ID E3NAT2_CAERE Unreviewed; 460 AA.
AC E3NAT2;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=CRE-TTX-3 protein {ECO:0000313|EMBL:EFO91271.1};
GN Name=Cre-ttx-3 {ECO:0000313|EMBL:EFO91271.1};
GN ORFNames=CRE_04300 {ECO:0000313|EMBL:EFO91271.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR EMBL; DS268578; EFO91271.1; -; Genomic_DNA.
DR RefSeq; XP_003094518.1; XM_003094470.1.
DR AlphaFoldDB; E3NAT2; -.
DR STRING; 31234.E3NAT2; -.
DR EnsemblMetazoa; CRE04300.1; CRE04300.1; WBGene00051043.
DR GeneID; 9804473; -.
DR KEGG; crq:GCK72_025105; -.
DR CTD; 9804473; -.
DR eggNOG; KOG0490; Eukaryota.
DR HOGENOM; CLU_726129_0_0_1; -.
DR InParanoid; E3NAT2; -.
DR OMA; LYCHAHY; -.
DR OrthoDB; 2880952at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:EnsemblMetazoa.
DR GO; GO:0007409; P:axonogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0040024; P:dauer larval development; IEA:EnsemblMetazoa.
DR GO; GO:0022401; P:negative adaptation of signaling pathway; IEA:EnsemblMetazoa.
DR GO; GO:0008355; P:olfactory learning; IEA:EnsemblMetazoa.
DR GO; GO:0061066; P:positive regulation of dauer larval development; IEA:EnsemblMetazoa.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
DR GO; GO:0030516; P:regulation of axon extension; IEA:EnsemblMetazoa.
DR GO; GO:1902667; P:regulation of axon guidance; IEA:EnsemblMetazoa.
DR GO; GO:0045664; P:regulation of neuron differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0040040; P:thermosensory behavior; IEA:EnsemblMetazoa.
DR GO; GO:0043052; P:thermotaxis; IEA:EnsemblMetazoa.
DR CDD; cd00086; homeodomain; 1.
DR CDD; cd08368; LIM; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24208; LIM/HOMEOBOX PROTEIN LHX; 1.
DR PANTHER; PTHR24208:SF168; PROTEIN APTEROUS; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00132; LIM; 2.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 159..220
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 222..283
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 346..406
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 348..407
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 297..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..314
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 460 AA; 52194 MW; 2DBDBA9ADA6982AF CRC64;
MSCSQPKVEN IERMGDLIGL ILQYSDPKSL SEFMELSAIH TVELYLKSLI LPYFAYWLPP
MDTHSIDKSE SIYQILRFYL MLTNSATKEI LTTHVVPETA LFQFTWGTKF REEYELVERI
SSPQYVNLTS TSPSSTSSDP KLSILQQIQV PEPKSVVINQ CAHCHFAIYD KDISVLDDKN
YHHNCIRCSM CDAPFEYTEK CYVHDGVVYC HDDHAKRYRK CCRKCELPLK REDMIMKAKE
MIFHHACFVC FICGTKLNTG DYYTMSPSGH LYCHAHYDVI RTSALCDEPT PPVVVAAPLS
PPKTTPPPVV KKEATPAPPA AEKPAREPST EGEASTDEDG SNGSNQRSKR MRTSFKHHQL
RAMKTYFALN HNPDAKDLKQ LAAKTNLTKR VLQVWFQNAR AKYRRGLQDG GRSSPLCIAG
ALSTMDMNPP LSIRSTDVYQ LNTPPLSTEV YSPNNNYTHL
//
