYADQP SPQLLPQRLT DKRNRNAKVF ISPRPLVDST STVVSSPTYQ
     QQQLQFDVAR ERRQRSERPP VVENLAACFI KTPNRILYKF EESRIGGVTL ETCMRQCTHN
     ALNFYCASIN YSFGLKVCTL NGGNLHLNGG ETLVASRDYD YFENTCQPRG TTTTESSIGG
     SGTKKECYRL YNNSIYNSFD ATIVGGLQDL ESCESECSWS HIRRREKCLG VNWIPTTRGC
     MLFHKQIDFN ILQPSFKAQF LANTCTYTTD QSSSRSSSSS SKSGSDPDYY DPNH
//