ID   E3NRU2_CAERE            Unreviewed;       612 AA.
AC   E3NRU2;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   RecName: Full=Proline dehydrogenase {ECO:0000256|RuleBase:RU364054};
DE            EC=1.5.5.2 {ECO:0000256|RuleBase:RU364054};
GN   ORFNames=CRE_02755 {ECO:0000313|EMBL:EFO88479.1};
OS   Caenorhabditis remanei (Caenorhabditis vulgaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN   [1] {ECO:0000313|Proteomes:UP000008281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG   Caenorhabditis remanei Sequencing Consortium;
RA   Wilson R.K.;
RT   "PCAP assembly of the Caenorhabditis remanei genome.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Converts proline to delta-1-pyrroline-5-carboxylate.
CC       {ECO:0000256|RuleBase:RU364054}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a
CC         quinol + H(+); Xref=Rhea:RHEA:23784, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17388, ChEBI:CHEBI:24646, ChEBI:CHEBI:60039,
CC         ChEBI:CHEBI:132124; EC=1.5.5.2;
CC         Evidence={ECO:0000256|RuleBase:RU364054};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|RuleBase:RU364054};
CC   -!- PATHWAY: Amino-acid degradation; L-proline degradation into L-
CC       glutamate; L-glutamate from L-proline: step 1/2.
CC       {ECO:0000256|ARBA:ARBA00004739}.
CC   -!- SIMILARITY: Belongs to the proline oxidase family.
CC       {ECO:0000256|ARBA:ARBA00005869, ECO:0000256|RuleBase:RU364054}.
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DR   EMBL; DS269805; EFO88479.1; -; Genomic_DNA.
DR   RefSeq; XP_003088879.1; XM_003088831.1.
DR   AlphaFoldDB; E3NRU2; -.
DR   STRING; 31234.E3NRU2; -.
DR   EnsemblMetazoa; CRE02755.1; CRE02755.1; WBGene00079398.
DR   eggNOG; KOG0186; Eukaryota.
DR   HOGENOM; CLU_018202_3_1_1; -.
DR   InParanoid; E3NRU2; -.
DR   OMA; YEICSRA; -.
DR   OrthoDB; 5473051at2759; -.
DR   Proteomes; UP000008281; Unassembled WGS sequence.
DR   GO; GO:0004657; F:proline dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006562; P:proline catabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.220; -; 2.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR   InterPro; IPR002872; Proline_DH_dom.
DR   InterPro; IPR015659; Proline_oxidase.
DR   PANTHER; PTHR13914:SF0; PROLINE DEHYDROGENASE 1, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR13914; PROLINE OXIDASE; 1.
DR   Pfam; PF01619; Pro_dh; 1.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|RuleBase:RU364054};
KW   Flavoprotein {ECO:0000256|RuleBase:RU364054};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU364054};
KW   Proline metabolism {ECO:0000256|ARBA:ARBA00023062,
KW   ECO:0000256|RuleBase:RU364054};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008281}.
FT   DOMAIN          204..587
FT                   /note="Proline dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF01619"
SQ   SEQUENCE   612 AA;  69311 MW;  FEA5AB9553C3C84B CRC64;
     MQSALIGLNF PLQRRFLSGV LTSTSSATRC YSSDVKKYEC TSAEHKKELD ECYNRLDLSF
     ENTKEAFKSK SNTELVRALV VLRLCGVQTL VNQNQMILAT MRRVLGKNLF KKTLKNTFYG
     HFVAGETEEE VRPVVGKLRN YGVKSILDYS VEADISGQEA TDKTVKGTSQ ATVKPAAMTP
     VVDAKTLETT RERYTVHQEF GDRRQGVASA RTYFYEGEEQ CNKNRDIFKD SINAVASATG
     NEGFVAVKVT ALGRPQLLLK LSEAIVQTQN FFKALTGGMT LQEGRLTSQE FTKRLHELGV
     KTDSESVKKF FNDVDFDSDG IVDLHGWNHI LDDHVKLGQL FQVLNIKTGA LEPLIQNLSN
     EEEQEFRNMV RRTLDVAEYA ISKGVRIMVD AEQTYLQPAI SKITIEMMKK YNKDRGNVFN
     TYQAYLKATL QNMEADMQVA RREGWHFGAK LVRGAYMEQE RARAQAIGYD DPVNVDFQAT
     TKMYESCLTR IADEVDRRGR TNVSVMVASH NEDTVRFAVN LMKERCIAPS ERVMCMAQLY
     GMCDQVSFSL GQAGFSVYKY LPYGPVEEVL PYLSRRALEN GSVLKKANKE RDLLWKELKR
     RISSGEFKAK HN
//