ID E3NPM5_CAERE Unreviewed; 685 AA.
AC E3NPM5;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE RecName: Full=Potassium channel domain-containing protein {ECO:0000259|Pfam:PF07885};
GN ORFNames=CRE_17734 {ECO:0000313|EMBL:EFP13455.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
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DR EMBL; DS269397; EFP13455.1; -; Genomic_DNA.
DR RefSeq; XP_003089644.1; XM_003089596.1.
DR AlphaFoldDB; E3NPM5; -.
DR STRING; 31234.E3NPM5; -.
DR EnsemblMetazoa; CRE17734.1; CRE17734.1; WBGene00073777.
DR eggNOG; KOG1418; Eukaryota.
DR HOGENOM; CLU_028432_0_0_1; -.
DR InParanoid; E3NPM5; -.
DR OMA; NDICSDE; -.
DR OrthoDB; 2882865at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR PANTHER; PTHR11003:SF317; PROTEIN CBR-EGL-23; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|RuleBase:RU003857};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 168..229
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 308..382
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 467..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 116..173
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 475..503
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..552
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..578
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..608
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..685
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 685 AA; 76388 MW; AD07FF0FA3C29186 CRC64;
MKKCLIFQAT PLFVHFLMIV SVGAYAIFGA LVMRSLESNT ITTIEKKTDV HRRHLNLSNS
VEIQNVPPIP SELRHRRRRR HNDTLDQFSE KMSREKRAAA HIMRSRKCVI SVIKKMSSLE
CSMDTLDEKL VKALDECYHV AVEHNTHVNH VLYENSKEEV ESVGEESEEE IAEWSFMDSL
LFAFTVITTI GYGNVAPRTF GGRLFVIGYG LIGIPFTLLA IADLGKFISE MMVVAKTFCK
KTWKKLKKAW NPNFIRYPKL SGAKDLSNTD IEEKILENEK IENEIESSET SEEEDDLTET
EATSLFILFL LYIAFGGMML AAYEPDMDFF KAVYFNFVTL TSIGLGDIVP RSETYMLITI
VYIAIGLALT TIAIEIAADA LKKLHYFGRK IENVGNVAIW FGGKKITMKA LVKNLGDQFN
LPTTVVKSLN LDHFVDQAIK VEEGEIETLR PPPFEPDSER FDAEFADEPE SEWIRDPTPT
PPPSPQPVYR LPSPKPKTPS PLPSPSITDK SMAIATPSPE ESEDDEELIL PSPEPSPIRE
PTPSPPPREP TPREPTPEPE PYREPTPPPP PPPKPRPLTA AEIAAQKRKA YSEEAWRQYQ
EYQKQWKKFR QTQKTPAPGA STSGASTSKQ SGASPEGGGQ TGTGPSTRSQ SVTSVASGKT
SRSATPESKK SSHPSSSSRR ESGAK
//
