ID   E3NUJ8_CAERE            Unreviewed;       801 AA.
AC   E3NUJ8;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=CRE_05360 {ECO:0000313|EMBL:EFO95669.1};
OS   Caenorhabditis remanei (Caenorhabditis vulgaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN   [1] {ECO:0000313|Proteomes:UP000008281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG   Caenorhabditis remanei Sequencing Consortium;
RA   Wilson R.K.;
RT   "PCAP assembly of the Caenorhabditis remanei genome.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; DS270573; EFO95669.1; -; Genomic_DNA.
DR   RefSeq; XP_003087924.1; XM_003087876.1.
DR   AlphaFoldDB; E3NUJ8; -.
DR   STRING; 31234.E3NUJ8; -.
DR   EnsemblMetazoa; CRE05360.1; CRE05360.1; WBGene00062672.
DR   eggNOG; KOG2189; Eukaryota.
DR   HOGENOM; CLU_005230_0_0_1; -.
DR   InParanoid; E3NUJ8; -.
DR   OMA; CEMILVK; -.
DR   OrthoDB; 1967517at2759; -.
DR   Proteomes; UP000008281; Unassembled WGS sequence.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF56; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 4; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        446..469
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        616..637
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        649..669
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        681..704
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        738..757
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   REGION          18..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          779..801
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          91..157
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   801 AA;  91768 MW;  F262C814A455BC05 CRC64;
     MSTTTSISEP ILHQSAKINL TPPGKNPISS HQKKMSDKSD EISMFRSEPM KLYQMILVKE
     AAFECVAELG KHGNVQFIDL NAKLSLYSRS FVKQMRRCEE MERKLRFLEK QVITCKPGLD
     PKSIDFGDLS APTQAEMIQL EHKLDQLEKE FLDLNNNDYA LRRNLNSSRE FLHVMKLVDE
     FFQVEMFSKS FGFGGLPSSN ELPMTPLLGA DDNAWFVAGV LPLDKKESFE RVLWRACRRT
     AFVRTSDSHF LVNDPVTLEP LPKCVFIVFF KGESLRLIVE KVCDGFNATQ YPCPKSSKDR
     KMKMSETEGR MNDLTVVIDT TQTHRYTILK DLSYELPIWL KNIQIQKSVF GVMNMFTVDT
     NGFLAGECWI PAAAEENVRQ ALHDGFKASG TEVEPILNEL WTNAPPPTLH KTNKFTRVFQ
     SIVDSYGVGQ YREVNPAPYT IITFPFLFAI MFGDAAHGAI LLLAGLFFIK NERKIEAKKI
     RDEVKNINLF VKLKIMNFQI FNTFYGGRYI MMLMGLFSIY TGFLYNDAFA KSFNVFGSGW
     SNSYNTLGPS NFFHTYSETQ LDWWIARAYR KKREFALELV PEKSFDYEKT YPFGVDPIWN
     IADNRLSFLN SMKMKASVVI GITQMTFGVF LSVLNHIHFK SYIDVITNFI PQVIFLSCIF
     IYLCIQIIVK WIFFNVNAGD ILGYAYPGSH CAPSLLIGLI NMFMFKKRNE GYYDQDGKVY
     RNCHLGYWYP NQRLVETVLI SIAVACIPIM LLGKPLWVRF VTSKRHKLQE TKSLKSIKRN
     GTTVSAPTSP VVETGPPRFV S
//