ID E3ML97_CAERE Unreviewed; 259 AA.
AC E3ML97;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Protein-tyrosine sulfotransferase {ECO:0000256|ARBA:ARBA00013262, ECO:0000256|RuleBase:RU365018};
DE EC=2.8.2.20 {ECO:0000256|ARBA:ARBA00013262, ECO:0000256|RuleBase:RU365018};
GN Name=Cre-tpst-2 {ECO:0000313|EMBL:EFP04426.1};
GN ORFNames=CRE_25658 {ECO:0000313|EMBL:EFP04426.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the O-sulfation of tyrosine residues within acidic
CC motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as
CC cosubstrate. {ECO:0000256|RuleBase:RU365018}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] = adenosine
CC 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein];
CC Xref=Rhea:RHEA:16801, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:11688,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:46858, ChEBI:CHEBI:58339,
CC ChEBI:CHEBI:58343, ChEBI:CHEBI:65286; EC=2.8.2.20;
CC Evidence={ECO:0000256|ARBA:ARBA00000411,
CC ECO:0000256|RuleBase:RU365018};
CC -!- SIMILARITY: Belongs to the protein sulfotransferase family.
CC {ECO:0000256|ARBA:ARBA00009988, ECO:0000256|RuleBase:RU365018}.
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DR EMBL; DS268454; EFP04426.1; -; Genomic_DNA.
DR RefSeq; XP_003103097.1; XM_003103049.1.
DR AlphaFoldDB; E3ML97; -.
DR STRING; 31234.E3ML97; -.
DR EnsemblMetazoa; CRE25658.1; CRE25658.1; WBGene00064855.
DR GeneID; 9819539; -.
DR KEGG; crq:GCK72_011885; -.
DR CTD; 9819539; -.
DR eggNOG; KOG3988; Eukaryota.
DR HOGENOM; CLU_046916_0_0_1; -.
DR InParanoid; E3ML97; -.
DR OMA; SWFDCFS; -.
DR OrthoDB; 2873684at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0008476; F:protein-tyrosine sulfotransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR026634; TPST-like.
DR PANTHER; PTHR12788; PROTEIN-TYROSINE SULFOTRANSFERASE 2; 1.
DR PANTHER; PTHR12788:SF7; PROTEIN-TYROSINE SULFOTRANSFERASE-RELATED; 1.
DR Pfam; PF13469; Sulfotransfer_3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365018}.
SQ SEQUENCE 259 AA; 30017 MW; 82543206801D8588 CRC64;
MRAILDAHPD VRCGGETMLL PSFLEWQAGW RNDWVNNSGI TRDVFDDAVS AFITEIIAKH
GELAPRLCNK DPYTALWLPT IRRMYPNSKF ILMIRDARAV IHSMIDRKVP VAGYNTSDEN
SMFIHWNQEI RKMLFQCNKS PGQCIKVYYE RLIQKPSEEI QRITYFLDLP YSTQMLKHHE
LIGAEVDLND QEFSASQVKH SINTDALTSW FDCFSEETLQ KLDDLAPFLS ILGYDTSAAK
PDYSMFADDN FYQFRNAYS
//
