ID   E3N9D0_CAERE            Unreviewed;      1368 AA.
AC   E3N9D0;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   24-JAN-2024, entry version 49.
DE   RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   ORFNames=CRE_23046 {ECO:0000313|EMBL:EFO90256.1};
OS   Caenorhabditis remanei (Caenorhabditis vulgaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN   [1] {ECO:0000313|Proteomes:UP000008281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG   Caenorhabditis remanei Sequencing Consortium;
RA   Wilson R.K.;
RT   "PCAP assembly of the Caenorhabditis remanei genome.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR   EMBL; DS268565; EFO90256.1; -; Genomic_DNA.
DR   RefSeq; XP_003094939.1; XM_003094891.1.
DR   STRING; 31234.E3N9D0; -.
DR   EnsemblMetazoa; CRE23046.1; CRE23046.1; WBGene00069606.
DR   eggNOG; ENOG502QQ9V; Eukaryota.
DR   HOGENOM; CLU_001474_0_0_1; -.
DR   InParanoid; E3N9D0; -.
DR   OrthoDB; 5472322at2759; -.
DR   Proteomes; UP000008281; Unassembled WGS sequence.
DR   GO; GO:0042575; C:DNA polymerase complex; IEA:UniProt.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   Gene3D; 3.40.960.10; VSR Endonuclease; 1.
DR   InterPro; IPR004868; DNA-dir_DNA_pol_B_mt/vir.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR33568; DNA POLYMERASE; 1.
DR   PANTHER; PTHR33568:SF3; DNA-DIRECTED DNA POLYMERASE; 1.
DR   Pfam; PF03175; DNA_pol_B_2; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   4: Predicted;
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          548..1066
FT                   /note="DNA-directed DNA polymerase family B
FT                   mitochondria/virus"
FT                   /evidence="ECO:0000259|Pfam:PF03175"
SQ   SEQUENCE   1368 AA;  159121 MW;  47336D4E96969E3B CRC64;
     MEKWNTPGAI EETIEEVCAK VKLVTGSGRK PIKPLHQVAV EFENKDGTQF MDEEEIIEMK
     NHIHFEYEPK FVYRNEKRVS LPETRLRFKG KTNSPELMER TFDQFIRYCI GKAGGNLERS
     KMSFGFFHEG FHKAEGFWIN ERTYQTFNGQ VLMEELVRIT QSKAEVDIDD TFIIHMHVFN
     NFEGGAGRCR KKMFDEQKKL PAYVVGDGKC LPKAVALAMT FYASKEDAEQ RSKWDRMIRL
     MYRSLNEKLQ LAAANEILEK SGLSTEQQVF NIDDLEKIAA TYPEYKFEVY SRPAYEKYYQ
     IITEFNFDAS KLVTIAFKKI DGVGHYDFIK PSLMHMKATY CHKCKQKTLS TGHNQVCDAK
     CGKCGFYECD NTQIETIHCE MCNTNFPNED CYNGHLEYAY RAKKTMCEKR YTCLECGFRV
     CKDKVSQDEV HECEKRSRCM QCKEMYDATR YHNCCFQPPR KRFKESKMKA QKSYRILCYD
     VETIVVNSAN GPDFSKPQPN HEVNLVCFKM CCNLCVEEGM ECDCETGNFH YFEHVDPLED
     FVDFLLHNTK LDNAYVIAHN GGRYDHNFVL SRIMTSFGII PDYVSNGTSL IMANITASVR
     RTDTHNSLKF RDSFRFIPMP LSKMPKTFGI TELKKGYYPY YFNHKENYGK VLNRLPDKLF
     YDPEHMKPEP RIEFEKWYED HQNDVFDADM EILVYCQSDV EILTSGLSEY IKICKRLFNN
     WNPIIYSCTI ASYVHHILKF EHFQQGDLGI ISENGWPERN NSVFALKTLM WLEKKDGVTI
     HHKLRGPEKM IKMPNGDCFF VDGYEEKSNT VYEIYGCFYH GCPMCTNPTL EHPNHPGVEN
     KAIYDRTMKR EERIKEAEYN VISWWEHEIN EMLKKDSEMR DFFKKCRHAS HLVPREGMFG
     GRTQPYQMIV ECEEDEEICY DDFNSLYPSV NIMFQYPRGQ PIVYKTNFPS IIPGKGVDKK
     GLYFCSIYAP PAIKITVLPY KIPGFLTFPS CRTCIEKNQK TACNHTKVSD RYLTGVWTHA
     ELNAAIERGY QLLQFHEIWW WPDDKWKTAD YFVNYLKSMI QLKHESSGWP KDGMTDEEKL
     AYINEIAQRD GVTLVMENVK KADNMREMSK LFLNTCWGKL AENPVRTESK LFETLDHVSQ
     SEYMSKQGYE VKGIKDWDDG RTLITRASKT ESVKTKEFTS IVIGIYTTSY ARLRLLQAME
     AVGSENLIYV DTDSVIYKKK ISDPCPVKAL IGDGLGKLKS EIPKGYQMKK IICMASKVYS
     YLLKHLETGE EKIVTKFKGV VLNSSTSRTI NMKTMEASVR EFLDGQTNVI SVPERTMRRT
     KVLGEITTAP FEKRLKPVMD KVRVLPGGKT LPSGYYLNCP LVEDYPYS
//