ID E3MV07_CAERE Unreviewed; 691 AA.
AC E3MV07;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=CRE-DEL-1 protein {ECO:0000313|EMBL:EFP09968.1};
GN Name=Cre-del-1 {ECO:0000313|EMBL:EFP09968.1};
GN ORFNames=CRE_20869 {ECO:0000313|EMBL:EFP09968.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC ECO:0000256|RuleBase:RU000679}.
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DR EMBL; DS268481; EFP09968.1; -; Genomic_DNA.
DR RefSeq; XP_003099963.1; XM_003099915.1.
DR AlphaFoldDB; E3MV07; -.
DR STRING; 31234.E3MV07; -.
DR EnsemblMetazoa; CRE20869.1; CRE20869.1; WBGene00066166.
DR eggNOG; KOG4294; Eukaryota.
DR HOGENOM; CLU_017673_0_0_1; -.
DR InParanoid; E3MV07; -.
DR OMA; NACICNY; -.
DR OrthoDB; 5344287at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR004726; Deg-1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR020903; ENaC_CS.
DR NCBIfam; TIGR00867; deg-1; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR PANTHER; PTHR11690:SF300; DEGENERIN DEL-1; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 93..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 635..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 47..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 691 AA; 78904 MW; DD1EC18DEBC8F51D CRC64;
MPFGVMGNRK NLVHRILTPR LLRRNEEKYR ETEALVKKYK QQKECDVGKP FADDSPRKED
EEGTGEQIQH SVRVFCEQTT FHGVNMIFTT ALYWVRLLWI IVSFACIGLC LYSFSHIKAK
YDRREKIVNV ELQFESAPFP AITVCNLNPF KNHLARSVPE ISETLDAFHQ AVVYSNDATM
DELNGRGKRS LNDGPSFKYL QYEPVYSDCL CVAEKQECIA QTTIPKSLEN ACICNYDRQD
GSAWPCYSAQ TWEKSICPEC NDIGFCNVPN TTGNGNIPCY CQLAMGYCVF MPESRVRRVW
EFQGNKIPEK GSPLRREYLE QLTQLGYGNM TDQVAITTQA KEKMILKMSG LHPQRRAALG
YGKSELIKMC SFDGQQCNIE TEFKLFIDSS FGNCYTFNFD PKKNLTSSRA GPSYGLRLML
FVNTSDYLPT TEATGVRLAI HDKTECPFPD TFGYSAPVGA ISSFGISLRK VNRLPDGNCY
NEDRPPHNYI YKEYKYEPEG CLRTCYQRRI ILRCGCADPR FPNPWRRSPW CDSKNSTILT
CLTVEGAKLS SSFKHQCKCS HPCQQDQYTT TYSAAKWPSG STQAHCDNQS KDCNRYLREH
AAMIEIYYEQ MSFEVLRESE SYSWFNLMAD MGGQAGLFLG ASIMSVIEFL FFAVRTLGIA
CKSRRWKQKN ELLRAEELND AEKGTSTNNN A
//
