ID E3NB73_CAERE Unreviewed; 416 AA.
AC E3NB73;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=CRE-NHR-70 protein {ECO:0000313|EMBL:EFO91792.1};
GN Name=Cre-nhr-70 {ECO:0000313|EMBL:EFO91792.1};
GN ORFNames=CRE_07801 {ECO:0000313|EMBL:EFO91792.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000256|ARBA:ARBA00005993, ECO:0000256|RuleBase:RU004334}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS268582; EFO91792.1; -; Genomic_DNA.
DR RefSeq; XP_003094338.1; XM_003094290.1.
DR AlphaFoldDB; E3NB73; -.
DR STRING; 31234.E3NB73; -.
DR EnsemblMetazoa; CRE07801.1; CRE07801.1; WBGene00069819.
DR GeneID; 9812706; -.
DR KEGG; crq:GCK72_022047; -.
DR CTD; 9812706; -.
DR eggNOG; KOG3575; Eukaryota.
DR HOGENOM; CLU_007368_1_1_1; -.
DR InParanoid; E3NB73; -.
DR OMA; YEMCNGR; -.
DR OrthoDB; 2880173at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06960; NR_DBD_HNF4A; 1.
DR CDD; cd06157; NR_LBD; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR049636; HNF4-like_DBD.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR46011:SF32; NUCLEAR HORMONE RECEPTOR FAMILY; 1.
DR PANTHER; PTHR46011; NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-86-RELATED; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 43..118
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 168..415
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
SQ SEQUENCE 416 AA; 46911 MW; FB651EB0345B043E CRC64;
MNFQLNNADI GNGMPLRDGY TGSDASSPNL LSSNKPMNSK GDKPPCSICG EVGNGIHFGA
EACRACAAFF RRSVALNKLY RCRGNGHCDI LSTIRCMCRA CRFTKCIQVG MKREAVQKYR
DAYGKRGSDV ESPSTSVPIG MGFSSSQNTT LESVEEGGMP ILSTLSANYA KLESVRRVVH
QESGTSVFQK RTPKAVTYKE ANEVSSKECD LVADWILNSY PGFSDLPKEQ KKILFRNFFL
PFVILQGGHF ACTHNRNDVI ILASGDFIDC SHPETFYYDP DGRQLMSSED AVRMFASSFS
NYRRNVTDPM LRDNVDSYEF FALCSLVLFD TGLEGQSEEC IIVARRIREA IQREILYYYR
NVRHIEDPSM RLANLLSLLP ALQRATRRFQ EDVEISHVFN VYSVDEKFYE MCNGRF
//
