ID E3MT53_CAERE Unreviewed; 620 AA.
AC E3MT53;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=5' exonuclease Apollo {ECO:0000256|ARBA:ARBA00039555};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
DE AltName: Full=DNA cross-link repair 1B protein {ECO:0000256|ARBA:ARBA00041693};
DE AltName: Full=SNM1 homolog B {ECO:0000256|ARBA:ARBA00042738};
GN ORFNames=CRE_20424 {ECO:0000313|EMBL:EFP08628.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526};
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA repair metallo-beta-lactamase (DRMBL)
CC family. {ECO:0000256|ARBA:ARBA00010304}.
CC -!- SIMILARITY: Belongs to the telombin family.
CC {ECO:0000256|ARBA:ARBA00008442}.
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DR EMBL; DS268475; EFP08628.1; -; Genomic_DNA.
DR RefSeq; XP_003100657.1; XM_003100609.1.
DR AlphaFoldDB; E3MT53; -.
DR STRING; 31234.E3MT53; -.
DR EnsemblMetazoa; CRE20424.1; CRE20424.1; WBGene00085083.
DR eggNOG; KOG1361; Eukaryota.
DR HOGENOM; CLU_030379_0_0_1; -.
DR InParanoid; E3MT53; -.
DR OMA; CHIDKEM; -.
DR OrthoDB; 23465at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043047; F:single-stranded telomeric DNA binding; IEA:InterPro.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.12650; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR011084; DRMBL.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR032042; POT1PC.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR23240:SF8; 5' EXONUCLEASE APOLLO; 1.
DR PANTHER; PTHR23240; DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED; 1.
DR Pfam; PF07522; DRMBL; 1.
DR Pfam; PF16686; POT1PC; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Telomere {ECO:0000256|ARBA:ARBA00022895}.
FT DOMAIN 23..175
FT /note="Protection of telomeres protein 1 ssDNA-binding"
FT /evidence="ECO:0000259|Pfam:PF16686"
FT DOMAIN 435..503
FT /note="DNA repair metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF07522"
SQ SEQUENCE 620 AA; 71690 MW; 192E859A56CFAC53 CRC64;
MTMSLENRIR KGLEFDDDTY YSLSHVYTSL VAQVHSVVVT QKGFQYLRVW RARCFGPAKF
SEEREERIFR ITQEIFKSYL VPPDPRIGKA IEYFGKEYLL EIAVYDNHQE VLKTVNSGDF
ILLSNVHIGS KDKAITLSIH GGGFASYNRE ITPIPTDFSD PKMRLFRRRC RRMLEQVTDY
ENFEEFIEHE ELEDENDNLV AEPYKNIMIG DEIAVNYFPK SFPCSYHFLT HIHPEYLRDL
DLTADRTVFC SETTSDILPE IMGIDSKNVP ANSIFPMRLN HPYSFEEFQA TMIDSNHCPG
SVMILFEGEL IQKHAGGPVL CTGDFRADKT FLSELKSGPC RFLSELKLAR IYMDNTYFSL
DQNILQLDHA RDLLIQNIES RYPDKNIIIP LHRLGRESLI ESIVQALNEP ILMFKERLEI
ARILNAEHPA VRKNTIRNIE IVEKDTWDYS VPENSVVINI SMNDCIVESQ QEKVINIRYS
NHSSRYEILN FLNELHFDSI YPCAKKFSKN EMRLMLEAGK KQYKEDDLDR QLNIHEFVTT
DDQGTSESLE VVAANPDFQE TSKSLEVAEI EMKGSLATKP PNLLAETSDT GFCEESGSVQ
MEPPRKKGKF QNLQEKIMHI
//
