ID E3NMH7_CAERE Unreviewed; 557 AA.
AC E3NMH7;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=EF-hand domain-containing protein {ECO:0000259|PROSITE:PS50222};
GN ORFNames=CRE_23209 {ECO:0000313|EMBL:EFP08090.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion intermembrane
CC space {ECO:0000256|ARBA:ARBA00004569}.
CC -!- SIMILARITY: Belongs to the MICU1 family. MICU1 subfamily.
CC {ECO:0000256|ARBA:ARBA00038333}.
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DR EMBL; DS269045; EFP08090.1; -; Genomic_DNA.
DR RefSeq; XP_003090397.1; XM_003090349.1.
DR AlphaFoldDB; E3NMH7; -.
DR STRING; 31234.E3NMH7; -.
DR EnsemblMetazoa; CRE23209.1; CRE23209.1; WBGene00073894.
DR eggNOG; KOG2643; Eukaryota.
DR HOGENOM; CLU_027103_3_0_1; -.
DR InParanoid; E3NMH7; -.
DR OMA; TTVGMKH; -.
DR OrthoDB; 1020411at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006851; P:mitochondrial calcium ion transmembrane transport; IEA:InterPro.
DR CDD; cd15900; EFh_MICU; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR039800; MICU1/2/3.
DR PANTHER; PTHR12294:SF1; CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12294; EF HAND DOMAIN FAMILY A1,A2-RELATED; 1.
DR Pfam; PF13202; EF-hand_5; 1.
DR Pfam; PF13833; EF-hand_8; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 2.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00022792};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00022792};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 294..329
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 489..524
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 557 AA; 65185 MW; 19CE7D333B2937D2 CRC64;
MLRLQFSRSI RIQKKIAKQF VIVRSCASSP TKTNVSAKQQ DSLKNIDPGE NYTALGNLRQ
KKDVFHYTDR FYFRASGTGY SHYSNSVYQH RPYIWPPLRK LYNWNYALVI AGMVILMSDF
EWFVLKVSTY HEVAYFRLKE QIKGASAPFR PQASQIEEQK ESISEIEVVK EKPKKKKLGF
RERRIIEYED RLRLYSTPDK IFRYFATLKI IDPNDESGRI FEVFMTPEDF LRSFTPGVMQ
PRRWGLDSFK AYNPEKHKRH KFSDPNSIFY KLGENGLINF SDYLTWLVIR FFTASHADFA
LAFKIFDVDG NGALDKEEFT KVQQLIMSQT TVGQRHRDHV TPNSSFRVET NSALETYFFG
KDGKGSLSSE KFIEFQERLQ HDILKMEFER RDAMDSLDGL ITEESFAQLL LLHAQIAEKK
QKHMLKRVKR RFKGEESKGV SFEETKAFFE FLYHIDDVDI ALHFHKMAGM SIDAKLLKRV
AVKVTGIPLS DHVVDVVITL FDDNLDGKLS HEEMVAVMRR RMRRGLERPR DTGLFRLFDA
VLECSKRAYH ASPLPFY
//
