ID E3N013_CAERE Unreviewed; 1196 AA.
AC E3N013;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Tyrosine-protein phosphatase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CRE_08462 {ECO:0000313|EMBL:EFP13211.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DS268503; EFP13211.1; -; Genomic_DNA.
DR RefSeq; XP_003098272.1; XM_003098224.1.
DR AlphaFoldDB; E3N013; -.
DR STRING; 31234.E3N013; -.
DR EnsemblMetazoa; CRE08462.1; CRE08462.1; WBGene00066662.
DR eggNOG; ENOG502SCJ0; Eukaryota.
DR HOGENOM; CLU_003480_1_0_1; -.
DR InParanoid; E3N013; -.
DR OrthoDB; 2891484at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR003125; WSN.
DR PANTHER; PTHR32525; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR PANTHER; PTHR32525:SF4; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF02206; WSN; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SMART; SM00453; WSN; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..1196
FT /note="Tyrosine-protein phosphatase domain-containing
FT protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012700375"
FT TRANSMEM 843..863
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 920..1079
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1001..1070
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 805..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1140..1196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 805..822
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1196 AA; 134297 MW; F1512A99C0E29C87 CRC64;
MNLLIILITA ILANAVPIIR DLPHEPNIPP NGDSNLSEDV LHRTSNPSEI RERFYRASDP
ILDSHVFNLK MVARITNGIY LIQGITSGTI DSDELISELL RFGPVKSSDI SAIDMSKVKS
AISDMKKLSE KLVATDEVKD VEKVFDVLKE VLAAVDGIGN LTEWTDEKEY FKSEIGRLAK
DGLDLTDIDS LDTAYKTWKP LYKQLSEKKP ATSADDVENV KKSLQNLKTA TTNLRNPGSI
WQFTNFTFVA DGIAPILKAE HGVDIFLAQS QYMTIQDSQR QVYTTYANPI PGILNDLVSR
FADIQLVSKL GTSRREVKKR QLRHTFGLSD SPSDLSSISS DLADSWIKKV IKTEQMKTAL
KQLEGLAVLS KNVDTSLGGN LGGIDDLVAI LKSLDDVSKE VTASESGVSL RFNCTIVTAS
NIKKDAFKTL NDSLADIDDK LVKLKTATDN LLQYVDTSGV IKLSDEVIAV CEKMKTDKSD
YQEIWTELGT YNNLKELNGK LEKIYVLLTA INGLLTINGD AANAMKLMDS LDGYHNRLLH
YSDYFKCLQD QDQLKLVFKT IDGLNRIRGW KDDTTYSKTL TDGLNIVQKV VDAKSGLEKM
KTSIKELSEL KTPETDAMKD LPEAATHSEV IGKAVQGLAG MADALKQEDD LKKVVNNIDL
VETGKQKTTN PKDVESLNEL VKLSKDITPM LKSLTTFSTS LSEFSKSDSL AVQSDIFSSA
KQVSGVTGTF SSMVKAVGEL KKISSPPDAA ELTKVEEGLK TMDTLDLNFA GFHQSFDDSK
KSLTALDLFF AKTWKKFQPT TPIPAQRPTL GLETSTGDVV GSGAQSAAEK DEEKKEDNDD
LKYAGGIVAF LVVTLAIVFF LLYKFQRPWL MKRLPCLCWK KEKKKEKQED EKPSEPPLPP
EPPLIGPILP PIGYFFKLFV VPIFEQFEVM KTKKFLDTIN VDYMLYEYLE VRHDDARVKA
FDEEIFDTEW TECLKEPPFT ATHYHYTGWL RGTYPANLGP LKKIFRRLAT DSTPAIIHCS
DGQERTGMFA LAGLMKHRIK MSMNELDIQQ CMFDVMSTRV NALQDHQDVA YSVHLCMELL
ADNEILPAVL HIDYDKMKGA WDRYLVESDK RGVKKGLLLL EEVFSDNSVD EDRSRKYKIK
KPPTVEEKKE DLLHKMREKN ERKKAEVGRR EDAIKEERQK KWDEEQAAKK LKETKK
//
