ID E3MRW9_CAERE Unreviewed; 1099 AA.
AC E3MRW9;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN Name=Cre-vab-1 {ECO:0000313|EMBL:EFP08186.1};
GN ORFNames=CRE_17286 {ECO:0000313|EMBL:EFP08186.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; DS268471; EFP08186.1; -; Genomic_DNA.
DR RefSeq; XP_003101102.1; XM_003101054.1.
DR AlphaFoldDB; E3MRW9; -.
DR STRING; 31234.E3MRW9; -.
DR EnsemblMetazoa; CRE17286.1; CRE17286.1; WBGene00065095.
DR eggNOG; KOG0196; Eukaryota.
DR HOGENOM; CLU_000288_141_4_1; -.
DR InParanoid; E3MRW9; -.
DR OMA; GYSQIAD; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IEA:EnsemblMetazoa.
DR GO; GO:0005886; C:plasma membrane; IEA:EnsemblMetazoa.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005003; F:ephrin receptor activity; IEA:EnsemblMetazoa.
DR GO; GO:0019904; F:protein domain specific binding; IEA:EnsemblMetazoa.
DR GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IEA:EnsemblMetazoa.
DR GO; GO:0010172; P:embryonic body morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0016331; P:morphogenesis of embryonic epithelium; IEA:EnsemblMetazoa.
DR GO; GO:0001556; P:oocyte maturation; IEA:EnsemblMetazoa.
DR GO; GO:0018108; P:peptidyl-tyrosine phosphorylation; IEA:EnsemblMetazoa.
DR GO; GO:1902667; P:regulation of axon guidance; IEA:EnsemblMetazoa.
DR CDD; cd00063; FN3; 2.
DR CDD; cd05033; PTKc_EphR; 1.
DR Gene3D; 2.60.40.1770; ephrin a2 ectodomain; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR027936; Eph_TM.
DR InterPro; IPR001090; Ephrin_rcpt_lig-bd_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR016257; Tyr_kinase_ephrin_rcpt.
DR PANTHER; PTHR46877; EPH RECEPTOR A5; 1.
DR PANTHER; PTHR46877:SF14; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR Pfam; PF14575; EphA2_TM; 1.
DR Pfam; PF01404; Ephrin_lbd; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PIRSF; PIRSF000666; TyrPK_ephrin_receptor; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00615; EPH_lbd; 1.
DR SMART; SM01411; Ephrin_rec_like; 1.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51550; EPH_LBD; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRSR:PIRSR000666-
KW 2}; Disulfide bond {ECO:0000256|PIRSR:PIRSR000666-3};
KW Kinase {ECO:0000256|ARBA:ARBA00023137};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRSR:PIRSR000666-2}; Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Transferase {ECO:0000256|ARBA:ARBA00023137};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 546..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..202
FT /note="Eph LBD"
FT /evidence="ECO:0000259|PROSITE:PS51550"
FT DOMAIN 326..432
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 438..524
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 680..965
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1063..1099
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1063..1086
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 826
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000666-1"
FT BINDING 686..694
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000666-2"
FT BINDING 708
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT BINDING 730
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000666-2"
FT DISULFID 68..184
FT /evidence="ECO:0000256|PIRSR:PIRSR000666-3"
FT DISULFID 103..112
FT /evidence="ECO:0000256|PIRSR:PIRSR000666-3"
SQ SEQUENCE 1099 AA; 121939 MW; 37E9674B02A0445B CRC64;
MCSKYVDFYQ FFLSIPEVLF DLSKQPSDLK WDQVSLRHDR DDVWMEETWR NPAATDEKHA
NQRAYVTCNY DMINPSNWLF SHFIEVQSAR RVYIELLFNT RDCDAYLNPK SCKETFSVYL
KQFKTSRPGA TKIEKDRFEK DIDNWKNIGR LARSNSNMTT ETIGMEIEAD TKMIRIAFEE
QGICLSLLNV KIYYRICDEF TDQLVHFRPQ VTGPKETDMV RMNGTCIPNA SRKITGVDLI
GLCMSTGSGI KTSGECVCDS GYSQIADSNG ARCESCPPNT YKPKGQSLCK PCPVNSISGE
AASSCRCVNG YFRAEDELVS QPCSQPPSRP IKLVATAITA SSARLSWNEP SSLGGRPEIW
YEVRCSSSAR GECGSVVISP ADKRLSTRSV QINGLRPASD YTFLVFARNK VSSEIGGGAE
KSAVIDLRTR SEEEDVPPVS HLRVDASQSD GVTIAWSTAD SDVTDFEIEV RPAIVKPRAF
ETRHVNMTYS TFIGLRHDTV YQFRVRVKDD LRWSQSISYQ VGRGLVSSAP SEELGESQFL
NQTGSALLII IALILVVIAV ALCMIVVQKK SKNRKQMSDL DVLDTYKQDS MTPDYHTTSR
HHHQHGNVPA NLHEQLRSTT KLNAPLIPSF GSPISQPPPY YGGVHSGTSG KYKTYVDPTT
YEDPYQALIE FTFDISPNDV FITQVIGGGE FGDVCLGGLS RNSPAAAKWG ATVPRGGGGA
SEQYETVAIK TLKSGSSAKA KAEFLTEATI MGQFSHPNVI RLIGVVTSSE PVMIVAEYMA
NGSLDQFLRS ADQRGEKVAW EKITEMLYGI ASGMKYLTDM GYVHRDLAAR NVLLDQELRC
KIADFGLSRG VRSEGTSIEP EYTTNGGKIP VRWTAPEAIT HRKFTPSSDV WSFGVVIWEV
CSFGERPYWD WTNQKVISEV MIGYRLPPPM DCPMGLYRVA QWCWKMERHE RPTFTQLLAT
FHKYILQPAL IEQDLGELPR RVMSQATLGY GSVVPTPPSS AAPMPSLDDF LRQIGLNHVY
GKLVSNNIHS VSDLAATSHL DLLACGLISP ECSIVRDGLN GRISSGTTPP SSSSGSNGTI
HATTRGTRTT RPREEGFFV
//
