ID E3QP00_COLGM Unreviewed; 761 AA.
AC E3QP00;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=tyrosinase {ECO:0000256|ARBA:ARBA00011906};
DE EC=1.14.18.1 {ECO:0000256|ARBA:ARBA00011906};
GN ORFNames=GLRG_07602 {ECO:0000313|EMBL:EFQ32588.1};
OS Colletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize
OS anthracnose fungus) (Glomerella graminicola).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum graminicola species complex.
OX NCBI_TaxID=645133 {ECO:0000313|Proteomes:UP000008782};
RN [1] {ECO:0000313|Proteomes:UP000008782}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M1.001 / M2 / FGSC 10212 {ECO:0000313|Proteomes:UP000008782};
RX PubMed=22885923; DOI=10.1038/ng.2372;
RA O'Connell R.J., Thon M.R., Hacquard S., Amyotte S.G., Kleemann J.,
RA Torres M.F., Damm U., Buiate E.A., Epstein L., Alkan N., Altmueller J.,
RA Alvarado-Balderrama L., Bauser C.A., Becker C., Birren B.W., Chen Z.,
RA Choi J., Crouch J.A., Duvick J.P., Farman M.A., Gan P., Heiman D.,
RA Henrissat B., Howard R.J., Kabbage M., Koch C., Kracher B., Kubo Y.,
RA Law A.D., Lebrun M.-H., Lee Y.-H., Miyara I., Moore N., Neumann U.,
RA Nordstroem K., Panaccione D.G., Panstruga R., Place M., Proctor R.H.,
RA Prusky D., Rech G., Reinhardt R., Rollins J.A., Rounsley S., Schardl C.L.,
RA Schwartz D.C., Shenoy N., Shirasu K., Sikhakolli U.R., Stueber K.,
RA Sukno S.A., Sweigard J.A., Takano Y., Takahara H., Trail F.,
RA van der Does H.C., Voll L.M., Will I., Young S., Zeng Q., Zhang J.,
RA Zhou S., Dickman M.B., Schulze-Lefert P., Ver Loren van Themaat E.,
RA Ma L.-J., Vaillancourt L.J.;
RT "Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered
RT by genome and transcriptome analyses.";
RL Nat. Genet. 44:1060-1065(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone; Xref=Rhea:RHEA:34287,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57504,
CC ChEBI:CHEBI:57924; EC=1.14.18.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000426};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-tyrosine + O2 = H2O + L-dopaquinone; Xref=Rhea:RHEA:18117,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57924,
CC ChEBI:CHEBI:58315; EC=1.14.18.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001038};
CC -!- COFACTOR:
CC Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC Evidence={ECO:0000256|ARBA:ARBA00001973};
CC -!- SIMILARITY: Belongs to the tyrosinase family.
CC {ECO:0000256|ARBA:ARBA00009928}.
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DR EMBL; GG697363; EFQ32588.1; -; Genomic_DNA.
DR RefSeq; XP_008096608.1; XM_008098417.1.
DR AlphaFoldDB; E3QP00; -.
DR STRING; 645133.E3QP00; -.
DR EnsemblFungi; EFQ32588; EFQ32588; GLRG_07602.
DR GeneID; 24412967; -.
DR VEuPathDB; FungiDB:GLRG_07602; -.
DR eggNOG; ENOG502R1BY; Eukaryota.
DR HOGENOM; CLU_013691_3_0_1; -.
DR OrthoDB; 1908494at2759; -.
DR Proteomes; UP000008782; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004503; F:tyrosinase activity; IEA:UniProtKB-EC.
DR Gene3D; 2.60.310.20; -; 1.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR041640; Tyrosinase_C.
DR InterPro; IPR002227; Tyrosinase_Cu-bd.
DR PANTHER; PTHR11474:SF76; TYROSINASE; 1.
DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR Pfam; PF18132; Tyosinase_C; 1.
DR Pfam; PF00264; Tyrosinase; 1.
DR PRINTS; PR00092; TYROSINASE.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR PROSITE; PS00497; TYROSINASE_1; 1.
DR PROSITE; PS00498; TYROSINASE_2; 1.
PE 3: Inferred from homology;
KW Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008782}.
FT DOMAIN 103..120
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00497"
FT DOMAIN 325..336
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00498"
SQ SEQUENCE 761 AA; 84778 MW; 2426777D33DA17A9 CRC64;
MSVDVNALKS AQARGLTVGV IPKGVGKPLR LEIDDFLQDV ELANLYFLAL EAFMSKKLSE
SPFSYYEICG IHGQPWRAWD GVKSAEFGFS AGSPDPQSGY CSHGSVIFPT WHRVYVAQFE
QALYLHAAEI APKLKAQAAL DRFRIPYFDP FLPRQKLVTE DIYTYGIPVI FLLPHIQVRR
PESPSSWVSM ANPLYQFKFP ADGKGGFDWS MYTQIPAARD LTIRGLNTAT QSADHSYVMR
AFDNAYNPVS GLSSQTPQSI WHVMFGKQTW VQMSNHYDPR TRDPASVVYN ANSLEGFHDN
IHNQLATGPQ GSSGHMGSPA FAGFDPSFWL HHCNVDRLLA IWQGIHSLDP ESVAWWTSLE
VPEGNFVEPG RLAETPRTPL VPFRKGLTAD SKPIWWTSNE CRNHLDLGYD YPQTAAARKS
GDIVRSLTAW ANTQLGWLAP RSPRPADEGA RAQLKRQINQ PMPFFPLKVL IDGKTPFSNG
QAFIGSMATT MTARISANNK PLSVSRRLLN RAKTVIKVYS PRRRHRKPTE VTAGSGVTIN
RSSDSIATPQ QLSQLVLSTA LPSANMDFNR CYGHLGDLIS HHKMTHWNAT FSVDKFSLDG
SFTIFFFLGD FSPDVESWII DPHLVGSSGI FANSRATITI GACANCAKQE AGGIKYMDTI
ALTPALLTYW DSQEEHYGCR VGDLSPDYVL PFLTRNLHWR IVNSHGAQVP RETITSLKVM
VYSEIVTLPH NITDKPQFEG QNVHYEVTNG RPGGIHTGED M
//
