ID E3N1N3_CAERE Unreviewed; 539 AA.
AC E3N1N3;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Methionine--tRNA ligase, mitochondrial {ECO:0000256|ARBA:ARBA00026124};
DE EC=6.1.1.10 {ECO:0000256|ARBA:ARBA00012838};
DE EC=6.1.1.4 {ECO:0000256|ARBA:ARBA00013164};
DE AltName: Full=Mitochondrial methionyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030331};
GN ORFNames=CRE_14236 {ECO:0000313|EMBL:EFO83774.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|RuleBase:RU363039}.
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DR EMBL; DS268509; EFO83774.1; -; Genomic_DNA.
DR RefSeq; XP_003097704.1; XM_003097656.1.
DR AlphaFoldDB; E3N1N3; -.
DR STRING; 31234.E3N1N3; -.
DR EnsemblMetazoa; CRE14236.1; CRE14236.1; WBGene00060840.
DR eggNOG; KOG0436; Eukaryota.
DR HOGENOM; CLU_009710_9_0_1; -.
DR InParanoid; E3N1N3; -.
DR OMA; NMFLPDR; -.
DR OrthoDB; 166496at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004825; F:methionine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006431; P:methionyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07957; Anticodon_Ia_Met; 1.
DR Gene3D; 2.170.220.10; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR041872; Anticodon_Met.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014758; Met-tRNA_synth.
DR InterPro; IPR023457; Met-tRNA_synth_2.
DR InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR InterPro; IPR033911; MetRS_core.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR NCBIfam; TIGR00398; metG; 1.
DR PANTHER; PTHR43326:SF1; METHIONINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43326; METHIONYL-TRNA SYNTHETASE; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF09334; tRNA-synt_1g; 1.
DR PRINTS; PR01041; TRNASYNTHMET.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363039};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363039};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363039};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281}.
FT DOMAIN 38..391
FT /note="Methionyl/Leucyl tRNA synthetase"
FT /evidence="ECO:0000259|Pfam:PF09334"
FT DOMAIN 421..502
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
FT COILED 405..433
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 539 AA; 62107 MW; 4AA50F267975A727 CRC64;
MIRSRCLIRN SHTFVTSPIF YANAGKVRSG YFATFPNLFS ISEPHIGHAY TAVLCDTAYR
WNVLKNSNNQ NSDSRALFSI GTDEHGSKIY QASQLAKKTP KEFCDQVSSK FSNLFENLNL
SHTHFIRTTD SKHSEAVQTF WKTLSSNGYI YKSSYSGYYS ITDECFIPEN EVEKRNDKMV
LKTTSQPVEW IEEENYMFRL SEFREKVKEW IEKTDVVYPV KYKTLALDSL TMEDDLSISR
TRSRLSWGIP VPDDPSQTIY VWLDALVNYL TVSGYPQKQF VWPPTCQIIG KDITKFHLFY
WPAFLMAANL SLPKKVFIHG HWLVDNVKMS KSLGNVVNPN ETMDKFTSEG LRYFLLKQGN
PSSDCSFSWS SCLEMINSDM VNNVGNLVNR STVAKINKSG EYPKVESLES KVKEDTEKLM
EMLEESYEKC IELYNEMMYY KVIEHLMLIM KEANRVFQLS QPWKETNSER LESVLYVTYE
TIRVVSILLQ PITPKMAAFC LDRLGVKAEK RGLADAKIGC YSGGKLGKDR GVFIERIQK
//
