GenomeNet

Database: UniProt
Entry: E3RQQ3_PYRTT
LinkDB: E3RQQ3_PYRTT
Original site: E3RQQ3_PYRTT 
ID   E3RQQ3_PYRTT            Unreviewed;       490 AA.
AC   E3RQQ3;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   24-JAN-2024, entry version 57.
DE   RecName: Full=Vacuolar calcium ion transporter {ECO:0000256|RuleBase:RU365028};
GN   ORFNames=PTT_11070 {ECO:0000313|EMBL:EFQ91965.1};
OS   Pyrenophora teres f. teres (strain 0-1) (Barley net blotch fungus)
OS   (Drechslera teres f. teres).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae;
OC   Pyrenophora.
OX   NCBI_TaxID=861557 {ECO:0000313|Proteomes:UP000001067};
RN   [1] {ECO:0000313|EMBL:EFQ91965.1, ECO:0000313|Proteomes:UP000001067}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=0-1 {ECO:0000313|EMBL:EFQ91965.1,
RC   ECO:0000313|Proteomes:UP000001067};
RX   PubMed=21067574; DOI=10.1186/gb-2010-11-11-r109;
RA   Ellwood S.R., Liu Z., Syme R.A., Lai Z., Hane J.K., Keiper F., Moffat C.S.,
RA   Oliver R.P., Friesen T.L.;
RT   "A first genome assembly of the barley fungal pathogen Pyrenophora teres f.
RT   teres.";
RL   Genome Biol. 11:R109.1-R109.14(2010).
CC   -!- FUNCTION: Has a role in promoting intracellular calcium ion
CC       sequestration via the exchange of calcium ions for hydrogen ions across
CC       the vacuolar membrane. Involved also in manganese ion homeostasis via
CC       its uptake into the vacuole. {ECO:0000256|RuleBase:RU365028}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Vacuole membrane
CC       {ECO:0000256|RuleBase:RU365028}.
CC   -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC       family. {ECO:0000256|ARBA:ARBA00008170, ECO:0000256|RuleBase:RU365028}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU365028}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GL534524; EFQ91965.1; -; Genomic_DNA.
DR   RefSeq; XP_003299958.1; XM_003299910.1.
DR   AlphaFoldDB; E3RQQ3; -.
DR   EnsemblFungi; EFQ91965; EFQ91965; PTT_11070.
DR   KEGG; pte:PTT_11070; -.
DR   eggNOG; KOG1397; Eukaryota.
DR   HOGENOM; CLU_008721_1_1_1; -.
DR   OrthoDB; 276371at2759; -.
DR   Proteomes; UP000001067; Unassembled WGS sequence.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015369; F:calcium:proton antiporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR   InterPro; IPR004713; CaH_exchang.
DR   InterPro; IPR004798; CAX-like.
DR   InterPro; IPR004837; NaCa_Exmemb.
DR   InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR   NCBIfam; TIGR00378; cax; 1.
DR   PANTHER; PTHR31503; VACUOLAR CALCIUM ION TRANSPORTER; 1.
DR   PANTHER; PTHR31503:SF14; VACUOLAR CALCIUM ION TRANSPORTER; 1.
DR   Pfam; PF01699; Na_Ca_ex; 2.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|RuleBase:RU365028};
KW   Calcium {ECO:0000256|RuleBase:RU365028};
KW   Calcium transport {ECO:0000256|RuleBase:RU365028};
KW   Ion transport {ECO:0000256|RuleBase:RU365028};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365028};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001067};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU365028};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU365028}; Transport {ECO:0000256|RuleBase:RU365028};
KW   Vacuole {ECO:0000256|RuleBase:RU365028}.
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   TRANSMEM        152..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   TRANSMEM        185..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   TRANSMEM        228..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   TRANSMEM        266..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   TRANSMEM        321..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   TRANSMEM        390..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   TRANSMEM        418..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   TRANSMEM        446..466
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   DOMAIN          120..287
FT                   /note="Sodium/calcium exchanger membrane region"
FT                   /evidence="ECO:0000259|Pfam:PF01699"
FT   DOMAIN          322..462
FT                   /note="Sodium/calcium exchanger membrane region"
FT                   /evidence="ECO:0000259|Pfam:PF01699"
FT   REGION          1..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..49
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   490 AA;  53416 MW;  17BAC5066D2C62FD CRC64;
     MAHHGRSSRD YPAGRSSHHR SSRDREYVSE KTPRTVPPHS DDRRSRSRRR SSLPQYNHNG
     HAVTPGIHPE GESGRRGFHP IKFLAICGRS SSMPSMLVNL LWPIVPVAIA MHFAKREWHL
     PIFICNYIAM LPAANMLGFA GQEFSRKMPN KAFAVVLETT FGSIVEIILF MTLLKTSNGD
     SNVQVIRAAI LGSILANLLL CLGICFIAGG LKNKTQDFHS AISENGSGLM LVASMALVLP
     AIFYSYLNGN ADFQQTINVA TNTRLISRGV AIISIVGFFI YLAFQTMSHD GLLHEIYEAD
     DHKDKDRHEE LKKPKLTLTE VIIALIISVT CVALVAIALV QEIPHLVEER GISDAFIGLI
     LIPLVEKIAE HLLAIDEAYD NQINMALAHV LGASIQTALF NAPLVVLVGW GIGVHMDYNF
     TMFDAAALVL AVLAVGSFLR DGSSNYLEGV LCVMIYMIIA ICAFYFPNPL HEGASTAGHS
     AGAAEGGGGH
//
DBGET integrated database retrieval system