ID E3N7Q9_CAERE Unreviewed; 979 AA.
AC E3N7Q9;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=CRE-DRH-3 protein {ECO:0000313|EMBL:EFO89112.1};
GN Name=Cre-drh-3 {ECO:0000313|EMBL:EFO89112.1};
GN ORFNames=CRE_14916 {ECO:0000313|EMBL:EFO89112.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00029316};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00029316};
CC -!- SIMILARITY: Belongs to the helicase family. RLR subfamily.
CC {ECO:0000256|ARBA:ARBA00006866}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS268550; EFO89112.1; -; Genomic_DNA.
DR RefSeq; XP_003095565.1; XM_003095517.1.
DR AlphaFoldDB; E3N7Q9; -.
DR STRING; 31234.E3N7Q9; -.
DR EnsemblMetazoa; CRE14916.1; CRE14916.1; WBGene00070866.
DR eggNOG; KOG0354; Eukaryota.
DR HOGENOM; CLU_297035_0_0_1; -.
DR InParanoid; E3N7Q9; -.
DR OMA; SSMRIAC; -.
DR OrthoDB; 342391at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0000794; C:condensed nuclear chromosome; IEA:EnsemblMetazoa.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0070090; C:metaphase plate; IEA:EnsemblMetazoa.
DR GO; GO:0043186; C:P granule; IEA:EnsemblMetazoa.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:EnsemblMetazoa.
DR GO; GO:0008186; F:ATP-dependent activity, acting on RNA; IEA:EnsemblMetazoa.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:EnsemblMetazoa.
DR GO; GO:0070063; F:RNA polymerase binding; IEA:EnsemblMetazoa.
DR GO; GO:0003727; F:single-stranded RNA binding; IEA:EnsemblMetazoa.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:1903863; P:P granule assembly; IEA:EnsemblMetazoa.
DR GO; GO:0035194; P:regulatory ncRNA-mediated post-transcriptional gene silencing; IEA:EnsemblMetazoa.
DR GO; GO:0030422; P:siRNA processing; IEA:EnsemblMetazoa.
DR CDD; cd15804; RLR_C; 1.
DR Gene3D; 1.20.1320.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 2.170.150.30; RIG-I-like receptor, C-terminal regulatory domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038557; RLR_C_sf.
DR InterPro; IPR021673; RLR_CTR.
DR PANTHER; PTHR14074:SF16; ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I; 1.
DR PANTHER; PTHR14074; HELICASE WITH DEATH DOMAIN-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF11648; RIG-I_C-RD; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51789; RLR_CTR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 35..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 217..396
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 582..760
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 775..905
FT /note="RLR CTR"
FT /evidence="ECO:0000259|PROSITE:PS51789"
FT REGION 947..979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 749..781
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 947..963
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 979 AA; 112362 MW; 1A881F5E956B9653 CRC64;
MSLLIHVSTT IRRILAYFVL FNVGLGLLGL PWFSIYIGLS GLCLCFFTCF HVYKKNDRMM
FPFYLYVLFT IFYLLFLGGY FFFVNIFHKE MVKGRDFSHL QVTTLILFLT IPGFDMKHRK
PEDRDEWYYG LLDAMRHDAA NRSALHFLNS KYSEELEERD KERDRLRLQV LKGQQVNEEA
VGEQIFQTIR PQPKDNGFIP SLEAGELVLR TYQEELVQTA LEGKNCVIIA PTGSGKTEVA
IYAAMKHISR REAFGEHSRV VLVVPKIPLV TQQKERFLKY CNGKYVVNGF HGSEKSDSGE
GRRDDVLASH IVVMTPQILI NMLQSVRRNE RLYVSDFSMM IFDEVHYTTG NHAYVNLNRI
VQEWEYDKPQ IIGLTASLNV NASQQTDINS MLNGIYSMLA LLNAPHLSTI THQSSIDELN
KYVSKPDDTI EVVQPGENVL RSHIDNYLNT KHYKLVAELE KLSKSRHNCF PAGSFRSFKN
AKPKEFMLYE SLVQSLIQDL NKLNTPDKMV AQKWTKYIRV YIEARGIVDV MPAMVAFNFM
EESIRQLNSE HTLDQFSDFL TDKVYDPLKQ RSEGVEPEIV KKLKTTLVNQ FKEQPDSRVI
IFVTQRNTAQ RVSEFLNESG ILEQFLNTTT RQKTVGYVLG TNNTGSVQQS PQEQQRVLEQ
FNSGKLKVIV ATSVVEEGLD VTSCNLIIKY NCSSASAIQL VQRRGRARAK NSRSVLLAVH
SRVQNDESNA MLSEKFMRQC VKIIEQNGNK MLEKEVHKAT VDIQRQRAAE AAELKQQMER
NGRNIFTVNC AQCQWTFCKS TDIKKVSSNY MAFHPMVWDN VSVESQKKAP SYRNEDTQPL
SILKCHKCQH LVGKAYKMRG VYLPQFAVKN VNFVAQNNDN GTATKAHWSG VQDELFFIGE
ATQHDFEIML NALGNTEANM DKKRILDLDS KQLMKLVESK RFLAMKEKKE QEARMKRAED
EENGVVPTNG STEFSEDED
//
